HK1068266A1 - Use of nk-1 receptor antagonists for the treatmentof brain, spinal or nerve injury - Google Patents
Use of nk-1 receptor antagonists for the treatmentof brain, spinal or nerve injuryInfo
- Publication number
- HK1068266A1 HK1068266A1 HK05100430A HK05100430A HK1068266A1 HK 1068266 A1 HK1068266 A1 HK 1068266A1 HK 05100430 A HK05100430 A HK 05100430A HK 05100430 A HK05100430 A HK 05100430A HK 1068266 A1 HK1068266 A1 HK 1068266A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatmentof
- spinal
- brain
- receptor antagonists
- nerve injury
- Prior art date
Links
- 208000028389 Nerve injury Diseases 0.000 title 1
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
- 208000020339 Spinal injury Diseases 0.000 title 1
- 210000004556 brain Anatomy 0.000 title 1
- 208000029028 brain injury Diseases 0.000 title 1
- 230000008764 nerve damage Effects 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01116812 | 2001-07-10 | ||
PCT/EP2002/007323 WO2003006016A2 (fr) | 2001-07-10 | 2002-07-03 | Utilisation d'antagonistes du recepteur nk-1 pour le traitement des lesions cerebrales, medullaires ou nerveuses |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1068266A1 true HK1068266A1 (en) | 2005-04-29 |
Family
ID=8178001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05100430A HK1068266A1 (en) | 2001-07-10 | 2005-01-17 | Use of nk-1 receptor antagonists for the treatmentof brain, spinal or nerve injury |
Country Status (24)
Country | Link |
---|---|
US (3) | US20030083345A1 (fr) |
EP (2) | EP1621195A3 (fr) |
JP (1) | JP2004536119A (fr) |
KR (1) | KR100589106B1 (fr) |
CN (1) | CN100346789C (fr) |
AR (1) | AR037008A1 (fr) |
AU (1) | AU2002328837B2 (fr) |
BR (1) | BR0210893A (fr) |
CA (1) | CA2451566C (fr) |
GT (1) | GT200200143A (fr) |
HK (1) | HK1068266A1 (fr) |
HR (1) | HRP20031071A2 (fr) |
HU (1) | HUP0401210A3 (fr) |
IL (1) | IL159350A0 (fr) |
MX (1) | MXPA04000278A (fr) |
NO (1) | NO332847B1 (fr) |
NZ (1) | NZ530107A (fr) |
PA (1) | PA8549901A1 (fr) |
PE (1) | PE20030238A1 (fr) |
PL (1) | PL211246B1 (fr) |
RU (1) | RU2304435C2 (fr) |
UY (1) | UY27374A1 (fr) |
WO (1) | WO2003006016A2 (fr) |
ZA (1) | ZA200400138B (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1303490T3 (da) * | 2000-07-14 | 2008-08-25 | Hoffmann La Roche | N-oxider som NK1-receptorantagoniskprodugs af 4-phenyl-pyridinderivater |
DK1643998T3 (da) | 2003-07-03 | 2007-12-27 | Hoffmann La Roche | NK1/NK3-antagonister til behandling af skizofreni |
GB0410215D0 (en) * | 2004-05-07 | 2004-06-09 | Lescroart Pol | Nerve damage |
MX2007000198A (es) | 2004-07-06 | 2007-03-15 | Hoffmann La Roche | Proceso para la preparacion de derivados de carboxamida-piridina utilizados como intermediarios en la sintesis de antagonistas del receptor nk-1. |
US20060030600A1 (en) * | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
EP1856052B1 (fr) * | 2005-02-22 | 2009-09-02 | F.Hoffmann-La Roche Ag | Antagonistes de nk1 |
EP2281556A1 (fr) | 2005-02-25 | 2011-02-09 | F. Hoffmann-La Roche AG | Comprimés avec une meilleure dispersibilité de substance des médicaments |
DK1863767T3 (da) * | 2005-03-23 | 2009-05-04 | Hoffmann La Roche | Metabolitter til NK-I-antagonister til emesis |
KR20150041174A (ko) | 2005-11-08 | 2015-04-15 | 버텍스 파마슈티칼스 인코포레이티드 | Atp 결합 카세트 수송체의 헤테로사이클릭 조정제 |
US7671221B2 (en) | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
US7754739B2 (en) | 2007-05-09 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
AU2008251504B2 (en) | 2007-05-09 | 2013-07-18 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
AU2008278273A1 (en) * | 2007-07-19 | 2009-01-22 | Adelaide Research & Innovation Pty Ltd | Method for reducing intracranial pressure |
DK2639224T3 (en) | 2007-12-07 | 2016-10-17 | Vertex Pharma | A process for the preparation of cycloalkylcarboxiamido-pyridinbenzoesyrer |
EP3170818B1 (fr) | 2007-12-07 | 2020-02-19 | Vertex Pharmaceuticals Incorporated | Formes solides d'acide benzoïque 3-(6- (1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) |
