ES2483896T3 - Prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen - Google Patents
Prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen Download PDFInfo
- Publication number
- ES2483896T3 ES2483896T3 ES03785958.4T ES03785958T ES2483896T3 ES 2483896 T3 ES2483896 T3 ES 2483896T3 ES 03785958 T ES03785958 T ES 03785958T ES 2483896 T3 ES2483896 T3 ES 2483896T3
- Authority
- ES
- Spain
- Prior art keywords
- breast cancer
- hydroxy tamoxifen
- prevention
- medication
- sine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 6
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 6
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 abstract 1
- 102000000872 ATM Human genes 0.000 abstract 1
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 abstract 1
- 102000036365 BRCA1 Human genes 0.000 abstract 1
- 108700020463 BRCA1 Proteins 0.000 abstract 1
- 101150072950 BRCA1 gene Proteins 0.000 abstract 1
- 102000052609 BRCA2 Human genes 0.000 abstract 1
- 108700020462 BRCA2 Proteins 0.000 abstract 1
- 101150008921 Brca2 gene Proteins 0.000 abstract 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 abstract 1
- 206010012186 Delayed delivery Diseases 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000008135 aqueous vehicle Substances 0.000 abstract 1
- 238000001574 biopsy Methods 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003349 gelling agent Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Medicamento para uso para la prevención de cáncer de seno en un paciente en mayor riesgo de desarrollar cáncer de seno, en donde dicho medicamento es una composición hidroalcohólica para administración percutánea que contiene 4-hidroxi tamoxifen, miristato de isopropilo como potenciador de la penetración, un vehículo acuoso, un vehículo alcohólico y un agente gelificante, en donde el 4-hidroxi tamoxifen es para administrado en una cantidad de aproximadamente 0.25 a 2.0 mg/seno, preferiblemente aproximadamente 0.5 a 1.0 mg/seno por día, en donde dicho incremento del riesgo para desarrollar cáncer de seno es seleccionado de la historia familiar de cáncer de seno; historia personales de cáncer de seno; detección por biopsia de seno previa de hiperplasia atípica; irradiación del seno previa; factores de riesgo genéticos seleccionados de BRCA1, BRCA2, ATM, CHEK-2 y las mutaciones de p53; partos retrasados hasta después de la edad de 30 años
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45896303P | 2003-04-01 | 2003-04-01 | |
US458963P | 2003-04-01 | ||
PCT/EP2003/015029 WO2004087123A1 (en) | 2003-04-01 | 2003-12-15 | Prevention and treatment of breast cancer with 4-hydroxy tamoxifen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2483896T3 true ES2483896T3 (es) | 2014-08-08 |
Family
ID=33131847
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES03785958.4T Expired - Lifetime ES2483896T3 (es) | 2003-04-01 | 2003-12-15 | Prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen |
ES08103014.0T Expired - Lifetime ES2456958T3 (es) | 2003-04-01 | 2003-12-15 | Formulaciones para prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen |
ES08103007.4T Expired - Lifetime ES2456957T3 (es) | 2003-04-01 | 2003-12-15 | Tratamiento de cáncer de seno con 4-hidroxitamoxifen |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08103014.0T Expired - Lifetime ES2456958T3 (es) | 2003-04-01 | 2003-12-15 | Formulaciones para prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen |
ES08103007.4T Expired - Lifetime ES2456957T3 (es) | 2003-04-01 | 2003-12-15 | Tratamiento de cáncer de seno con 4-hidroxitamoxifen |
