HK1153511A1 - Method of identifying alzheimers disease risk factors - Google Patents
Method of identifying alzheimers disease risk factorsInfo
- Publication number
- HK1153511A1 HK1153511A1 HK11107605.9A HK11107605A HK1153511A1 HK 1153511 A1 HK1153511 A1 HK 1153511A1 HK 11107605 A HK11107605 A HK 11107605A HK 1153511 A1 HK1153511 A1 HK 1153511A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- identifying
- risk factors
- disease risk
- alzheimers disease
- alzheimers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8820308P | 2008-08-12 | 2008-08-12 | |
US18667309P | 2009-06-12 | 2009-06-12 | |
US22464709P | 2009-07-10 | 2009-07-10 | |
PCT/US2009/053373 WO2010019550A2 (en) | 2008-08-12 | 2009-08-11 | Method of identifying disease risk factors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1153511A1 true HK1153511A1 (en) | 2012-03-30 |
Family
ID=41669605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11107605.9A HK1153511A1 (en) | 2008-08-12 | 2011-07-21 | Method of identifying alzheimers disease risk factors |
Country Status (32)
Country | Link |
---|---|
US (4) | US8815508B2 (pt) |
EP (2) | EP2324126B1 (pt) |
JP (4) | JP5833922B2 (pt) |
KR (3) | KR20160127181A (pt) |
CN (3) | CN102177436B (pt) |
AU (3) | AU2009282114B2 (pt) |
BR (1) | BRPI0917948A2 (pt) |
CA (1) | CA2735578C (pt) |
CL (1) | CL2011000298A1 (pt) |
CO (1) | CO6351823A2 (pt) |
CY (1) | CY1115412T1 (pt) |
DK (1) | DK2324126T3 (pt) |
DO (1) | DOP2011000052A (pt) |
EA (1) | EA021399B1 (pt) |
ES (1) | ES2463766T3 (pt) |
GE (1) | GEP20146107B (pt) |
HK (1) | HK1153511A1 (pt) |
HR (1) | HRP20140709T1 (pt) |
IL (2) | IL211140A (pt) |
MA (1) | MA32619B1 (pt) |
ME (1) | ME01898B (pt) |
MX (1) | MX2011001671A (pt) |
NZ (3) | NZ619895A (pt) |
PE (3) | PE20150362A1 (pt) |
PL (1) | PL2324126T3 (pt) |
PT (1) | PT2324126E (pt) |
RS (1) | RS53383B (pt) |
SG (1) | SG193793A1 (pt) |
SI (1) | SI2324126T1 (pt) |
SM (1) | SMT201400088B (pt) |
WO (1) | WO2010019550A2 (pt) |
ZA (1) | ZA201101095B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ619895A (en) * | 2008-08-12 | 2015-12-24 | Zinfandel Pharmaceuticals Inc | Method of identifying disease risk factors |
US8846315B2 (en) * | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
US9646134B2 (en) * | 2010-05-25 | 2017-05-09 | The Regents Of The University Of California | Bambam: parallel comparative analysis of high-throughput sequencing data |
KR101952965B1 (ko) | 2010-05-25 | 2019-02-27 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Bambam:고처리율 서열분석 데이터의 병렬 비교 분석 |
AU2013204020B2 (en) * | 2011-01-10 | 2016-03-31 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
EA201691399A1 (ru) | 2011-01-10 | 2016-10-31 | Зинфандел Фармасьютикалз, Инк. | Способы и готовые лекарственные формы для лечения болезни альцгеймера |
MX358594B (es) * | 2011-01-10 | 2018-08-27 | Zinfandel Pharmaceuticals Inc | Factores de riesgo de enfermedad y métodos de uso. |
US20120231457A1 (en) * | 2011-03-10 | 2012-09-13 | Nikolaos Tezapsidis | Compositions and methods for assessing a genetic risk of developing late-onset alzheimer's disease (load) |
