HK1119950A1 - 採用 -羥基他莫西芬預防和治療乳腺癌的製劑 - Google Patents
採用 -羥基他莫西芬預防和治療乳腺癌的製劑Info
- Publication number
- HK1119950A1 HK1119950A1 HK08113909.5A HK08113909A HK1119950A1 HK 1119950 A1 HK1119950 A1 HK 1119950A1 HK 08113909 A HK08113909 A HK 08113909A HK 1119950 A1 HK1119950 A1 HK 1119950A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- formulations
- prevention
- treatment
- breast cancer
- hydroxy tamoxifen
- Prior art date
Links
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 title 1
- 206010006187 Breast cancer Diseases 0.000 title 1
- 208000026310 Breast neoplasm Diseases 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45896303P | 2003-04-01 | 2003-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1119950A1 true HK1119950A1 (zh) | 2009-03-20 |
Family
ID=33131847
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06107310.2A HK1086193A1 (zh) | 2003-04-01 | 2006-06-28 | 採用 -羥基他莫西芬預防和治療乳腺癌 |
HK08113909.5A HK1119950A1 (zh) | 2003-04-01 | 2006-06-28 | 採用 -羥基他莫西芬預防和治療乳腺癌的製劑 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06107310.2A HK1086193A1 (zh) | 2003-04-01 | 2006-06-28 | 採用 -羥基他莫西芬預防和治療乳腺癌 |
Country Status (12)
Country | Link |
---|---|
US (2) | US7704516B2 (zh) |
EP (3) | EP1608353B1 (zh) |
JP (1) | JP5490346B2 (zh) |
AU (1) | AU2003294973B2 (zh) |
CA (1) | CA2519980C (zh) |
ES (3) | ES2456957T3 (zh) |
HK (2) | HK1086193A1 (zh) |
IL (1) | IL170807A (zh) |
MX (1) | MXPA05010597A (zh) |
NO (1) | NO333805B1 (zh) |
NZ (1) | NZ542499A (zh) |
WO (1) | WO2004087123A1 (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003303033B2 (en) * | 2002-12-18 | 2009-06-04 | Besins Healthcare Luxembourg Sarl | Treatment of mastalgia with 4-hydroxy tamoxifen |
US7485623B2 (en) * | 2002-12-18 | 2009-02-03 | Laboratoires Besins International Sa | Reduction of breast density with 4-hydroxy tamoxifen |
JP5490346B2 (ja) * | 2003-04-01 | 2014-05-14 | ブザン ヘルスケア ルクセンブルグ エスアーエールエル | 4−ヒドロキシタモキシフェンによる乳癌の予防および治療 |
CA2528431C (en) * | 2003-06-09 | 2012-09-18 | Northwestern University | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
EP1579857A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Chemically stable compositions of 4-hydroxy tamoxifen |
EP1579856A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
JP5072588B2 (ja) * | 2004-03-22 | 2012-11-14 | ラボラトワール ブザン アンテルナスィヨナル | 4−ヒドロキシタモキシフェンを用いた良性***疾患の治療および予防 |
EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
JP5047800B2 (ja) * | 2004-10-14 | 2012-10-10 | ラボラトワール ブザン アンテルナスィヨナル | 4‐ヒドロキシタモキシフェン系ゲル製剤 |
EP2147674A1 (en) * | 2008-07-24 | 2010-01-27 | Besins Healthcare | Transdermal pharmaceutical compositions comprising danazol |
US10080760B2 (en) * | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
CN106537139B (zh) | 2014-05-12 | 2019-04-16 | 奎斯特诊断投资公司 | 通过质谱法定量他莫昔芬及其代谢物 |
KR101571098B1 (ko) | 2014-07-16 | 2015-11-23 | 건국대학교 산학협력단 | 타목시펜 및 메틸설포닐메탄을 유효성분으로 포함하는 암 질환 예방 또는 치료용 약학 조성물 |
CN106459704B (zh) * | 2014-08-27 | 2020-08-25 | 东洋纺株式会社 | 低介电性粘合剂组合物 |
US10278976B2 (en) | 2014-12-12 | 2019-05-07 | Mira Dx, Inc. | Methods for treating or preventing cancer in a KRAS-variant patient and for diagnosing risk of developing multiple primary breast tumors |
PL3449017T3 (pl) * | 2016-04-29 | 2022-06-27 | Board Of Regents, The University Of Texas System | Ukierunkowane pomiary aktywności transkrypcyjnej związanej z receptorami hormonów |
MX2020002649A (es) | 2017-09-11 | 2020-09-25 | Atossa Therapeutics Inc | Metodos para hacer y usar endoxifeno. |
WO2019172109A1 (ja) | 2018-03-07 | 2019-09-12 | 東亞合成株式会社 | 接着剤組成物及びこれを用いた接着剤層付き積層体 |
WO2020023616A1 (en) * | 2018-07-24 | 2020-01-30 | Cornell University | Methods of upregulating tiparp as anticancer strategies |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2558373B1 (fr) | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee |
EP0287690B1 (de) * | 1987-04-21 | 1992-09-02 | HEUMANN PHARMA GMBH & CO | Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en |
US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
DE3836862A1 (de) | 1988-10-27 | 1990-05-03 | Schering Ag | Mittel zur transdermalen applikation von steroidhormonen |
US5189212A (en) * | 1990-09-07 | 1993-02-23 | University Of Georgia Research Foundation, Inc. | Triarylethylene carboxylic acids with estrogenic activity |
TW218849B (zh) * | 1991-05-17 | 1994-01-11 | Bristol Myers Squibb Co | |
US5613958A (en) | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