WO2009108657A2 (fr) | 2008-02-28 | 2009-09-03 | Vertex Pharmaceuticals Incorporated | Dérivés hétéroaryles convenant comme modulateurs du cftr |
GB0808747D0 (en) * | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
HUE056525T2 (hu) | 2010-04-07 | 2022-02-28 | Vertex Pharma | 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)ciklopropánkarboxamido)-3-metilpiridin-2-il)benzoesav gyógyszerészeti készítményei és azok adagolása |
CA2914515C (fr) | 2013-07-02 | 2018-12-11 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Procede de prevention et/ou de traitement de l'encephalopathie traumatique chronique-i |
EP3016657B1 (fr) * | 2013-07-02 | 2019-06-26 | Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro) | Procédé pour la prévention et/ou le traitement de l'encéphalopathie traumatique chronique-ii |
US20160129007A1 (en) * | 2013-07-02 | 2016-05-12 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Method for Preventing and/or Treating Chronic Traumatic Encephalopathy - IV |
WO2015068744A1 (fr) | 2013-11-08 | 2015-05-14 | キッセイ薬品工業株式会社 | Dérivé de carboxyméthylpipéridine |
US10231932B2 (en) | 2013-11-12 | 2019-03-19 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
DK3221692T3 (da) | 2014-11-18 | 2021-08-23 | Vertex Pharma | Fremgangsmåde til udførsel af tests med høj kapacitet ved hjælp af højtryksvæskekromatografi |
CA3089662A1 (fr) * | 2018-02-02 | 2019-08-08 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Formulations parenterales et leurs utilisations |
KR101970099B1 (ko) * | 2018-02-07 | 2019-04-17 | 한국과학기술연구원 | 척수 손상의 예방 및 치료용 조성물 |
KR102005019B1 (ko) * | 2018-04-04 | 2019-07-31 | 한국과학기술연구원 | 뇌졸중의 예방 및 치료용 조성물 |
EP4017589A4 (fr) * | 2019-08-23 | 2023-09-20 | Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro) | Méthodes thérapeutiques et utilisations associées |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4745123A (en) * | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
IL111002A (en) * | 1993-09-22 | 1998-09-24 | Glaxo Group Ltd | History of piperidine, their preparation and the pharmaceutical preparations containing them |
US6175013B1 (en) * | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
US5607947A (en) * | 1995-02-21 | 1997-03-04 | Eli Lilly And Company | Pyrrolidinyl tachykinin receptor antagonists |
IL116249A (en) * | 1994-12-12 | 2003-07-06 | Pfizer | Nk-1 receptor antagonists for the treatment of neuronal damage and stroke |
TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
US6214846B1 (en) * | 1997-06-27 | 2001-04-10 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
US5972938A (en) * | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
DK1394150T3 (da) * | 1999-02-24 | 2011-03-21 | Hoffmann La Roche | 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister |
BR0008494A (pt) * | 1999-02-24 | 2002-02-05 | Hoffmann La Roche | Derivados de 3-fenilpiridina e seu uso como antagonista do receptor de nk-1 |
GB9923748D0 (en) * | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
ES2208205T3 (es) * | 1999-11-29 | 2004-06-16 | F. Hoffmann-La Roche Ag | 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il-4-otolil-piridin-3-il)-isobutiramida. |
US6303790B1 (en) * | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
AUPQ514600A0 (en) * | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
-
2002
- 2002-07-02 US US10/187,587 patent/US20030083345A1/en not_active Abandoned
- 2002-07-03 WO PCT/EP2002/007323 patent/WO2003006016A2/fr active IP Right Grant
- 2002-07-03 KR KR1020047000395A patent/KR100589106B1/ko active IP Right Grant
- 2002-07-03 HU HU0401210A patent/HUP0401210A3/hu unknown
- 2002-07-03 AU AU2002328837A patent/AU2002328837B2/en not_active Expired
- 2002-07-03 CA CA2451566A patent/CA2451566C/fr not_active Expired - Lifetime
- 2002-07-03 MX MXPA04000278A patent/MXPA04000278A/es active IP Right Grant
- 2002-07-03 EP EP05017203A patent/EP1621195A3/fr not_active Withdrawn