US8718950B2 (en) | 2011-07-08 | 2014-05-06 | The Medical College Of Wisconsin, Inc. | Methods and apparatus for identification of disease associated mutations |
US20130080182A1 (en) * | 2011-09-26 | 2013-03-28 | Athleticode Inc. | Methods For Using DNA Testing To Screen For Genotypes Relevant To Athleticism, Health And Risk Of Injury |
JP2015505314A (ja) * | 2012-01-09 | 2015-02-19 | 武田薬品工業株式会社 | アルツハイマー病を治療する方法及び医薬品 |
GB201209689D0 (en) * | 2012-05-31 | 2012-07-18 | Imp Innovations Ltd | Methods |
WO2014134615A1 (en) * | 2013-03-01 | 2014-09-04 | Actx, Inc. | Cloud-like medical-information service |
JPWO2015174544A1 (ja) * | 2014-05-16 | 2017-04-20 | 国立研究開発法人国立精神・神経医療研究センター | 精神疾患判定マーカー |
US11214829B2 (en) | 2015-07-23 | 2022-01-04 | Asuragen, Inc. | Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments |
CN109476698B (zh) * | 2016-05-20 | 2023-10-17 | 西达-赛奈医疗中心 | 基于基因的炎性肠病诊断 |
CN105969885A (zh) * | 2016-06-24 | 2016-09-28 | 江苏雄鸣医药科技有限公司 | 一种阿尔兹海默症的基因诊断试剂盒 |
US11352625B2 (en) | 2017-01-12 | 2022-06-07 | Duke University | Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease |
AU2018239433B2 (en) | 2017-03-21 | 2024-02-01 | Indiana University Research And Technology Corporation | A genetically modified mouse expressing human APOE4p and mouse Trem2 p.R47H and methods of use thereof |
WO2019028080A1 (en) * | 2017-07-31 | 2019-02-07 | Quest Diagnostics Investments Llc | DETECTION OF THE ISOTYPE OF APOLIPOPROTEIN E BY MASS SPECTROMETRY |
JP2021501415A (ja) * | 2017-10-31 | 2021-01-14 | ジーイー・ヘルスケア・リミテッド | 認知症の病理学および/または転帰を診断するための医療システム |
WO2019152675A2 (en) * | 2018-01-31 | 2019-08-08 | Curelator, Inc. | Early feedback of disease factors to improve patient quality of life, engagement and persistence |
KR102303638B1 (ko) * | 2018-04-13 | 2021-09-23 | 사회복지법인 삼성생명공익재단 | 알츠하이머성 치매가 발병될 가능성 평가방법 |
US20210230696A1 (en) | 2018-05-07 | 2021-07-29 | Biotx.Ai Gmbh | Method for predicting the risk of late-onset alzheimer's diseases |
EP3626835A1 (en) * | 2018-09-18 | 2020-03-25 | Sistemas Genómicos, S.L. | Method for genotypically identifying both alleles of at least one locus of a subject's hla gene |
KR102127903B1 (ko) * | 2019-01-29 | 2020-06-29 | 연세대학교 산학협력단 | 염증성 호흡기 질환의 진단용 바이오마커 |
CN114514329A (zh) * | 2019-05-30 | 2022-05-17 | 纽卡斯尔大学 | 治疗或预防方法 |
CN111187825A (zh) * | 2020-01-15 | 2020-05-22 | 丁玎 | 阿尔兹海默症的tomm40基因及apoe基因的易感位点的检测方法及试剂盒 |
CN111593107A (zh) * | 2020-01-15 | 2020-08-28 | 丁玎 | 阿尔兹海默症易感位点rs10119与rs71352238的检测方法及试剂盒 |
KR102535235B1 (ko) * | 2020-11-25 | 2023-05-26 | 서울대학교산학협력단 | 알츠하이머병 발병 위험도 예측을 위한 단일염기다형성 마커 및 이의 용도 |
RU2757522C1 (ru) * | 2021-06-02 | 2021-10-18 | Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) | СПОСОБ ПРОГНОЗИРОВАНИЯ РАЗВИТИЯ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 1 и 2 ТИПА (варианты) |
KR20230150497A (ko) * | 2022-04-22 | 2023-10-31 | 사회복지법인 삼성생명공익재단 | 유럽-동아시아인 데이터 기반 알츠하이머병 치매의 발병 위험군 또는 조기 증상 발현 위험군, 기억상실형 경도인지장애의 발병 위험군 및/또는 아밀로이드β 침착에 대한 PET 양성 위험군을 예측하기 위한 정보를 제공하는 방법 |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US663780A (en) * | 1898-09-09 | 1900-12-11 | Wheeler & Wilson Mfg Co | Trimming attachment for sewing-machines. |
US4302204A (en) | 1979-07-02 | 1981-11-24 | The Board Of Trustees Of Leland Stanford Junior University | Transfer and detection of nucleic acids |
