HK1014952A1 - 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity. - Google Patents

4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity.

Info

Publication number
HK1014952A1
HK1014952A1 HK99100183A HK99100183A HK1014952A1 HK 1014952 A1 HK1014952 A1 HK 1014952A1 HK 99100183 A HK99100183 A HK 99100183A HK 99100183 A HK99100183 A HK 99100183A HK 1014952 A1 HK1014952 A1 HK 1014952A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
aryl
tetrahydropyridines
phenylalkyl
neurotrophic
Prior art date
Application number
HK99100183A
Other languages
English (en)
Inventor
Domenico Badone
Marco Baroni
Rosanna Cardamone
Jacqueline Fournier
Umberto Guzzi
Alessandra Ielmini
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of HK1014952A1 publication Critical patent/HK1014952A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
HK99100183A 1995-06-28 1999-01-14 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity. HK1014952A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9507760A FR2736053B1 (fr) 1995-06-28 1995-06-28 Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
PCT/FR1996/000995 WO1997001536A1 (fr) 1995-06-28 1996-06-26 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice

Publications (1)

Publication Number Publication Date
HK1014952A1 true HK1014952A1 (en) 1999-10-08

Family

ID=9480466

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99100183A HK1014952A1 (en) 1995-06-28 1999-01-14 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity.

Country Status (30)

Country Link
US (1) US5981754A (xx)
EP (2) EP0837848B1 (xx)
JP (2) JP3147906B2 (xx)
KR (1) KR100460581B1 (xx)
CN (1) CN1153765C (xx)
AT (1) ATE223897T1 (xx)
AU (1) AU715090B2 (xx)
BR (1) BR9608662A (xx)
CA (1) CA2225746C (xx)
CY (1) CY2312B1 (xx)
CZ (1) CZ291075B6 (xx)
DE (1) DE69623631T2 (xx)
DK (1) DK0837848T3 (xx)
EE (1) EE03870B1 (xx)
ES (1) ES2183965T3 (xx)
FR (1) FR2736053B1 (xx)
HK (1) HK1014952A1 (xx)
HU (1) HUP9900055A3 (xx)
IL (1) IL122159A (xx)
IS (1) IS1999B (xx)
NO (1) NO310144B1 (xx)
NZ (1) NZ312723A (xx)
PL (2) PL192353B1 (xx)
PT (1) PT837848E (xx)
RU (1) RU2163237C2 (xx)
SK (2) SK285433B6 (xx)
TR (1) TR199701710T1 (xx)
UA (1) UA62914C2 (xx)
WO (1) WO1997001536A1 (xx)
ZA (1) ZA965527B (xx)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762514B1 (fr) * 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771006B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
AU4685699A (en) * 1998-06-19 2000-01-05 Eli Lilly And Company Preparation of heteroaryl compounds
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
WO2002085888A1 (fr) * 2001-04-20 2002-10-31 Sanofi-Synthelabo Tetrahydropyridyl-alkyl-heterocycles, procede pour leur preparation et compositions pharmaceutiques les contenants
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US7683069B2 (en) * 2002-12-16 2010-03-23 Mitsubishi Tanabe Pharma Corporation 3-substituted-4-pyrimidone derivatives
EP2426120A1 (en) 2003-08-18 2012-03-07 Fujifilm Finechemicals Co., Ltd. Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
CA2589565A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
EP1768954A4 (en) * 2004-06-24 2008-05-28 Incyte Corp 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS
AU2005258248A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
NZ551603A (en) * 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
BRPI0512630A (pt) * 2004-06-24 2008-03-25 Incyte Corp compostos de amido e seu uso como produtos farmacêuticos
EP1778229A4 (en) * 2004-08-10 2009-06-17 Incyte Corp AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS
WO2006053024A2 (en) * 2004-11-10 2006-05-18 Incyte Corporation Lactam compounds and their use as pharmaceuticals
US8110581B2 (en) * 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
KR20070097441A (ko) * 2004-11-18 2007-10-04 인사이트 산 디에고 인코포레이티드 11-β 하이드록실 스테로이드 데하이드로게나제 유형 1의억제제 및 이를 사용하는 방법
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
JP4864342B2 (ja) * 2005-04-27 2012-02-01 北興化学工業株式会社 ビアリール化合物の製造方法
JP2009508963A (ja) * 2005-09-21 2009-03-05 インサイト・コーポレイション アミド化合物および医薬組成物としてのその使用
EP1957494A2 (en) * 2005-12-05 2008-08-20 Incyte Corporation Lactam compounds and methods of using the same
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
AU2007210018A1 (en) * 2006-01-31 2007-08-09 Incyte Corporation Amido compounds and their use as pharmaceuticals
US20070213311A1 (en) * 2006-03-02 2007-09-13 Yun-Long Li Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070293529A1 (en) * 2006-05-01 2007-12-20 Yun-Long Li Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1
CA2652375A1 (en) * 2006-05-17 2007-11-29 Incyte Corporation Heterocyclic inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type i and methods of using the same
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
EP2526081B1 (de) * 2010-01-19 2015-07-01 Bayer Intellectual Property GmbH Verfahren zur herstellung von aryl- und heteroarylessigsäure-derivaten
WO2018195649A1 (en) * 2017-04-26 2018-11-01 Alberta Research Chemicals Inc. Substituted tetrahydropyridine derivatives as ido-1 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CZ422297A3 (cs) 1998-04-15
JP2001114763A (ja) 2001-04-24
PL324216A1 (en) 1998-05-11
IS1999B (is) 2005-04-15
NO310144B1 (no) 2001-05-28
EE9700348A (et) 1998-06-15
RU2163237C2 (ru) 2001-02-20
SK178197A3 (en) 1998-07-08
DE69623631D1 (en) 2002-10-17
CA2225746C (en) 2004-05-18
UA62914C2 (en) 2004-01-15
JPH11506118A (ja) 1999-06-02
HUP9900055A2 (hu) 1999-04-28
ATE223897T1 (de) 2002-09-15
CY2312B1 (en) 2003-11-14
BR9608662A (pt) 1999-05-04
JP3147906B2 (ja) 2001-03-19
SK285433B6 (sk) 2007-01-04
WO1997001536A1 (fr) 1997-01-16
US5981754A (en) 1999-11-09
JP3302351B2 (ja) 2002-07-15
NZ312723A (en) 1999-10-28
DK0837848T3 (da) 2003-01-06
DE69623631T2 (de) 2003-08-07
KR100460581B1 (ko) 2005-04-14
EP1216996A2 (fr) 2002-06-26
FR2736053B1 (fr) 1997-09-19
CN1189154A (zh) 1998-07-29
SK283707B6 (sk) 2003-12-02
KR19990028431A (ko) 1999-04-15
NO976079L (no) 1997-12-23
CA2225746A1 (en) 1997-01-16
EE03870B1 (et) 2002-10-15
MX9710472A (es) 1998-03-31
EP0837848A1 (fr) 1998-04-29
ZA965527B (en) 1997-01-24
IS4641A (is) 1997-12-23
EP1216996A3 (fr) 2003-10-15
ES2183965T3 (es) 2003-04-01
CZ291075B6 (cs) 2002-12-11
AU715090B2 (en) 2000-01-13
PT837848E (pt) 2002-12-31
AU6461996A (en) 1997-01-30
TR199701710T1 (xx) 1998-05-21
IL122159A (en) 2001-06-14
NO976079D0 (no) 1997-12-23
PL192353B1 (pl) 2006-10-31
IL122159A0 (en) 1998-04-05
HUP9900055A3 (en) 1999-11-29
FR2736053A1 (fr) 1997-01-03
EP0837848B1 (fr) 2002-09-11
PL187087B1 (pl) 2004-05-31
CN1153765C (zh) 2004-06-16

