HK1128285A1 - Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase - Google Patents
Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylaseInfo
- Publication number
- HK1128285A1 HK1128285A1 HK09105787.7A HK09105787A HK1128285A1 HK 1128285 A1 HK1128285 A1 HK 1128285A1 HK 09105787 A HK09105787 A HK 09105787A HK 1128285 A1 HK1128285 A1 HK 1128285A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- derivatives
- amino
- alkyl
- histone deacetylase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100576 | 2006-01-19 | ||
| PCT/EP2007/050381 WO2007082882A1 (en) | 2006-01-19 | 2007-01-16 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1128285A1 true HK1128285A1 (en) | 2009-10-23 |
Family
ID=36572342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09105787.7A HK1128285A1 (en) | 2006-01-19 | 2009-06-26 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7834025B2 (xx) |
| EP (1) | EP1981875B1 (xx) |
| JP (1) | JP5137849B2 (xx) |
| CN (1) | CN101370803B (xx) |
| AU (1) | AU2007206950B2 (xx) |
| CA (1) | CA2635015C (xx) |
| DK (1) | DK1981875T3 (xx) |
| ES (1) | ES2481408T3 (xx) |
| HK (1) | HK1128285A1 (xx) |
| WO (1) | WO2007082882A1 (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003209727B2 (en) | 2002-03-13 | 2008-10-16 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| JP4674045B2 (ja) * | 2002-03-13 | 2011-04-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体 |
| CN100519527C (zh) * | 2002-03-13 | 2009-07-29 | 詹森药业有限公司 | 组织蛋白去乙酰酶抑制剂 |
| DE60321548D1 (de) * | 2002-03-13 | 2008-07-24 | Janssen Pharmaceutica Nv | Carbonylamino- derivativate als neue inhibitoren von histone deacetylase |
| RS51189B (sr) * | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
| PL1781639T3 (pl) | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
| AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| ATE509920T1 (de) * | 2005-10-27 | 2011-06-15 | Janssen Pharmaceutica Nv | Quadratsäurederivate als inhibitoren von histondeacetylase |
| DK1979328T3 (da) * | 2006-01-19 | 2013-03-25 | Janssen Pharmaceutica Nv | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere |
| WO2007082878A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
| EP1979326B1 (en) | 2006-01-19 | 2012-10-03 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| EP1979327A1 (en) | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US7834025B2 (en) * | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| DK2274301T3 (da) | 2008-03-27 | 2013-01-02 | Janssen Pharmaceutica Nv | Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylase |
| US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| CN103313992B (zh) * | 2011-01-12 | 2016-04-27 | 天堃医药科技（杭州）有限公司 | 具有hdac抑制作用的喜树碱衍生物 |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| DK2683371T3 (da) | 2011-03-09 | 2021-01-18 | Cereno Scient Ab | Forbindelser og fremgangsmåder til forbedring af forringet endogen fibrinolyse ved anvendelse af histondeacetylasehæmmere |
| AU2014228344C1 (en) | 2013-03-15 | 2019-02-07 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
| IL295374A (en) | 2020-02-04 | 2022-10-01 | Mindset Pharma Inc | 3-pyrrolidine indole derivatives as serotonergic psychedelics for the treatment of central nervous system disorders |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
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| BE637271A (xx) | 1963-04-04 | 1900-01-01 | ||
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| US3966743A (en) | 1968-07-23 | 1976-06-29 | Boehringer Mannheim G.M.B.H. | Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives |
| US4049811A (en) | 1968-07-23 | 1977-09-20 | Boehringer Mannheim G.M.B.H. | Compositions using cycloalkano-quinolone derivatives and their method of use |
| GB1345872A (en) | 1970-09-03 | 1974-02-06 | Wyeth John & Brother Ltd | Amino-and acylamino-pyridine and hydropyridine derivatives |
| DE2939292A1 (de) | 1979-09-28 | 1981-04-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | N-phenoxyalkylpiperidin-derivate, verfahrenn zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| PH17194A (en) | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| CA1183847A (en) | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| US4734418A (en) | 1984-12-14 | 1988-03-29 | Mitsui Petrochemical Industries, Ltd. | Quinazoline compounds and antihypertensives |
| HU206337B (en) | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
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| JP4674045B2 (ja) | 2002-03-13 | 2011-04-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体 |
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| KR101127201B1 (ko) | 2003-09-22 | 2012-04-12 | 에스*바이오 피티이 리미티드 | 벤즈이미다졸 유도체와 그의 제조방법 및 약학적 적용 |
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| PL1781639T3 (pl) * | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
| RS51189B (sr) | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
| AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
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| ATE509920T1 (de) | 2005-10-27 | 2011-06-15 | Janssen Pharmaceutica Nv | Quadratsäurederivate als inhibitoren von histondeacetylase |
| WO2007082878A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
| US7834025B2 (en) | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| DK1979328T3 (da) | 2006-01-19 | 2013-03-25 | Janssen Pharmaceutica Nv | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere |
| EP1981871B1 (en) | 2006-01-19 | 2011-12-28 | Janssen Pharmaceutica N.V. | Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase |
| EP1979327A1 (en) | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| EP1979326B1 (en) | 2006-01-19 | 2012-10-03 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| AU2007296259A1 (en) | 2006-09-15 | 2008-03-20 | Janssen Pharmaceutica Nv | Combinations of class-I specific histone deacetylase inhibitors with proteasome inhibitors |
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-
2007
- 2007-01-16 US US12/160,221 patent/US7834025B2/en active Active
- 2007-01-16 DK DK07703896.6T patent/DK1981875T3/da active
- 2007-01-16 CN CN2007800025793A patent/CN101370803B/zh active Active
- 2007-01-16 CA CA2635015A patent/CA2635015C/en active Active
- 2007-01-16 EP EP07703896.6A patent/EP1981875B1/en active Active
- 2007-01-16 WO PCT/EP2007/050381 patent/WO2007082882A1/en active Application Filing
- 2007-01-16 ES ES07703896.6T patent/ES2481408T3/es active Active
- 2007-01-16 AU AU2007206950A patent/AU2007206950B2/en not_active Ceased
- 2007-01-16 JP JP2008550744A patent/JP5137849B2/ja active Active
-
2009
- 2009-06-26 HK HK09105787.7A patent/HK1128285A1/xx not_active IP Right Cessation
-
2010
- 2010-10-05 US US12/898,564 patent/US8163765B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1981875A1 (en) | 2008-10-22 |
| US20110118291A1 (en) | 2011-05-19 |
| CA2635015C (en) | 2014-06-03 |
| JP5137849B2 (ja) | 2013-02-06 |
| CN101370803A (zh) | 2009-02-18 |
| EP1981875B1 (en) | 2014-04-16 |
| CN101370803B (zh) | 2012-12-12 |
| ES2481408T3 (es) | 2014-07-30 |
| US8163765B2 (en) | 2012-04-24 |
| JP2009523761A (ja) | 2009-06-25 |
| WO2007082882A1 (en) | 2007-07-26 |
| US20090018153A1 (en) | 2009-01-15 |
| AU2007206950A1 (en) | 2007-07-26 |
| CA2635015A1 (en) | 2007-07-26 |
| DK1981875T3 (da) | 2014-07-14 |
| AU2007206950B2 (en) | 2012-02-02 |
| US7834025B2 (en) | 2010-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180116 |