US4358535A (en) | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
FI63596C (fi) | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
US6060237A (en) * | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US5112460A (en) * | 1986-10-21 | 1992-05-12 | Northeastern University | High performance microcapillary gel electrophoresis |
EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
US5595883A (en) * | 1990-06-01 | 1997-01-21 | E. R. Squibb & Sons, Inc. | Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid |
US5171750A (en) * | 1991-09-26 | 1992-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted phenserines as specific inhibitors of acetylcholinesterase |
TW263504B (pt) | 1991-10-03 | 1995-11-21 | Pfizer | |
US5326770A (en) * | 1992-07-17 | 1994-07-05 | The Du Pont Merck Pharmaceutical Company | Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals |
NZ248573A (en) * | 1992-09-10 | 1996-02-27 | Lilly Co Eli | 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions |
ES2148116T1 (es) * | 1992-10-13 | 2000-10-16 | Univ Duke | Metodos de detectar la enfermedad de alzheimer. |
TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
ES2100129B1 (es) | 1995-10-11 | 1998-02-16 | Medichem Sa | Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. |
JPH09176162A (ja) | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
US6128587A (en) | 1997-01-14 | 2000-10-03 | The Regents Of The University Of California | Method and apparatus using Bayesian subfamily identification for sequence analysis |
US5904824A (en) * | 1997-03-07 | 1999-05-18 | Beckman Instruments, Inc. | Microfluidic electrophoresis device |
WO1998039967A1 (en) * | 1997-03-12 | 1998-09-17 | The General Hospital Corporation | A method for treating or preventing alzheimer's disease |
ATE229004T1 (de) * | 1997-03-31 | 2002-12-15 | Korea Res Inst Chem Tech | Chinolinische sulfid-derivate als nmda rezeptor- antagonisten und verfahren zu ihrer herstellung |
EP1047423B1 (en) * | 1997-11-19 | 2006-05-10 | Takeda Pharmaceutical Company Limited | Novel apoptosis inhibitors |
US6964868B1 (en) | 1998-01-28 | 2005-11-15 | Nuvelo, Inc. | Human genes and gene expression products II |
US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
WO1999058675A2 (en) | 1998-05-14 | 1999-11-18 | Chiron Corporation | Human genes and gene expression products v |
WO1999066072A2 (en) | 1998-06-16 | 1999-12-23 | Nova Molecular, Inc. | Methods for treating a neurological disease by determining bche genotype |
AU773765B2 (en) | 1998-10-01 | 2004-06-03 | Variagenics, Inc. | Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of variant GPIIIA and/or variant GPIIB allele |
AU771187B2 (en) | 1998-11-10 | 2004-03-18 | Genset | Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait |
US6191154B1 (en) * | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
CN1078616C (zh) * | 1998-12-16 | 2002-01-30 | 中国科学院上海生命科学研究中心 | 一种检测样品中是否存在老年痴呆病基因的方法和试剂盒 |
JP2000273040A (ja) * | 1999-01-19 | 2000-10-03 | Sankyo Co Ltd | トログリタゾンを含有するアポトーシス抑制剤 |
US6401043B1 (en) | 1999-04-26 | 2002-06-04 | Variagenics, Inc. | Variance scanning method for identifying gene sequence variances |
