HK1129671A1 - Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile - Google Patents

Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Info

Publication number
HK1129671A1
HK1129671A1 HK09108307.2A HK09108307A HK1129671A1 HK 1129671 A1 HK1129671 A1 HK 1129671A1 HK 09108307 A HK09108307 A HK 09108307A HK 1129671 A1 HK1129671 A1 HK 1129671A1
Authority
HK
Hong Kong
Prior art keywords
amino
cyanoethenyl
benzonitrile
dimethylphenyl
pyrimidinyl
Prior art date
Application number
HK09108307.2A
Other languages
English (en)
Inventor
Jerome Emile Georges Guillemont
Didier Philippe Robert Schils
Joannes Josephus Maria Willems
Bart Petrus Anna Maria Jozef Medaer
Elisabeth Therese Jeanne Pasquier
Paul Adriaan Jan Janssen
Jan Heeres
Ruben Gerardus George Leenders
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31725448&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1129671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1129671A1 publication Critical patent/HK1129671A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
HK09108307.2A 2002-08-09 2006-02-09 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile HK1129671A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02078306 2002-08-09
HK06101734.3A HK1081527A1 (en) 2002-08-09 2006-02-09 Processes for the preparation of 4-[4-[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Publications (1)

Publication Number Publication Date
HK1129671A1 true HK1129671A1 (en) 2009-12-04

Family

ID=31725448

Family Applications (4)

Application Number Title Priority Date Filing Date
HK06101734.3A HK1081527A1 (en) 2002-08-09 2006-02-09 Processes for the preparation of 4-[4-[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
HK09108307.2A HK1129671A1 (en) 2002-08-09 2006-02-09 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
HK12101815.7A HK1161869A1 (en) 2002-08-09 2012-02-23 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
HK13102335.5A HK1174922A1 (en) 2002-08-09 2013-02-25 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 4-[[4-[[4-(2-)-2,6-]]-2-]]

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK06101734.3A HK1081527A1 (en) 2002-08-09 2006-02-09 Processes for the preparation of 4-[4-[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK12101815.7A HK1161869A1 (en) 2002-08-09 2012-02-23 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
HK13102335.5A HK1174922A1 (en) 2002-08-09 2013-02-25 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6- dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 4-[[4-[[4-(2-)-2,6-]]-2-]]

Country Status (27)

Country Link
US (3) US7399856B2 (ko)
EP (1) EP1529032B1 (ko)
JP (1) JP4822707B2 (ko)
KR (2) KR101140785B1 (ko)
CN (4) CN102225902B (ko)
AR (1) AR040964A1 (ko)
AU (1) AU2003266413B2 (ko)
BR (1) BR0313545B1 (ko)
CA (2) CA2493794C (ko)
CL (1) CL2010000284A1 (ko)
CY (1) CY1114428T1 (ko)
DK (1) DK1529032T3 (ko)
EA (1) EA007953B1 (ko)
ES (1) ES2422196T3 (ko)
HK (4) HK1081527A1 (ko)
HR (1) HRP20050104B1 (ko)
IL (1) IL166710A (ko)
IS (1) IS2980B (ko)
MX (1) MXPA05001541A (ko)
MY (1) MY144894A (ko)
NO (1) NO330013B1 (ko)
NZ (1) NZ538611A (ko)
PL (1) PL208533B1 (ko)
PT (1) PT1529032E (ko)
SI (1) SI1529032T1 (ko)
TW (1) TWI314146B (ko)
WO (1) WO2004016581A1 (ko)