Similar Documents

Publication Publication Date Title
CY2312B1 (en) 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity.
AU8680791A (en) Synergistic ultraviolet absorber compositions containing hydroxy aryl triazines and tetraalkyl piperidines
MX9701679A (es) Derivados de piperidina como antagonistas de la neuroquinina.
ATE226813T1 (de) Zusammensetzungen enthaltend ein dibenzoylmethanderivat, ein 1,3,5-triazinderivat und eine amid-verbindung sowie ihre verwendung
HUT49864A (en) Process for producing new square brackets open (aminomethyl)-oxooxazolidinyl square brackets closed -aroyl or arylmethylbenzene derivatives and pharmaceutical compositions comprising same
HUP9802985A3 (en) 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives, pharmaceutical compositions containing them and process for producing them
AU3443595A (en) Benzylpiperidine derivatives
IL102833A0 (en) Azacyclic compounds,their preparation and pharmaceutical compositions containing them
IL115572A0 (en) Novel substituted 4-(azanaphthoylamino)-piperidines salts of these and pharmaceutical compositions containing them
HUT63384A (en) Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
HUT75053A (en) Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines, insecticid composition and use of it
TW341570B (en) Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof
DE69209701D1 (de) Herstellung substituierter Tetrahydropyridine
UA41928C2 (uk) Похідні оксазолідину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання, спосіб лікування захворювань
HU9503592D0 (en) Use of 5-acyl-1,4-dihydropyridines
CA2275353A1 (en) 1-phenylalkyl-1,2,3,6-tetrahydropyridines for treating alzheimer's disease
RU99115083A (ru) 1-фенилалкил-1,2,3,6-тетрагидропиридины для лечения болезни альцгеймера
IL112282A (en) Preparation of chloropyridines and certain novel chloropyridinium chlorides used therefor
PL336894A1 (en) Salts of derivatives of optically active sulphoxides

Legal Events

Date Code Title Description
CHPA Change of a particular in the register (except of change of ownership)
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080626