EP1210087A2 (en) | 1999-04-29 | 2002-06-05 | City of Hope | Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (age's) |
US6573049B1 (en) | 1999-07-26 | 2003-06-03 | Nuvelo, Inc. | Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease |
DE19936719A1 (de) * | 1999-08-06 | 2001-02-15 | Gruenenthal Gmbh | Substituierte 1,5-Dihydropyrrol-2-on-Derivate |
US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US6532467B1 (en) | 2000-04-10 | 2003-03-11 | Sas Institute Inc. | Method for selecting node variables in a binary decision tree structure |
US6432985B2 (en) | 2000-04-25 | 2002-08-13 | Hoffmann-La Roche Inc. | Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists |
EP1326822A2 (en) * | 2000-10-11 | 2003-07-16 | Esperion Therapeutics Inc. | Ketone compounds and compositions for cholesterol management and related uses |
AU2002211667A1 (en) * | 2000-10-11 | 2002-04-22 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
WO2002030884A2 (en) | 2000-10-11 | 2002-04-18 | Esperion Therapeutics, Inc. | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
US20040122091A1 (en) | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
EP1341543A4 (en) | 2000-11-24 | 2009-09-02 | Vascular Biogenics Ltd | METHODS INVOLVING DEFINED OXIDE PHOSPHOLIPIDS, AND COMPOSITIONS CONTAINING THE SAME, FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US6495335B2 (en) | 2000-12-07 | 2002-12-17 | Mario Chojkier | Compositions and methods for diagnosing alzheimer's disease |
DE10132725A1 (de) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituierte γ-Lactonverbindungen |
US6680299B2 (en) * | 2001-07-27 | 2004-01-20 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
US20040204502A1 (en) * | 2001-10-11 | 2004-10-14 | Dasseux Jean-Louis Henri | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
US20050020694A1 (en) | 2001-10-11 | 2005-01-27 | Dasseux Jean-Louis Henri | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
US6828462B2 (en) | 2001-11-07 | 2004-12-07 | Merz Pharma Gmbh & Co. Kgaa | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
US7132244B2 (en) | 2001-11-21 | 2006-11-07 | Syn X Pharma, Inc. | Betaine/GABA transport protein biopolymer marker indicative of insulin resistance |
US7052849B2 (en) | 2001-11-23 | 2006-05-30 | Syn X Pharma, Inc. | Protein biopolymer markers predictive of insulin resistance |
US7135297B2 (en) | 2001-11-23 | 2006-11-14 | Nanogen Inc. | Protein biopolymer markers indicative of insulin resistance |
US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
WO2004005510A1 (ja) | 2002-07-05 | 2004-01-15 | Shionogi & Co., Ltd. | 新規Nogo受容体様ポリペプチドおよびそのDNA |
US20040265849A1 (en) * | 2002-11-22 | 2004-12-30 | Applera Corporation | Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof |
CN1753662A (zh) * | 2002-12-24 | 2006-03-29 | 神经化学(国际)有限公司 | 用于治疗β-淀粉状蛋白相关疾病的治疗制剂 |
CA2515783A1 (en) * | 2003-02-14 | 2004-09-02 | Intergenetics Incorporated | Statistically identifying an increased risk for disease |
US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
US20050004179A1 (en) * | 2003-05-22 | 2005-01-06 | Pedersen Ward A. | Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease |