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CA2577288C (en) * 2004-09-02 2010-11-30 Janssen Pharmaceutica N.V. Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
CA2577273C (en) * 2004-09-02 2013-11-19 Janssen Pharmaceutica N.V. Fumarate of 4-((4-((4-(2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile
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WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
KR101879468B1 (ko) * 2011-04-15 2018-07-17 엠큐어 파마슈티컬즈 리미티드 릴피비린 중간체의 제조를 위한 공정
EP2702044B1 (en) 2011-04-25 2017-03-22 Hetero Research Foundation Process for rilpivirine
EP2755959B1 (en) * 2011-09-16 2018-05-16 Hetero Research Foundation Rilpivirine hydrochloride
WO2013170421A1 (zh) * 2012-05-14 2013-11-21 上海迪赛诺药业有限公司 利匹韦林盐酸盐醇化物多晶型物及其制备方法
WO2013179105A1 (en) * 2012-06-01 2013-12-05 Laurus Labs Private Limited Improved process for preparation of rilpivirine and pharmaceutically acceptable salts thereof
EP2872492B1 (en) * 2012-07-12 2018-01-31 Hetero Research Foundation Process for the preparation of rilpivirine using a novel intermediate
CZ201532A3 (cs) 2015-01-21 2015-02-25 Zentiva, K.S. Způsob výroby vysoce čistého Rilpivirinu a jeho solí
CN106008366A (zh) * 2016-05-25 2016-10-12 山东大学 一种利匹韦林的制备方法
SI3528791T1 (sl) 2016-10-24 2024-04-30 Janssen Sciences Ireland Unlimited Company Disperzibilne sestave
WO2020084142A1 (en) 2018-10-25 2020-04-30 Minakem Process for the preparation of rilpivirine
CN110526873B (zh) * 2019-08-15 2022-09-16 复旦大学 氰乙烯基取代的苯并二芳基嘧啶类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
US7705148B2 (en) 2010-04-27
US20060167253A1 (en) 2006-07-27
PL373679A1 (en) 2005-09-05
MXPA05001541A (es) 2005-04-19
CN1681774A (zh) 2005-10-12
CN101481356B (zh) 2012-07-11
CL2010000284A1 (es) 2010-08-20
ES2422196T3 (es) 2013-09-09
KR20050040906A (ko) 2005-05-03
TWI314146B (en) 2009-09-01
AR040964A1 (es) 2005-04-27
SI1529032T1 (sl) 2013-08-30
TW200418810A (en) 2004-10-01
HK1174922A1 (en) 2013-06-21
KR101140785B1 (ko) 2012-05-03
HRP20050104A2 (en) 2006-03-31
PL208533B1 (pl) 2011-05-31
PT1529032E (pt) 2013-07-11
CN101481356A (zh) 2009-07-15
US20080167464A1 (en) 2008-07-10
CN102702111A (zh) 2012-10-03
HK1161869A1 (en) 2012-08-10
NO20050524L (no) 2005-02-01
HK1081527A1 (en) 2006-05-19
EA007953B1 (ru) 2007-02-27
NO330013B1 (no) 2011-02-07
IS2980B (is) 2017-09-15
US7399856B2 (en) 2008-07-15
KR101086678B1 (ko) 2011-11-25
CA2493794A1 (en) 2004-02-26
CN102225902B (zh) 2013-04-24
BR0313545B1 (pt) 2021-07-27
EP1529032A1 (en) 2005-05-11
HRP20050104B1 (hr) 2014-02-14
JP4822707B2 (ja) 2011-11-24
CA2493794C (en) 2010-05-25
CN102702111B (zh) 2014-12-17
IL166710A (en) 2010-12-30
MY144894A (en) 2011-11-30
DK1529032T3 (da) 2013-07-08
CN102225902A (zh) 2011-10-26
EA200500325A1 (ru) 2005-06-30
IL166710A0 (en) 2006-01-15
WO2004016581A1 (en) 2004-02-26
JP2005537303A (ja) 2005-12-08
CN100554245C (zh) 2009-10-28
BR0313545A (pt) 2005-07-12
CA2686429C (en) 2010-11-16
EP1529032B1 (en) 2013-04-24
US20070191407A1 (en) 2007-08-16
US7563922B2 (en) 2009-07-21
CY1114428T1 (el) 2016-08-31
AU2003266413B2 (en) 2009-04-02
IS7621A (is) 2004-12-29
KR20100127889A (ko) 2010-12-06
NZ538611A (en) 2007-03-30
AU2003266413A1 (en) 2004-03-03
CA2686429A1 (en) 2004-02-26

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