Country Status (12)
Country | Link |
---|---|
US (2) | US7704516B2 (es) |
EP (3) | EP1608353B1 (es) |
JP (1) | JP5490346B2 (es) |
AU (1) | AU2003294973B2 (es) |
CA (1) | CA2519980C (es) |
ES (3) | ES2483896T3 (es) |
HK (2) | HK1119950A1 (es) |
IL (1) | IL170807A (es) |
MX (1) | MXPA05010597A (es) |
NO (1) | NO333805B1 (es) |
NZ (1) | NZ542499A (es) |
WO (1) | WO2004087123A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004054558A2 (en) * | 2002-12-18 | 2004-07-01 | Laboratoires Besins International | Reduction of breast density with 4-hydroxy tamoxifen |
SI1572178T1 (sl) * | 2002-12-18 | 2006-10-31 | Besins Int Lab | Zdravljenje mastalgije s 4-hidroksi-tamoksifenom |
ES2483896T3 (es) * | 2003-04-01 | 2014-08-08 | Besins Healthcare Luxembourg Sarl | Prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen |
CA2528431C (en) * | 2003-06-09 | 2012-09-18 | Northwestern University | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
US7968532B2 (en) * | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
PT1748770E (pt) * | 2004-03-22 | 2008-07-16 | Besins Int Lab | Tratamento e prevenção de doença benigna da mama com 4-hidroxi-tamoxifeno |
US7507769B2 (en) | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
EP1579856A1 (en) * | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
US20050208139A1 (en) * | 2004-03-22 | 2005-09-22 | Ascend Therapeutics, Inc. | Chemically stable compositions of 4-hydroxy tamoxifen |
EP1647271A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
EP1799201B1 (en) * | 2004-10-14 | 2008-11-26 | Laboratoires Besins International | 4-hydroxy tamoxifen gel formulations |
EP2147674A1 (en) * | 2008-07-24 | 2010-01-27 | Besins Healthcare | Transdermal pharmaceutical compositions comprising danazol |
US10080760B2 (en) * | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
CA2948823C (en) * | 2014-05-12 | 2020-09-22 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
KR101571098B1 (ko) | 2014-07-16 | 2015-11-23 | 건국대학교 산학협력단 | 타목시펜 및 메틸설포닐메탄을 유효성분으로 포함하는 암 질환 예방 또는 치료용 약학 조성물 |
JP6645431B2 (ja) * | 2014-08-27 | 2020-02-14 | 東洋紡株式会社 | 低誘電接着剤組成物 |
WO2016094854A2 (en) * | 2014-12-12 | 2016-06-16 | Miradx | Methods for treating or preventing cancer in a kras-variant patient and for diagnosing risk of developing multiple primary breast tumors |
EP4029950A1 (en) * | 2016-04-29 | 2022-07-20 | Board of Regents, The University of Texas System | Targeted measure of transcriptional activity related to hormone receptors |
IL272924B2 (en) | 2017-09-11 | 2024-01-01 | Atossa Therapeutics Inc | Methods for preparing and using endoxifen |
US20210009865A1 (en) | 2018-03-07 | 2021-01-14 | Toagosei Co., Ltd. | Adhesive composition, and adhesive layer-equipped layered product using same |
WO2020023616A1 (en) * | 2018-07-24 | 2020-01-30 | Cornell University | Methods of upregulating tiparp as anticancer strategies |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2558373B1 (fr) * | 1984-01-20 | 1987-07-03 | Mauvais Jarvis Pierre | Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee |
EP0287690B1 (de) * | 1987-04-21 | 1992-09-02 | HEUMANN PHARMA GMBH & CO | Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en |
US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
DE3836862A1 (de) | 1988-10-27 | 1990-05-03 | Schering Ag | Mittel zur transdermalen applikation von steroidhormonen |
US5189212A (en) * | 1990-09-07 | 1993-02-23 | University Of Georgia Research Foundation, Inc. | Triarylethylene carboxylic acids with estrogenic activity |