WO2005003766A2 (en) | 2003-06-13 | 2005-01-13 | Whitehead Institute For Biomedical Research | Methods of regulating metabolism and mitochondrial function |
US8084645B2 (en) | 2003-09-19 | 2011-12-27 | Chugai Seiyaku Kabushiki Kaisha | 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors |
US20050277129A1 (en) | 2004-01-22 | 2005-12-15 | Genaissance Pharmaceuticals | APOE genetic markers associated with age of onset of Alzheimer's disease |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
WO2006054297A2 (en) | 2004-11-17 | 2006-05-26 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
EP1859056A2 (en) * | 2005-01-31 | 2007-11-28 | Perlegen Sciences, Inc. | Genetic basis of alzheimer's disease and diagnosis and treatment thereof |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
JP2009508959A (ja) * | 2005-09-22 | 2009-03-05 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | 認識機能の改善のためのロシグリタゾンおよびドネペジルの組合せ |
US7608412B2 (en) | 2005-10-05 | 2009-10-27 | Auburn University | P62 as a diagnostic tool for alzheimer's disease |
ES2397944T3 (es) | 2006-03-16 | 2013-03-12 | Metabolic Solutions Development Company Llc | Análogos de tiazolidindiona |
US20080045582A1 (en) | 2006-05-15 | 2008-02-21 | Issam Zineh | ENA-78 Gene Polymorphisms and Protein Concentrations as Diagnostic and Prognostic Tools |
WO2008019187A2 (en) | 2006-05-30 | 2008-02-14 | Mayo Foundation For Medical Education And Research | Detecting and treating dementia |
US7651840B2 (en) * | 2006-07-14 | 2010-01-26 | Celera Corporation | Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof |
AU2007299920A1 (en) | 2006-09-19 | 2008-03-27 | Braincells, Inc. | PPAR Mediated Modulation of Neurogenesis |
US20090042849A1 (en) | 2006-12-06 | 2009-02-12 | Yochai Birnbaum | Phosphorylation of 5-lipoxygenase at ser523 and uses thereof |
US7794937B2 (en) | 2006-12-22 | 2010-09-14 | Quest Diagnostics Investments Incorporated | Cystic fibrosis transmembrane conductance regulator gene mutations |
GB0702537D0 (en) | 2007-02-12 | 2007-03-21 | Leuven K U Res & Dev | Treatment for excessive adiposity |
US20080286876A1 (en) | 2007-05-14 | 2008-11-20 | Chissoe Stephanie | GENES ASSOCIATED WITH ALZHEIMER'S DISEASE - Hltdip |
US8652508B2 (en) | 2007-05-25 | 2014-02-18 | Children's Medical Center Corporation | Dietary formulations and methods for treatment of inflammation and other disorders |
TW200914006A (en) | 2007-07-12 | 2009-04-01 | Takeda Pharmaceutical | Coated preparation |
US8846315B2 (en) * | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
NZ619895A (en) * | 2008-08-12 | 2015-12-24 | Zinfandel Pharmaceuticals Inc | Method of identifying disease risk factors |
US20100092470A1 (en) | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
US20100136584A1 (en) | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
CN102308004A (zh) | 2008-10-30 | 2012-01-04 | 卡里斯生命科学卢森堡控股有限责任公司 | 评价rna图案的方法 |
CN107254538A (zh) | 2008-11-12 | 2017-10-17 | 卡里斯生命科学瑞士控股有限责任公司 | 使用外来体来确定表现型的方法和*** |
BRPI0922650A2 (pt) | 2008-12-12 | 2017-07-11 | Poxel | Composto, composição farmacêutica, uso de pelo menos um composto, métodos para tratar doenças, para diagnosticar nefropatia diabética, e para triar compostos, e, uso de sinaptopodina |