DE4407742C1 (de) | 1994-03-08 | 1995-06-22 | Hexal Pharma Gmbh | Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat |
US5720963A (en) * | 1994-08-26 | 1998-02-24 | Mary Kay Inc. | Barrier disruption treatments for structurally deteriorated skin |
ATE200978T1 (de) * | 1996-03-29 | 2001-05-15 | S W Patentverwertungs Ges M B | KOSMETIKUM BZW. KOSMETIKZUSAMMENSETZUNG ZUR GLÄTTUNG UND STRAFFUNG DER HAUT BEI GESTÖRTEM UNTERHAUT-BINDE-FETTGEWEBE, INSBESONDERE BEI DER ßCELLULITEß |
WO1999033451A2 (en) | 1997-12-23 | 1999-07-08 | Hexal Ag | Mixture and pharmaceutical composition comprising z-4-hydroxytamoxifen and cyclodextrin |
US6013270A (en) * | 1998-04-20 | 2000-01-11 | The Procter & Gamble Company | Skin care kit |
CN100482216C (zh) | 1999-12-16 | 2009-04-29 | 德马全兹股份有限公司 | 氢氧根释放剂增强透皮渗透的用途 |
DE10033853A1 (de) | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
AU2002340120A1 (en) * | 2001-10-04 | 2003-04-14 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
ES2330188T3 (es) | 2001-12-07 | 2009-12-07 | Besins Manufacturing Belgium | Composicion farmaceutica en forma de gel o de solucion a base de dihidrotestoterona, su procedimiento de preparacion y sus utilizaciones. |
AU2003303033B2 (en) * | 2002-12-18 | 2009-06-04 | Besins Healthcare Luxembourg Sarl | Treatment of mastalgia with 4-hydroxy tamoxifen |
US7485623B2 (en) | 2002-12-18 | 2009-02-03 | Laboratoires Besins International Sa | Reduction of breast density with 4-hydroxy tamoxifen |
JP5490346B2 (ja) * | 2003-04-01 | 2014-05-14 | ブザン ヘルスケア ルクセンブルグ エスアーエールエル | 4−ヒドロキシタモキシフェンによる乳癌の予防および治療 |
CA2528431C (en) | 2003-06-09 | 2012-09-18 | Northwestern University | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
US7968532B2 (en) | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
EP1579857A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Chemically stable compositions of 4-hydroxy tamoxifen |
EP1579856A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
EP1647271A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
-
2003
- 2003-12-15 JP JP2004570040A patent/JP5490346B2/ja not_active Expired - Lifetime
- 2003-12-15 ES ES08103007.4T patent/ES2456957T3/es not_active Expired - Lifetime
- 2003-12-15 US US10/734,638 patent/US7704516B2/en not_active Expired - Lifetime
- 2003-12-15 NZ NZ542499A patent/NZ542499A/en not_active IP Right Cessation
- 2003-12-15 WO PCT/EP2003/015029 patent/WO2004087123A1/en active Application Filing
- 2003-12-15 AU AU2003294973A patent/AU2003294973B2/en not_active Expired
- 2003-12-15 CA CA2519980A patent/CA2519980C/en not_active Expired - Lifetime
- 2003-12-15 EP EP03785958.4A patent/EP1608353B1/en not_active Expired - Lifetime
- 2003-12-15 MX MXPA05010597A patent/MXPA05010597A/es active IP Right Grant
- 2003-12-15 EP EP08103014.0A patent/EP1941871B1/en not_active Expired - Lifetime
- 2003-12-15 ES ES03785958.4T patent/ES2483896T3/es not_active Expired - Lifetime
- 2003-12-15 ES ES08103014.0T patent/ES2456958T3/es not_active Expired - Lifetime
- 2003-12-15 EP EP08103007.4A patent/EP1952810B1/en not_active Expired - Lifetime
-
2005
- 2005-09-12 IL IL170807A patent/IL170807A/en active IP Right Grant
- 2005-09-30 NO NO20054526A patent/NO333805B1/no not_active IP Right Cessation
-
2006
- 2006-06-28 HK HK06107310.2A patent/HK1086193A1/zh not_active IP Right Cessation
- 2006-06-28 HK HK08113909.5A patent/HK1119950A1/zh not_active IP Right Cessation
-
2009
- 2009-01-14 US US12/353,890 patent/US8475814B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
HK1086193A1 (zh) | 2006-09-15 |
EP1952810B1 (en) | 2014-01-08 |
EP1608353A1 (en) | 2005-12-28 |
US20090186944A1 (en) | 2009-07-23 |
CA2519980C (en) | 2012-04-10 |
US7704516B2 (en) | 2010-04-27 |
EP1941871B1 (en) | 2014-01-08 |
ES2456957T3 (es) | 2014-04-24 |
EP1952810A1 (en) | 2008-08-06 |
EP1941871A1 (en) | 2008-07-09 |
JP5490346B2 (ja) | 2014-05-14 |
IL170807A (en) | 2014-08-31 |
JP2006514967A (ja) | 2006-05-18 |
EP1608353B1 (en) | 2014-04-30 |
NO20054526L (no) | 2005-09-30 |
ES2483896T3 (es) | 2014-08-08 |
NO333805B1 (no) | 2013-09-16 |
AU2003294973A1 (en) | 2004-10-25 |
US8475814B2 (en) | 2013-07-02 |
NZ542499A (en) | 2008-10-31 |
ES2456958T3 (es) | 2014-04-24 |
WO2004087123A1 (en) | 2004-10-14 |
US20050031695A1 (en) | 2005-02-10 |
MXPA05010597A (es) | 2006-03-09 |
CA2519980A1 (en) | 2004-10-14 |
AU2003294973B2 (en) | 2010-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20231216 |