HK1061566A1 - Proteins producing an altered immunogenic response and methods of making and using the same - Google Patents

Proteins producing an altered immunogenic response and methods of making and using the same

Info

Publication number
HK1061566A1
HK1061566A1 HK04104503.8A HK04104503A HK1061566A1 HK 1061566 A1 HK1061566 A1 HK 1061566A1 HK 04104503 A HK04104503 A HK 04104503A HK 1061566 A1 HK1061566 A1 HK 1061566A1
Authority
HK
Hong Kong
Prior art keywords
methods
making
same
immunogenic response
altered immunogenic
Prior art date
Application number
HK04104503.8A
Other languages
English (en)
Inventor
David A Estell
Grant C Ganshaw
Fiona A Harding
Edmund A Larenas
Ayrookaran J Poulose
Elizabeth Ellen Sikorski
Russell Philip Elliott
Original Assignee
Danisco Us Inc
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Procter & Gamble filed Critical Danisco Us Inc
Publication of HK1061566A1 publication Critical patent/HK1061566A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK04104503.8A 2001-03-23 2004-06-23 Proteins producing an altered immunogenic response and methods of making and using the same HK1061566A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27845901P 2001-03-23 2001-03-23
PCT/US2002/009205 WO2002077187A2 (en) 2001-03-23 2002-03-22 Proteins producing an altered immunogenic response and methods of making and using the same

Publications (1)

Publication Number Publication Date
HK1061566A1 true HK1061566A1 (en) 2004-09-24

Family

ID=23065053

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04104503.8A HK1061566A1 (en) 2001-03-23 2004-06-23 Proteins producing an altered immunogenic response and methods of making and using the same

Country Status (11)

Country Link
US (3) US6929939B2 (xx)
EP (1) EP1373296B1 (xx)
CN (1) CN100489094C (xx)
AT (1) ATE527276T1 (xx)
AU (1) AU2002254374A1 (xx)
CA (1) CA2441595C (xx)
DK (1) DK1373296T3 (xx)
HK (1) HK1061566A1 (xx)
PL (1) PL210859B1 (xx)
RU (1) RU2311458C2 (xx)
WO (1) WO2002077187A2 (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
ES2368718T3 (es) * 1997-10-23 2011-11-21 Danisco Us Inc. Variantes de subtilisina con múltiples sustituciones.
US6929939B2 (en) * 2001-03-23 2005-08-16 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US20030157645A1 (en) * 2001-12-21 2003-08-21 Direvo Bio Tech Ag. Subtilisin variants with improved characteristics
EP1461072A4 (en) * 2001-12-31 2005-02-09 Genencor Int PROTEASES PRODUCING MODIFIED IMMUNOLOGICAL RESPONSE AND METHODS OF PRODUCTION AND USE
JP5328002B2 (ja) * 2002-01-16 2013-10-30 ジェネンコー・インターナショナル・インク 複数置換プロテアーゼ変異体
DK1523553T3 (da) * 2002-01-16 2010-04-19 Genencor Int Multi-substituerede proteasevarianter
WO2004024187A2 (en) * 2002-09-13 2004-03-25 Zicam, Llc. Compositions to reduce congestion and methods for application thereof to the nasal membrane
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US7202202B2 (en) * 2003-06-27 2007-04-10 The Procter & Gamble Company Consumable detergent composition for use in a lipophilic fluid
CA2534629C (en) * 2003-08-06 2016-01-19 University Of Maryland Biotechnology Institute Engineered proteases for affinity purification and processing of fusion proteins
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
WO2005044838A2 (en) * 2003-11-03 2005-05-19 Genencor International, Inc. Cd4+ epitopes of bone morphogenetic proteins
EP1697741A4 (en) 2003-12-04 2008-02-13 Xencor Inc PROCESS FOR PRODUCING PROTEIN VARIANTS WITH INCREASED HOST STRUCTURE CONTENT AND COMPOSITIONS THEREOF
DE602004025506D1 (de) * 2003-12-18 2010-03-25 Genencor Int Beta-lactamase-cd4+-t-zellepitope
EP1737890A2 (en) 2004-03-24 2007-01-03 Xencor, Inc. Immunoglobulin variants outside the fc region
EP1735433B1 (en) * 2004-04-02 2010-12-08 Novozymes A/S Subtilase variants having altered immunogenicity
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
EP2940043A1 (en) 2004-07-15 2015-11-04 Xencor, Inc. Optimized fc variants
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
KR101027427B1 (ko) 2004-11-12 2011-04-11 젠코어 인코포레이티드 ＦcRn에 대하여 증가된 결합력을 갖는 Ｆc 변이체
CN101151275B (zh) * 2005-04-27 2013-07-10 金克克国际有限公司 用于降低细胞因子免疫原性和去除细胞表面标记的方法
AU2006261443A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Proteases for pharmaceutical use
CA2624189A1 (en) 2005-10-03 2007-04-12 Xencor, Inc. Fc variants with optimized fc receptor binding properties
WO2008045380A2 (en) * 2006-10-04 2008-04-17 Codon Devices, Inc. Nucleic acid libraries and their design and assembly
AU2008345242B2 (en) 2007-10-31 2014-02-27 Xencor, Inc. Fc variants with altered binding to FcRn
US20110160071A1 (en) * 2008-06-03 2011-06-30 Baynes Brian M Novel Proteins and Methods for Designing the Same
US20110251073A1 (en) * 2008-06-06 2011-10-13 Cascao-Pereira Luis G Compositions And Methods Comprising Variant Microbial Proteases
MX2011008159A (es) * 2009-02-02 2011-11-18 Procter & Gamble Composicion detergente liquida para el lavado manual de vajillas.
EP2216391A1 (en) * 2009-02-02 2010-08-11 The Procter & Gamble Company Liquid hand dishwashing detergent composition
ES2461892T3 (es) * 2009-02-02 2014-05-21 The Procter & Gamble Company Composición detergente líquida para lavado de vajillas a mano
EP3023483A1 (en) * 2009-02-02 2016-05-25 The Procter and Gamble Company Liquid hand diswashing detergent composition
EP2216392B1 (en) * 2009-02-02 2013-11-13 The Procter and Gamble Company Liquid hand dishwashing detergent composition
EP2216390B1 (en) * 2009-02-02 2013-11-27 The Procter and Gamble Company Hand dishwashing method
CN102388132A (zh) * 2009-04-01 2012-03-21 丹尼斯科美国公司 包含α淀粉酶和蛋白酶的清洁***
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
US8728790B2 (en) * 2009-12-09 2014-05-20 Danisco Us Inc. Compositions and methods comprising protease variants
EP2558573B1 (en) * 2010-04-15 2017-02-22 Danisco US Inc. Compositions and methods comprising variant proteases
HUE034524T2 (en) * 2010-05-06 2018-02-28 Procter & Gamble Consumer articles with protease variants
DE102010063458A1 (de) * 2010-12-17 2012-06-21 Henkel Ag & Co. Kgaa Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Amylase
US9039689B2 (en) 2011-05-11 2015-05-26 Icecure Medical Ltd. Phase separation of cryogen in cryosurgical instrument
EP2793944A4 (en) 2011-12-23 2015-09-02 Nicholas B Lydon IMMUNOGLOBULINS AND VARIANTS DIRECTED AGAINST PATHOGENIC MICROBES
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
GB201212934D0 (en) * 2012-07-20 2012-09-05 Dupont Nutrition Biosci Aps Method