TW218849B (es) * | 1991-05-17 | 1994-01-11 | Bristol Myers Squibb Co | |
US5613958A (en) | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
DE4407742C1 (de) | 1994-03-08 | 1995-06-22 | Hexal Pharma Gmbh | Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat |
US5720963A (en) * | 1994-08-26 | 1998-02-24 | Mary Kay Inc. | Barrier disruption treatments for structurally deteriorated skin |
ES2156361T5 (es) * | 1996-03-29 | 2012-12-26 | Keyvest Gmbh | Cosmético o bien composición cosmética para el alisado y la tersura de la piel en el caso de tejido adiposo afectado, en especial en el caso de la "celulitis" |
AU2513899A (en) | 1997-12-23 | 1999-07-19 | Hexal Ag | Mixture and pharmaceutical composition comprising z-4-hydroxytamoxifen and cyclodextrin |
US6013270A (en) * | 1998-04-20 | 2000-01-11 | The Procter & Gamble Company | Skin care kit |
EP1239845B1 (en) | 1999-12-16 | 2005-03-16 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
DE10033853A1 (de) | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
WO2003028667A2 (en) * | 2001-10-04 | 2003-04-10 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
PT1317921E (pt) | 2001-12-07 | 2009-11-06 | Besins Mfg Belgium | Composição farmacêutica sob a forma de gel ou de solução à base de di-hidrotestosterona, seu processo de preparação e suas utilizações |
WO2004054558A2 (en) * | 2002-12-18 | 2004-07-01 | Laboratoires Besins International | Reduction of breast density with 4-hydroxy tamoxifen |
SI1572178T1 (sl) * | 2002-12-18 | 2006-10-31 | Besins Int Lab | Zdravljenje mastalgije s 4-hidroksi-tamoksifenom |
ES2483896T3 (es) * | 2003-04-01 | 2014-08-08 | Besins Healthcare Luxembourg Sarl | Prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen |
CA2528431C (en) | 2003-06-09 | 2012-09-18 | Northwestern University | Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen |
US7968532B2 (en) | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
US7507769B2 (en) * | 2004-03-22 | 2009-03-24 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
US20050208139A1 (en) | 2004-03-22 | 2005-09-22 | Ascend Therapeutics, Inc. | Chemically stable compositions of 4-hydroxy tamoxifen |
EP1579856A1 (en) | 2004-03-22 | 2005-09-28 | Laboratoires Besins International | Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen |
EP1647271A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoires Besins International | 4-Hydroxy tamoxifen gel formulations |
-
2003
- 2003-12-15 ES ES03785958.4T patent/ES2483896T3/es not_active Expired - Lifetime
- 2003-12-15 ES ES08103014.0T patent/ES2456958T3/es not_active Expired - Lifetime
- 2003-12-15 CA CA2519980A patent/CA2519980C/en not_active Expired - Lifetime
- 2003-12-15 NZ NZ542499A patent/NZ542499A/en not_active IP Right Cessation
- 2003-12-15 WO PCT/EP2003/015029 patent/WO2004087123A1/en active Application Filing
- 2003-12-15 US US10/734,638 patent/US7704516B2/en not_active Expired - Lifetime
- 2003-12-15 EP EP03785958.4A patent/EP1608353B1/en not_active Expired - Lifetime
- 2003-12-15 JP JP2004570040A patent/JP5490346B2/ja not_active Expired - Lifetime
- 2003-12-15 AU AU2003294973A patent/AU2003294973B2/en not_active Expired
- 2003-12-15 EP EP08103007.4A patent/EP1952810B1/en not_active Expired - Lifetime
- 2003-12-15 MX MXPA05010597A patent/MXPA05010597A/es active IP Right Grant
- 2003-12-15 EP EP08103014.0A patent/EP1941871B1/en not_active Expired - Lifetime
- 2003-12-15 ES ES08103007.4T patent/ES2456957T3/es not_active Expired - Lifetime
-
2005
- 2005-09-12 IL IL170807A patent/IL170807A/en active IP Right Grant
