UA41928C2 - Похідні оксазолідину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання, спосіб лікування захворювань - Google Patents
Похідні оксазолідину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання, спосіб лікування захворюваньInfo
- Publication number
- UA41928C2 UA41928C2 UA95114761A UA95114761A UA41928C2 UA 41928 C2 UA41928 C2 UA 41928C2 UA 95114761 A UA95114761 A UA 95114761A UA 95114761 A UA95114761 A UA 95114761A UA 41928 C2 UA41928 C2 UA 41928C2
- Authority
- UA
- Ukraine
- Prior art keywords
- preparation
- oxazolidine
- derivatives
- diseases
- treatment
- Prior art date
Links
- 150000002917 oxazolidines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Похідні оксазолідину формули (I): де Х означає О, S, NH або NA Y означає заміщений за допомогою R2 азирідиновий, азетидіновий, піролідиновий, піперидиновий, гексагідроазеіновий або піперазиновий залишок R1 означає R2 означає -CrH2r-COOR3, R3 означає Н, А або Аr, А означає алкіл з 1-6 C атомами, В означає Н, А, циклоалкіл з 3-7 C атомами, Аr-СkH2k або амідино-групу, Аr означає незаміщений або одно- або дворазово заміщений за допомогою А, Сl, Вr, I, NO2, CN, ОА, ОН, NH2, NHA і/або NA2 фенильний або бензильний залишок, "k" означає 1, 2, 3 або 4, "m" і "r" кожен, незалежно один від одного, означають 0,1, 2, 3 або 4, і "n" означає 2, 3 або 4, а також їх фізіологічно прийнятні солі.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4439846A DE4439846A1 (de) | 1994-11-08 | 1994-11-08 | Adhäsionsrezeptor-Antagonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
UA41928C2 true UA41928C2 (uk) | 2001-10-15 |
Family
ID=6532768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA95114761A UA41928C2 (uk) | 1994-11-08 | 1995-11-01 | Похідні оксазолідину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання, спосіб лікування захворювань |
Country Status (22)
Country | Link |
---|---|
US (1) | US5776937A (uk) |
EP (1) | EP0711770A1 (uk) |
JP (1) | JPH08208629A (uk) |
KR (1) | KR100384978B1 (uk) |
CN (1) | CN1069640C (uk) |
AR (1) | AR002245A1 (uk) |
AU (1) | AU704184B2 (uk) |
BR (1) | BR9505109A (uk) |
CA (1) | CA2162223A1 (uk) |
CO (1) | CO4520229A1 (uk) |
CZ (1) | CZ291049B6 (uk) |
DE (1) | DE4439846A1 (uk) |
FI (1) | FI955351A (uk) |
HU (1) | HU217085B (uk) |
NO (1) | NO306113B1 (uk) |
PL (1) | PL183595B1 (uk) |
RU (1) | RU2155762C2 (uk) |
SK (1) | SK281815B6 (uk) |
TR (1) | TR199501389A2 (uk) |
TW (1) | TW316903B (uk) |
UA (1) | UA41928C2 (uk) |
ZA (1) | ZA959434B (uk) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0710657B1 (de) * | 1994-11-02 | 1998-08-26 | MERCK PATENT GmbH | Adhäsionsrezeptor-Antagonisten |
US6046331A (en) * | 1998-12-17 | 2000-04-04 | Synaptic Pharmaceutical Corporation | Imidazolones and their use in treating benign prostatic hyperplasia and other disorders |
CN1398189A (zh) | 1998-12-23 | 2003-02-19 | G.D.西尔公司 | 用于***形成的放疗与cox-2抑制剂的联合治疗 |
AU4224699A (en) | 1999-01-27 | 2000-08-18 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
AU2003275480A1 (en) * | 2002-10-07 | 2004-05-04 | Smithkline Beecham Corporation | Compounds |
CN102796091A (zh) * | 2011-05-24 | 2012-11-28 | 北大方正集团有限公司 | 取代的噁唑烷酮化合物及其制备方法和应用 |