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34606A (en) * 1862-03-04 Improvement in machines for combing cotton
US3755560A (en) * 1971-06-30 1973-08-28 Dow Chemical Co Nongreasy cosmetic lotions
US3929678A (en) * 1974-08-01 1975-12-30 Procter & Gamble Detergent composition having enhanced particulate soil removal performance
JPS5333919A (en) * 1976-09-10 1978-03-30 Nippon Steel Corp Production of cold rolled aluminum killed steel sheet with excellent deep drawability
JPS51125468A (en) * 1975-03-27 1976-11-01 Sanyo Chem Ind Ltd Method of preparing resins of high water absorbency
US4152416A (en) 1976-09-17 1979-05-01 Marra Dorothea C Aerosol antiperspirant compositions delivering astringent salt with low mistiness and dustiness
NL190101C (nl) * 1978-11-13 1993-11-01 Givaudan & Cie Sa Dibenzoylmethaanverbinding en tegen licht beschermend preparaat.
US4261868A (en) * 1979-08-08 1981-04-14 Lever Brothers Company Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound
US4404128A (en) * 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
US4421769A (en) * 1981-09-29 1983-12-20 The Procter & Gamble Company Skin conditioning composition
JPS58144105A (ja) 1982-02-12 1983-08-27 Kurabo Ind Ltd スケ−ル除去獣毛繊維の製法
IE81141B1 (en) 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5185258A (en) * 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
US5204015A (en) * 1984-05-29 1993-04-20 Genencor International, Inc. Subtilisin mutants
US5264366A (en) 1984-05-29 1993-11-23 Genencor, Inc. Protease deficient bacillus
US4663157A (en) * 1985-02-28 1987-05-05 The Proctor & Gamble Company Sunscreen compositions
DE3666914D1 (en) * 1985-07-10 1989-12-21 Ciba Geigy Ag Cleaning set for contact lenses
US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
SG30639G (en) 1986-04-30 1995-09-01 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
US4937370A (en) * 1987-06-02 1990-06-26 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
EP0496433B1 (en) * 1987-10-22 1999-03-24 The Procter & Gamble Company Photoprotection compositions comprising chelating agents
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
US5116741A (en) * 1988-04-12 1992-05-26 Genex Corporation Biosynthetic uses of thermostable proteases
US5087372A (en) * 1989-03-24 1992-02-11 Asahi Kasei Kogyo Kabushiki Kaisha Method for removing heavy metal ions from contaminated water and a porous membrane usable therefor
AU618675B2 (en) * 1989-05-17 1992-01-02 Amgen, Inc. Multiply mutated subtilisins
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
US5011681A (en) 1989-10-11 1991-04-30 Richardson-Vicks, Inc. Facial cleansing compositions
US5264365A (en) * 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
US5073371A (en) * 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
US5073372A (en) 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
CA2095852C (en) * 1990-12-05 2001-05-08 Uffe Lovborg Proteins with changed epitopes and methods for the production thereof
DK132892D0 (da) 1992-10-30 1992-10-30 Novo Nordisk As Proteiner
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
CN1082999C (zh) * 1993-10-14 2002-04-17 普罗格特-甘布尔公司 含蛋白酶的洗涤组合物
AU1253695A (en) * 1993-10-14 1995-05-04 Procter & Gamble Company, The Bleaching compositions comprising protease enzymes
FR2712286B1 (fr) * 1993-11-12 1995-12-22 Oreal Nouveaux N-mercaptoalkyl alcanediamines et leur utilisation.
US6068834A (en) 1994-03-04 2000-05-30 The Procter & Gamble Company Skin lightening compositions