- 2005-09-30 NO NO20054526A patent/NO333805B1/no not_active IP Right Cessation
-
2006
- 2006-06-28 HK HK08113909.5A patent/HK1119950A1/xx not_active IP Right Cessation
- 2006-06-28 HK HK06107310.2A patent/HK1086193A1/xx not_active IP Right Cessation
-
2009
- 2009-01-14 US US12/353,890 patent/US8475814B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20050031695A1 (en) | 2005-02-10 |
ES2456958T3 (es) | 2014-04-24 |
EP1952810A1 (en) | 2008-08-06 |
NO333805B1 (no) | 2013-09-16 |
EP1941871B1 (en) | 2014-01-08 |
ES2456957T3 (es) | 2014-04-24 |
NZ542499A (en) | 2008-10-31 |
EP1608353B1 (en) | 2014-04-30 |
CA2519980C (en) | 2012-04-10 |
JP2006514967A (ja) | 2006-05-18 |
US20090186944A1 (en) | 2009-07-23 |
AU2003294973B2 (en) | 2010-05-13 |
NO20054526L (no) | 2005-09-30 |
AU2003294973A1 (en) | 2004-10-25 |
US7704516B2 (en) | 2010-04-27 |
EP1608353A1 (en) | 2005-12-28 |
CA2519980A1 (en) | 2004-10-14 |
JP5490346B2 (ja) | 2014-05-14 |
HK1086193A1 (en) | 2006-09-15 |
EP1941871A1 (en) | 2008-07-09 |
EP1952810B1 (en) | 2014-01-08 |
WO2004087123A1 (en) | 2004-10-14 |
HK1119950A1 (en) | 2009-03-20 |
US8475814B2 (en) | 2013-07-02 |
MXPA05010597A (es) | 2006-03-09 |
IL170807A (en) | 2014-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2483896T3 (es) | Prevención y tratamiento de cáncer de seno con 4-hidroxi tamoxifen | |
Gao et al. | Cerium oxide nanoparticles in cancer | |
Hirakawa et al. | Surgical site infection in clean-contaminated head and neck cancer surgery: risk factors and prognosis | |
BRPI0607168A2 (pt) | terapia de combinação parenteral, composição farmacêutica, processo para preparar uma composição farmacêutica e método de tratamento | |
BRPI0415007A (pt) | método para tratar, prevenir, modificar ou administrar dor, e, composição farmacêutica | |
Kini et al. | An unusual occurrence of epidermoid cyst in the buccal mucosa: a case report with review of literature | |
AR078224A1 (es) | Composicon para el tratamiento del cancer de prostata | |
JP2006514967A5 (es) | ||
BRPI0411079A (pt) | composições farmacêuticas compreendendo atorvastatina, fabricadas sem granulação | |
Piraccini et al. | Ciclopirox hydroxypropyl chitosan (HPCH) nail lacquer: a review of its use in onychomycosis | |
DE60036915D1 (de) | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln | |
Kästner et al. | Removal of polyacrylamide gel (Aquamid®) from the lip as a solution for late-onset complications: our 8-year experience | |
Durbec et al. | Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx | |
Khan et al. | Impact of gold nanoparticles on colon cancer treatment and diagnosis | |
ATE499378T1 (de) | Anthracyclinderivate | |
US20110117008A1 (en) | Use of avicins to deliver therapeutic and diagnostic agents | |
US20060013862A1 (en) | Onychomycosis: a new process for cure | |
CU23475A1 (es) | Composición farmacéutica conteniendo fragmentos polipeptídicos de serralisinas | |
Kravchenko et al. | PHARMACOKINETIC SUBSTANTIATION OF THE THERAPEUTIC EFFICACY OF ANTISEPTIC PREPARATION CYDIPOL IN TREATMENT OF PROSTATITIS | |
ES2308744T3 (es) | Utilizacion del gluconato de zinc para el tratamiento de hidradenita supurada. | |
Goosmann et al. | Treating sinonasal crusting and infection after palatal and sinonasal cancer resection with topical antibiotic irrigations | |
Bharangar et al. | Foreign body in paranasal sinus: a unique accident and a miraculous escape for the patient | |
Guozhong | Joseph Needham and Rewi Alley's China complexes | |
Poddar et al. | Newer Therapies in Dermatophytosis | |
CN104606295A (zh) | 非抗生素类抗真菌外用药 |