- 2002-07-03 IL IL15935002A patent/IL159350A0/xx unknown
- 2002-07-03 CN CNB028135423A patent/CN100346789C/zh not_active Expired - Lifetime
- 2002-07-03 PL PL369535A patent/PL211246B1/pl unknown
- 2002-07-03 EP EP02764617A patent/EP1406618A2/fr not_active Withdrawn
- 2002-07-03 JP JP2003511822A patent/JP2004536119A/ja active Pending
- 2002-07-03 NZ NZ530107A patent/NZ530107A/en unknown
- 2002-07-03 BR BR0210893-3A patent/BR0210893A/pt not_active IP Right Cessation
- 2002-07-03 RU RU2004102397/15A patent/RU2304435C2/ru active
- 2002-07-05 PA PA20028549901A patent/PA8549901A1/es unknown
- 2002-07-08 PE PE2002000610A patent/PE20030238A1/es not_active Application Discontinuation
- 2002-07-08 AR ARP020102546A patent/AR037008A1/es unknown
- 2002-07-09 UY UY27374A patent/UY27374A1/es not_active Application Discontinuation
- 2002-07-09 GT GT200200143A patent/GT200200143A/es unknown
-
2003
- 2003-12-22 HR HR20031071A patent/HRP20031071A2/xx not_active Application Discontinuation
-
2004
- 2004-01-07 NO NO20040057A patent/NO332847B1/no not_active IP Right Cessation
- 2004-01-08 ZA ZA2004/00138A patent/ZA200400138B/en unknown
-
2005
- 2005-01-17 HK HK05100430A patent/HK1068266A1/xx not_active IP Right Cessation
-
2006
- 2006-07-05 US US11/481,216 patent/US20060247240A1/en not_active Abandoned
-
2010
- 2010-09-21 US US12/886,691 patent/US20110053954A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1068266A1 (en) | Use of nk-1 receptor antagonists for the treatmentof brain, spinal or nerve injury | |
HRP20020593A2 (en) | Brain, spinal and nerve injury treatment | |
HK1066534A1 (en) | Urea-compounds active as vanilloid receptor antagonists for the treatment of pain | |
PL363907A1 (en) | Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain. | |
AU2003249983A8 (en) | Piperidines useful for the treatment of central nervous system disorders | |
EP1434801A4 (fr) | Traitement pour des troubles du systeme nerveux central | |
EP1420854A4 (fr) | Traitement de troubles neuropsychiatriques par stimulation nerveuse a proximite du diaphragme | |
IL176581A0 (en) | Immunomodulatory compounds for the treatment of central nervous system disorders | |
HK1152243A1 (en) | Vegf for use in the treatment of central nervous system disorders vegf | |
EP1399160A4 (fr) | Antagonistes du recepteur nr2b pour le traitement ou la prevention de migraines | |
MXPA03009644A (es) | Grupos azabiciclicos sustituidos para el tratamiento de enfermedades. | |
IL147977A0 (en) | Substituted 1,5-dihydropyrrol-2-on derivatives as nmda receptor antagonists for the treatment of pain | |
PL368556A1 (en) | Methods for treating or preventing skin disorders using cd2-binding agents | |
ZA200402514B (en) | 4[Piperidin-4-yliden-(3-carbamoylphenyl)methyl]benzamide derivatives and their use for the treatment of pain, spinal injuries or gastrointestinal disorders. | |
AU2003290059A8 (en) | Use of cd137 antagonists for the treatment of tumors | |
IL157145A0 (en) | Use of dc23 antagonists for the treatment of neoplastic disorders | |
IL162475A0 (en) | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists | |
ZA200509169B (en) | Method of treating or preventing central nervous system disorders with compounds having selectivity for the alpha 3 subunit of the benzodiazepine receptor | |
IL162053A0 (en) | Method for the treatment of bone disorders | |
WO2004048318A8 (fr) | Procede ameliore pour la preparation d'indenes 1,3-substitutees | |
HK1040933A1 (zh) | N-取代的氮雜二環烷衍生物在治療中樞神經系統疾病中的應用 | |
AU2003245995A8 (en) | Use of gaba-c receptor antagonists for the treatment of myopia | |
TW390191U (en) | Examining device for nerves of the spinal cord | |
PL374077A1 (en) | Use of 5-ht2 receptor antagonists for the treatment of sleep disorders | |
SI1200402T1 (sl) | Substituirani 1,5-dihidropirol-2-on-derivati, ucinkoviti kot antagonisti NMDA-receptorja za tretiranje bolecinskih stanj |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110703 |