JP2012516842A (ja) | 2009-02-02 | 2012-07-26 | ライラ ニュートラシューティカルズ | 代謝症候群の抑制のためのスファランサス・インディクスおよびガルシニア・マンゴスターナ由来の組成物 |
JP5882196B2 (ja) | 2009-04-23 | 2016-03-09 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. | アディポネクチン受容体フラグメントの単量体及び二量体形態ならびに使用の方法 |
CA2709621A1 (en) | 2009-09-11 | 2011-03-11 | Electrophoretics Limited | Markers and methods relating to the assessment of alzheimer's disease |
US20110192239A1 (en) | 2010-02-10 | 2011-08-11 | Selinfreund Richard H | Devices for collection and stabilization of biomarkers in liquid samples |
US9128101B2 (en) | 2010-03-01 | 2015-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
JP2013526852A (ja) | 2010-04-06 | 2013-06-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | 疾患に対する循環バイオマーカー |
EA201691399A1 (ru) * | 2011-01-10 | 2016-10-31 | Зинфандел Фармасьютикалз, Инк. | Способы и готовые лекарственные формы для лечения болезни альцгеймера |
-
2009
- 2009-08-11 NZ NZ619895A patent/NZ619895A/en not_active IP Right Cessation
- 2009-08-11 PE PE2015000030A patent/PE20150362A1/es not_active Application Discontinuation
- 2009-08-11 GE GEAP200912125A patent/GEP20146107B/en unknown
- 2009-08-11 PE PE2015002280A patent/PE20151924A1/es unknown
- 2009-08-11 WO PCT/US2009/053373 patent/WO2010019550A2/en active Application Filing
- 2009-08-11 EA EA201170332A patent/EA021399B1/ru not_active IP Right Cessation
- 2009-08-11 CA CA2735578A patent/CA2735578C/en not_active Expired - Fee Related
- 2009-08-11 ME MEP-2014-70A patent/ME01898B/me unknown
- 2009-08-11 SG SG2013061254A patent/SG193793A1/en unknown
- 2009-08-11 BR BRPI0917948A patent/BRPI0917948A2/pt not_active Application Discontinuation
- 2009-08-11 EP EP09807152.5A patent/EP2324126B1/en active Active
- 2009-08-11 US US13/058,724 patent/US8815508B2/en active Active
- 2009-08-11 KR KR1020167030021A patent/KR20160127181A/ko active Search and Examination
- 2009-08-11 RS RS20140335A patent/RS53383B/en unknown
- 2009-08-11 KR KR1020117005712A patent/KR101729340B1/ko active IP Right Grant
- 2009-08-11 KR KR1020187013536A patent/KR20180053432A/ko not_active Application Discontinuation
- 2009-08-11 MX MX2011001671A patent/MX2011001671A/es active IP Right Grant
- 2009-08-11 CN CN200980140279.0A patent/CN102177436B/zh not_active Expired - Fee Related
- 2009-08-11 PE PE2011000157A patent/PE20110565A1/es not_active Application Discontinuation
- 2009-08-11 DK DK09807152.5T patent/DK2324126T3/da active
- 2009-08-11 CN CN201510173806.5A patent/CN104805198B/zh not_active Expired - Fee Related
- 2009-08-11 NZ NZ591107A patent/NZ591107A/xx not_active IP Right Cessation
- 2009-08-11 PT PT98071525T patent/PT2324126E/pt unknown
- 2009-08-11 PL PL09807152T patent/PL2324126T3/pl unknown
- 2009-08-11 JP JP2011523086A patent/JP5833922B2/ja active Active
- 2009-08-11 AU AU2009282114A patent/AU2009282114B2/en not_active Ceased
- 2009-08-11 CN CN201510007052.6A patent/CN104611421B/zh not_active Expired - Fee Related
- 2009-08-11 EP EP14165474.9A patent/EP2789695B1/en active Active
- 2009-08-11 SI SI200930940T patent/SI2324126T1/sl unknown
