HK1068332A1 - Pyrane derivatives as both ace-and nep-inhibitors - Google Patents

Pyrane derivatives as both ace-and nep-inhibitors

Info

Publication number
HK1068332A1
HK1068332A1 HK04109973A HK04109973A HK1068332A1 HK 1068332 A1 HK1068332 A1 HK 1068332A1 HK 04109973 A HK04109973 A HK 04109973A HK 04109973 A HK04109973 A HK 04109973A HK 1068332 A1 HK1068332 A1 HK 1068332A1
Authority
HK
Hong Kong
Prior art keywords
ace
nep
inhibitors
sub
pyrane derivatives
Prior art date
Application number
HK04109973A
Other languages
English (en)
Inventor
Cynthia Anne Fink
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1068332A1 publication Critical patent/HK1068332A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HK04109973A 2001-09-21 2004-12-15 Pyrane derivatives as both ace-and nep-inhibitors HK1068332A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32382501P 2001-09-21 2001-09-21
PCT/EP2002/010608 WO2003027091A1 (fr) 2001-09-21 2002-09-20 Derives du pyranne utilises comme inhibiteurs de ace et nep

Publications (1)

Publication Number Publication Date
HK1068332A1 true HK1068332A1 (en) 2005-04-29

Family

ID=23260883

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04109973A HK1068332A1 (en) 2001-09-21 2004-12-15 Pyrane derivatives as both ace-and nep-inhibitors

Country Status (12)

Country Link
US (2) US7071169B2 (fr)
EP (1) EP1430045B1 (fr)
JP (1) JP4263095B2 (fr)
CN (1) CN1304415C (fr)
AT (1) ATE342261T1 (fr)
BR (1) BR0212899A (fr)
CA (1) CA2456281A1 (fr)
DE (1) DE60215368T2 (fr)
ES (1) ES2274106T3 (fr)
HK (1) HK1068332A1 (fr)
PT (1) PT1430045E (fr)
WO (1) WO2003027091A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1304415C (zh) 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
FI20040674A0 (fi) * 2004-05-12 2004-05-12 Orion Corp Menetelmä tromboembolisten sairauksien estoon
AU2005315608B2 (en) * 2004-12-15 2011-03-31 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors
WO2006087371A1 (fr) * 2005-02-18 2006-08-24 Solvay Pharmaceuticals Gmbh Compositions pharmaceutiques comprenant des inhibiteurs de l'endopeptidase neutre (epn), des inhibiteurs du systeme de production de l’endotheline endogene ainsi que des diuretiques
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
EP1897879A3 (fr) 2005-03-31 2008-06-11 Speedel Experimenta AG Pipéridines 2,4,5-substituées comme inhibiteurs de la rénine
WO2007080884A1 (fr) * 2006-01-11 2007-07-19 Seikagaku Corporation Derive d'ester d'acide cycloalkylcarbonylamino et son procede de production
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
CA2697057A1 (fr) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapie pour complications du diabete
WO2009127251A1 (fr) * 2008-04-16 2009-10-22 Novartis Ag Combinaisons renfermant un inhibiteur de la rénine
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211648A (ja) * 1990-07-27 1992-08-03 Nippon Kayaku Co Ltd ケト酸アミド誘導体
EP0655461B1 (fr) 1993-11-16 2000-06-07 Novartis AG Dérivés d'amino acide cycliques ayant une activité inhibante d'ACE et NEP
US5432186A (en) 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
PT1080104E (pt) 1998-04-23 2005-06-30 Novartis Ag Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina
CA2323691A1 (fr) * 1998-04-23 1999-11-04 Denton Wade Hoyer Certains inhibiteurs thiol d'une enzyme de conversion d'endotheline
AU2001254776A1 (en) 2000-04-06 2001-10-23 Novartis Ag Organic compounds
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CN1304415C (zh) 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物

Also Published As

Publication number Publication date
JP4263095B2 (ja) 2009-05-13
DE60215368D1 (de) 2006-11-23
BR0212899A (pt) 2004-11-03
CN1304415C (zh) 2007-03-14
CN1555372A (zh) 2004-12-15
PT1430045E (pt) 2007-01-31
US7071169B2 (en) 2006-07-04
US20040266698A1 (en) 2004-12-30
ES2274106T3 (es) 2007-05-16
WO2003027091A1 (fr) 2003-04-03
ATE342261T1 (de) 2006-11-15
EP1430045B1 (fr) 2006-10-11
CA2456281A1 (fr) 2003-04-03
US20060194742A1 (en) 2006-08-31
EP1430045A1 (fr) 2004-06-23
JP2005504099A (ja) 2005-02-10
DE60215368T2 (de) 2007-08-16

Similar Documents

Publication Publication Date Title
MY141661A (en) 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
MY133473A (en) Haterocyclic glycyl beta-alanine derivatives.
HK1068136A1 (en) Muscarinic antagonists
CA2407100A1 (fr) 1-aroyle-piperidinyle benzamidines
WO2003006425A3 (fr) Nouveaux composes convenant comme anti-inflammatoires, immuno-modulateurs et anti-proliferants
CA2343236A1 (fr) Derives de 4,4-biarylpiperidine
HK1051500A1 (en) Cell adhesion inhibitors
HRP20031003A2 (en) 4'-substituted nukleosides
JO2372B1 (en) Source drugs of 4-phenylpyridine derivatives
WO2001087882A3 (fr) Derives de pyrrolopyridinone substitues utiles en tant qu'inhibiteurs de la phosphodiesterase
HK1068332A1 (en) Pyrane derivatives as both ace-and nep-inhibitors
NZ279397A (en) Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives and pharmaceutucal compositions
BG105731A (en) 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
NO983444D0 (no) Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
SI1651596T1 (sl) Novi derivati ditiobis aminobutan sulfonatov in sestavki ki jih vsebujejo
CA2299036A1 (fr) Derives de 4-phenyl-4-heteroarylpiperidine
MXPA03010259A (es) Nuevos derivados de 5-tio-ss-d-xilopiranosida, procedimiento de preparacion, composiciones farmaceuticas que los contienen y el uso terapeutico de los mismos.
EP1057829A4 (fr) Dérivés de la pyrimidine condensés et compositions pharmaceutiques les contenant
ATE252546T1 (de) 3-(3-hydroxyphenyl)-3-amino-propionamidderivate
WO2000037465A3 (fr) Derives de swainsonine, procedes de preparation et utilisations comme agents therapeutiques
WO2003104189A3 (fr) Composes
MY138319A (en) 1,5-benzodiazepine derivatives
IL166313A0 (en) Indoline derivatives and pharmaceutical compositions containing the same
MY128457A (en) 2-aminocarbonyl-9h-purine derivatives
BR9915898A (pt) Compostos, composição farmacêutica, e, utilização de um composto

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100920