HK1092708A1 - Polyacetal drug conjugates as release system - Google Patents

Polyacetal drug conjugates as release system

Info

Publication number
HK1092708A1
HK1092708A1 HK06113449.4A HK06113449A HK1092708A1 HK 1092708 A1 HK1092708 A1 HK 1092708A1 HK 06113449 A HK06113449 A HK 06113449A HK 1092708 A1 HK1092708 A1 HK 1092708A1
Authority
HK
Hong Kong
Prior art keywords
linker
occurrence
succinamide
polyacetal
release system
Prior art date
Application number
HK06113449.4A
Other languages
English (en)
Inventor
Mikhail I Papisov
Alexander Yurkovetskiy
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of HK1092708A1 publication Critical patent/HK1092708A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Polymers & Plastics (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK06113449.4A 2003-09-05 2006-12-06 Polyacetal drug conjugates as release system HK1092708A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50057103P 2003-09-05 2003-09-05
PCT/US2004/029130 WO2005023294A2 (en) 2003-09-05 2004-09-04 Polyacetal drug conjugates as release system

Publications (1)

Publication Number Publication Date
HK1092708A1 true HK1092708A1 (en) 2007-02-16

Family

ID=34272970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06113449.4A HK1092708A1 (en) 2003-09-05 2006-12-06 Polyacetal drug conjugates as release system

Country Status (10)