- 2009-08-11 ES ES09807152.5T patent/ES2463766T3/es active Active
- 2009-08-11 NZ NZ710443A patent/NZ710443A/en not_active IP Right Cessation
-
2011
- 2011-02-09 IL IL211140A patent/IL211140A/en active IP Right Grant
- 2011-02-10 ZA ZA2011/01095A patent/ZA201101095B/en unknown
- 2011-02-11 DO DO2011000052A patent/DOP2011000052A/es unknown
- 2011-02-11 CL CL2011000298A patent/CL2011000298A1/es unknown
- 2011-03-07 MA MA33680A patent/MA32619B1/fr unknown
- 2011-03-09 CO CO11028662A patent/CO6351823A2/es not_active Application Discontinuation
- 2011-07-21 HK HK11107605.9A patent/HK1153511A1/xx not_active IP Right Cessation
-
2014
- 2014-07-09 SM SM201400088T patent/SMT201400088B/xx unknown
- 2014-07-16 US US14/332,867 patent/US20150073025A1/en not_active Abandoned
- 2014-07-22 HR HRP20140709AT patent/HRP20140709T1/hr unknown
- 2014-07-22 CY CY20141100549T patent/CY1115412T1/el unknown
-
2015
- 2015-06-08 IL IL239277A patent/IL239277A0/en unknown
- 2015-10-29 JP JP2015212976A patent/JP2016047058A/ja active Pending
-
2016
- 2016-07-06 AU AU2016204678A patent/AU2016204678B2/en not_active Ceased
-
2017
- 2017-11-10 JP JP2017217336A patent/JP2018075005A/ja active Pending
-
2018
- 2018-04-04 AU AU2018202373A patent/AU2018202373A1/en not_active Abandoned
- 2018-06-28 US US16/021,261 patent/US10865449B2/en active Active
- 2018-12-05 JP JP2018228465A patent/JP6815372B2/ja active Active
-
2020
- 2020-11-13 US US17/097,705 patent/US20210095345A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1153511A1 (en) | Method of identifying alzheimers disease risk factors | |
IL209587A0 (en) | Method and apparatrus for identifying dietary choices | |
GB0810051D0 (en) | Method of diagnosis | |
EP2358912A4 (en) | METHODS OF ASSESSING RNA PATTERNS | |
GB0906698D0 (en) | Method for quantifying modified peptides | |
EP2365747A4 (en) | METHODS OF TREATING GASTROINTESTINAL DISEASES | |
EP2393416A4 (en) | METHOD AND DEVICE FOR THE QUANTITATIVE DETERMINATION OF THE PROBABILITY OF A DISEASE | |
HK1132550A1 (en) | Method of determining risk of scoliosis | |
EP2341936A4 (en) | METHOD FOR TREATING OR PREVENTING IL-1ß-CONTAINED ILLNESSES | |
EP2136211A4 (en) | PROCEDURE FOR ALLERGIC DISEASE | |
GB201302929D0 (en) | A method of treating alzheimers disease | |
EP2455751A4 (en) | METHOD FOR QUANTIFYING PROTEIN | |
HUP1000432A2 (en) | Method for making shoes | |
GB2470543B (en) | Identification method | |
EG26381A (en) | Method for the identification of oxidizing bacteria for propane | |
PL386031A1 (pl) | Sposób identyfikacji odmian miodu | |
EP2208986A4 (en) | METHOD FOR DETERMINING SELF-INDUCER 2 | |
EP2287604A4 (en) | METHOD FOR THE STUDY OF MORBUS ALZHEIMER | |
EP2438194A4 (en) | METHODS OF SCREENING AND IDENTIFYING COMPOUNDS | |
ZA201008471B (en) | Biomarker for selecting patients and related methods | |
EP2514834A4 (en) | METHOD FOR RNA ANALYSIS | |
EP2290064A4 (en) | PROOF OF PROBLEMS FOR PROLIFERATIVE DISEASES | |
EP2252701A4 (en) | METHOD FOR IDENTIFYING AN ORGANISM | |
IL190526A0 (en) | Method for identifying patients | |
GB0903496D0 (en) | Methods for identification |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20190814 |