FR2719481B1 (fr) 1994-05-05 1996-05-31 Oreal Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux.
CA2192665C (en) 1994-06-15 2001-12-18 Greg George Hillebrand Methods of lightening hyperpigmented regions in mammalian skin
GB9415421D0 (en) 1994-07-30 1994-09-21 Procter & Gamble Cosmetic compositions and processes for manufacture thereof
AU709850B2 (en) 1994-11-28 1999-09-09 Procter & Gamble Company, The Topical skin care compositions containing thickened polyol carboxylic acid esters as skin conditioning agents
WO1996017929A1 (en) 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide with reduced allergenicity
AU5893696A (en) 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
CN1273589C (zh) 1996-02-15 2006-09-06 诺沃奇梅兹有限公司 多肽缀合
US5627508A (en) * 1996-05-10 1997-05-06 The United States Of America As Represented By The Secretary Of The Navy Pilot vehicle which is useful for monitoring hazardous conditions on railroad tracks
US5827508A (en) 1996-09-27 1998-10-27 The Procter & Gamble Company Stable photoprotective compositions
AU734338B2 (en) 1996-11-22 2001-06-14 Procter & Gamble Company, The Cosmetic compositions
US5966485A (en) * 1996-11-22 1999-10-12 Siecor Corporation Method of producing core protrusion relative to cladding in an optical fiber of a fiber optic connector
MA25044A1 (fr) * 1997-10-23 2000-10-01 Procter & Gamble Compositions de lavage contenant des variants de proteases multisubstituees.
CA2325568A1 (en) 1998-03-26 1999-09-30 The Procter & Gamble Company Serine protease variants having amino acid substitutions
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US5989528A (en) 1998-07-30 1999-11-23 The Procter & Gamble Company Sunscreen compositions
US5935556A (en) 1998-07-30 1999-08-10 The Procter & Gamble Company Sunscreen compositions
US5972316A (en) * 1998-10-16 1999-10-26 The Procter & Gamble Company UV protection compositions
US5968485A (en) 1998-10-16 1999-10-19 The Procter & Gamble Company UV protection compositions
AU1275599A (en) 1998-10-23 2000-05-15 Procter & Gamble Company, The Skin care compositions
JP2003505070A (ja) * 1999-07-22 2003-02-12 ザ、プロクター、エンド、ギャンブル、カンパニー 定められたエピトープ領域においてアミノ酸置換を有するサブチリシンプロテアーゼ変異体
US6428799B1 (en) * 1999-08-02 2002-08-06 The Procter & Gamble Company Personal care articles
WO2001057578A1 (de) 2000-01-31 2001-08-09 Sercalo Microtechnology Ltd. Schalteranordnung für strahlungsleiter
US20030170846A1 (en) * 2000-04-24 2003-09-11 Weisgerber David John Enzyme variants having one or more D-amino acid substitutions
DE60144399D1 (de) 2000-10-02 2011-05-19 Danisco Us Inc Methode zur bestimmung der immunogenität von proteinen, die eine veränderte immunantwort hervorrufen
US6929939B2 (en) * 2001-03-23 2005-08-16 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same

Also Published As

Publication number Publication date
RU2311458C2 (ru) 2007-11-27
AU2002254374A1 (en) 2002-10-08
CN1512998A (zh) 2004-07-14
PL210859B1 (pl) 2012-03-30
CA2441595C (en) 2012-07-03
DK1373296T3 (da) 2012-01-09
US20030118605A1 (en) 2003-06-26
US6929939B2 (en) 2005-08-16
US20050202551A1 (en) 2005-09-15
CN100489094C (zh) 2009-05-20
US7476528B2 (en) 2009-01-13
WO2002077187A3 (en) 2003-04-24
EP1373296A4 (en) 2007-03-28
US20050202552A1 (en) 2005-09-15
EP1373296B1 (en) 2011-10-05
EP1373296A2 (en) 2004-01-02
CA2441595A1 (en) 2002-10-03
ATE527276T1 (de) 2011-10-15
WO2002077187A2 (en) 2002-10-03
PL364138A1 (en) 2004-12-13
RU2003131177A (ru) 2005-01-20

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