Country Link
US (4) US7790150B2 (ja)
EP (1) EP1667726B1 (ja)
JP (3) JP5537763B2 (ja)
AT (1) ATE507845T1 (ja)
AU (1) AU2004270251B2 (ja)
CA (1) CA2537993C (ja)
DE (1) DE602004032553D1 (ja)
ES (1) ES2365918T3 (ja)
HK (1) HK1092708A1 (ja)
WO (1) WO2005023294A2 (ja)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106098B2 (en) * 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
DE60323936D1 (de) 2002-01-14 2008-11-20 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
JP4800614B2 (ja) * 2002-07-19 2011-10-26 ザ ジェネラル ホスピタル コーポレイション オキシム結合体、およびそれらの形成および使用のための方法
EP1667726B1 (en) 2003-09-05 2011-05-04 The General Hospital Corporation Polyacetal drug conjugates as release system
US8252846B2 (en) * 2005-05-10 2012-08-28 Emory University Strategies for delivery of active agents using micelles and particles
ATE541875T1 (de) * 2005-05-10 2012-02-15 Univ Emory Strategien zur freisetzung von wirkstoffen unter verwendung von mizellen und partikeln
WO2007098041A1 (en) 2006-02-17 2007-08-30 Medtronic, Inc. Polyketal polymers, and methods of making and using same
EP2146747A1 (en) * 2007-04-12 2010-01-27 Emory University Novel strategies for delivery of active agents using micelles and particles
US20080255175A1 (en) * 2007-04-16 2008-10-16 Lam Marina K Anti-cancer agents, compositions and methods of treating cancers
BRPI0820229A2 (pt) * 2007-11-28 2017-05-09 A Stevenson Cheri conjugados de análogos de fumagilina biodegradáveis biocompatíveis
WO2010068759A1 (en) * 2008-12-10 2010-06-17 Mersana Therapeutics, Inc. Pharmaceutical formulations of biodegradable biocompatible camptothecin-polymer conjugates
US11090387B2 (en) 2008-12-22 2021-08-17 The Trustees Of The University Of Pennsylvania Hydrolytically degradable polysaccharide hydrogels
EP2435053B1 (en) 2009-05-28 2018-11-14 Mersana Therapeutics, Inc. Polyal drug conjugates comprising variable rate-releasing linkers
US20120171118A1 (en) * 2009-06-12 2012-07-05 The General Hospital Corporation Treatment of meningeal and neural diseases
WO2011120053A1 (en) 2010-03-26 2011-09-29 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
US9486404B2 (en) 2011-03-28 2016-11-08 The Trustees Of The University Of Pennsylvania Infarction treatment compositions and methods
TWI597065B (zh) * 2011-06-10 2017-09-01 梅爾莎納醫療公司 蛋白質－聚合物－藥物共軛體
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2014008375A1 (en) * 2012-07-05 2014-01-09 Mersana Therapeutics, Inc. Terminally modified polymers and conjugates thereof
US10226535B2 (en) 2012-12-10 2019-03-12 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
AU2013359506B2 (en) * 2012-12-10 2018-05-24 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
EP2931316B1 (en) 2012-12-12 2019-02-20 Mersana Therapeutics, Inc. Hydroxyl-polymer-drug-protein conjugates
WO2014160360A1 (en) * 2013-03-14 2014-10-02 Mersana Therapeutics Inc. Tubulysin compounds and conjugates thereof
JP6427564B2 (ja) 2013-10-11 2018-11-21 アサナ・バイオサイエンシズ，リミテッド・ライアビリティ・カンパニー タンパク質−ポリマー−薬物共役体
JP6420331B2 (ja) * 2013-10-11 2018-11-07 メルサナ セラピューティクス，インコーポレイティド タンパク質−高分子−薬剤コンジュゲート
WO2015157578A2 (en) * 2014-04-10 2015-10-15 Af Chemicals, Llc Affinity medicant conjugates
JP6149810B2 (ja) * 2014-06-13 2017-06-21 株式会社島津製作所 代謝物解析システム及び代謝物解析方法
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗ｈｅｒ２表位之單株抗體及其使用之方法
US11324827B2 (en) 2014-10-01 2022-05-10 Xiamen Sinopeg Biotech Co., Ltd. Multifunctionalized polyethylene glycol derivative and preparation method therefor
CN104877127B (zh) 2015-06-23 2017-11-10 厦门赛诺邦格生物科技股份有限公司 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质
US11433136B2 (en) * 2015-12-18 2022-09-06 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
MX2018011204A (es) 2016-03-15 2019-03-07 Mersana Therapeutics Inc Conjugados de anticuerpo-farmaco dirigidos a napi2b y sus metodos de uso.
CN109563215B (zh) * 2016-06-03 2021-11-19 诺灵生物医药科技(北京)有限公司 聚合物连接子及其用途
US20180271996A1 (en) 2017-02-28 2018-09-27 Mersana Therapeutics, Inc. Combination therapies of her2-targeted antibody-drug conjugates
KR101875321B1 (ko) 2017-03-15 2018-07-05 인하대학교 산학협력단 트리펩타이드 및 다이펩타이드 유도체, 이의 제조방법, 이를 포함하는 화학센서 및 이를 이용한 알루미늄 이온 및 3가 금속이온을 비례 형광형으로 검출하는 방법
TW201905037A (zh) 2017-06-22 2019-02-01 美商梅爾莎納醫療公司 藥物攜帶聚合物支架及蛋白質聚合物藥物共軛物之製造方法
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US152790A (en) * 1874-07-07 Improvement in explosive compounds
US193211A (en) * 1877-07-17 Improvement in car-repiacers
US93951A (en) * 1869-08-24 Improved die fob forming- carriage-shaft shackles
US4793986A (en) 1987-02-25 1988-12-27 Johnson Matthey, Inc. Macromolecular platinum antitumor compounds
JPH01190636A (ja) 1988-01-22 1989-07-31 Green Cross Corp:The 制癌作用物質複合体
US5075222A (en) * 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
US6610841B1 (en) 1997-12-18 2003-08-26 Gilead Sciences, Inc. Nucleotide-based prodrugs
EP0654973A4 (en) * 1992-07-21 1995-08-09 Gen Hospital Corp LYPHATIC TISSUE DRUG ADMINISTRATION SYSTEM.
US5624803A (en) * 1993-10-14 1997-04-29 The Regents Of The University Of California In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5612037A (en) * 1994-07-26 1997-03-18 Connaught Laboratories, Inc. Influenza virus subunit conjugates
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
EP0821001A4 (en) * 1995-03-31 2002-07-17 Drug Delivery System Inst Ltd AMIDITY DERIVATIVES AND OLIGONUCLEOTIDE DERIVATIVES
US5811510A (en) 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
AU6028396A (en) 1995-06-07 1996-12-30 Amgen, Inc. Ob protein compositions and method
AU735900B2 (en) 1996-03-12 2001-07-19 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6294170B1 (en) * 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
GB9814527D0 (en) * 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
US6818630B1 (en) * 1999-06-18 2004-11-16 Ml Laboratories Plc Biologically active materials
IL131074A0 (en) 1999-07-23 2001-03-19 Polygene Ltd A biodegradable polycation composition for delivery of an anionic macromolecule
US6822086B1 (en) * 1999-08-09 2004-11-23 The General Hospital Corporation Drug-carrier complexes and methods of use thereof
US8106098B2 (en) * 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
WO2001010468A2 (en) 1999-08-09 2001-02-15 The General Hospital Corporation Drug-carrier complexes and methods of use thereof
WO2002020663A2 (en) * 2000-09-06 2002-03-14 Ap Pharma, Inc. Degradable polyacetal polymers
DE60323936D1 (de) * 2002-01-14 2008-11-20 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
ATE441706T1 (de) * 2002-02-20 2009-09-15 Gen Hospital Corp Konjugate mit biologisch abbaubarem polymer und verwendung dafür
JP4800614B2 (ja) * 2002-07-19 2011-10-26 ザ ジェネラル ホスピタル コーポレイション オキシム結合体、およびそれらの形成および使用のための方法
AU2003256613A1 (en) * 2002-07-19 2004-02-09 Amgen Inc. Protein conjugates with a water-soluble biocompatible, biogradable polymer
BR122012021252B8 (pt) * 2002-09-06 2021-05-25 Cerulean Pharma Inc polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência
WO2004089311A2 (en) 2003-03-31 2004-10-21 Vectramed, Inc. Polymeric drug agents for the treatment of fibrotic disorders
EP1667726B1 (en) * 2003-09-05 2011-05-04 The General Hospital Corporation Polyacetal drug conjugates as release system
BRPI0820229A2 (pt) * 2007-11-28 2017-05-09 A Stevenson Cheri conjugados de análogos de fumagilina biodegradáveis biocompatíveis
US20120171118A1 (en) 2009-06-12 2012-07-05 The General Hospital Corporation Treatment of meningeal and neural diseases

Also Published As

Publication number Publication date
US8101164B2 (en) 2012-01-24
DE602004032553D1 (de) 2011-06-16
WO2005023294A3 (en) 2005-06-09
ES2365918T3 (es) 2011-10-13
JP5537763B2 (ja) 2014-07-02
JP2014111657A (ja) 2014-06-19
US20110059010A1 (en) 2011-03-10
EP1667726A2 (en) 2006-06-14
US20120289535A1 (en) 2012-11-15
US8546419B2 (en) 2013-10-01
US20070190018A1 (en) 2007-08-16
CA2537993A1 (en) 2005-03-17
AU2004270251A1 (en) 2005-03-17
AU2004270251B2 (en) 2011-03-31
JP2011153159A (ja) 2011-08-11
US20120004255A1 (en) 2012-01-05
JP2007504253A (ja) 2007-03-01
WO2005023294A2 (en) 2005-03-17
CA2537993C (en) 2012-08-28
US7790150B2 (en) 2010-09-07
US8247427B2 (en) 2012-08-21
EP1667726B1 (en) 2011-05-04
ATE507845T1 (de) 2011-05-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180901