MA38135B1 (fr) * | 2012-10-29 | 2018-11-30 | Hoffmann La Roche | Dérivés d'oxazolidinone 3,4-disubstituée et leur utilisation comme inhibiteurs des canaux potassiques activés par le calcium |
CN104230915B (zh) * | 2014-08-29 | 2016-08-17 | 南京大学 | 含噻唑烷二酮的苯基哌嗪衍生物及其制备方法与用途 |
KR20200017496A (ko) | 2017-06-20 | 2020-02-18 | 임브리아 파마슈티칼스, 인크. | 심장 대사의 효율을 증가시키기 위한 조성물 및 방법 |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3723797A1 (de) * | 1987-07-18 | 1989-01-26 | Merck Patent Gmbh | Oxazolidinone |
US5053393A (en) * | 1988-07-20 | 1991-10-01 | Monsanto Company | Novel platelet-aggregation inhibitor |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
DE4005371A1 (de) * | 1990-02-21 | 1991-08-22 | Merck Patent Gmbh | Oxazolidinone |
DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
DE4405633A1 (de) * | 1993-05-01 | 1994-11-03 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
-
1994
- 1994-11-08 DE DE4439846A patent/DE4439846A1/de not_active Withdrawn
-
1995
- 1995-10-26 EP EP95116889A patent/EP0711770A1/de not_active Withdrawn
- 1995-11-01 UA UA95114761A patent/UA41928C2/uk unknown
- 1995-11-02 SK SK1368-95A patent/SK281815B6/sk unknown
- 1995-11-02 AU AU36618/95A patent/AU704184B2/en not_active Ceased
- 1995-11-06 CZ CZ19952888A patent/CZ291049B6/cs not_active IP Right Cessation
- 1995-11-06 CA CA002162223A patent/CA2162223A1/en not_active Abandoned
- 1995-11-06 TW TW084111748A patent/TW316903B/zh active
- 1995-11-07 BR BR9505109A patent/BR9505109A/pt not_active IP Right Cessation
- 1995-11-07 KR KR1019950040017A patent/KR100384978B1/ko not_active IP Right Cessation
- 1995-11-07 CN CN95118753A patent/CN1069640C/zh not_active Expired - Fee Related
- 1995-11-07 ZA ZA959434A patent/ZA959434B/xx unknown
- 1995-11-07 US US08/551,743 patent/US5776937A/en not_active Expired - Fee Related
- 1995-11-07 PL PL95311257A patent/PL183595B1/pl not_active IP Right Cessation
- 1995-11-07 NO NO954458A patent/NO306113B1/no not_active IP Right Cessation
- 1995-11-07 FI FI955351A patent/FI955351A/fi not_active IP Right Cessation
- 1995-11-07 HU HU9503191A patent/HU217085B/hu not_active IP Right Cessation
- 1995-11-08 CO CO95052761A patent/CO4520229A1/es unknown
- 1995-11-08 JP JP7313684A patent/JPH08208629A/ja active Pending
- 1995-11-08 AR ARP950100091A patent/AR002245A1/es unknown
- 1995-11-08 TR TR95/01389A patent/TR199501389A2/xx unknown
- 1995-11-08 RU RU95119427/04A patent/RU2155762C2/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CO4520229A1 (es) | 1997-10-15 |
HUT76052A (en) | 1997-06-30 |
DE4439846A1 (de) | 1996-05-09 |
CN1132201A (zh) | 1996-10-02 |
AU3661895A (en) | 1996-05-23 |
NO954458D0 (no) | 1995-11-07 |
CZ291049B6 (cs) | 2002-12-11 |
CN1069640C (zh) | 2001-08-15 |
JPH08208629A (ja) | 1996-08-13 |
SK281815B6 (sk) | 2001-08-06 |
AR002245A1 (es) | 1998-03-11 |
BR9505109A (pt) | 1997-09-09 |
NO954458L (no) | 1996-05-09 |
HU217085B (hu) | 1999-11-29 |
PL311257A1 (en) | 1996-05-13 |
KR100384978B1 (ko) | 2003-09-02 |
US5776937A (en) | 1998-07-07 |
PL183595B1 (pl) | 2002-06-28 |
TR199501389A2 (tr) | 1996-07-21 |
EP0711770A1 (de) | 1996-05-15 |
AU704184B2 (en) | 1999-04-15 |
SK136895A3 (en) | 1996-06-05 |
FI955351A (fi) | 1996-05-09 |
ZA959434B (en) | 1996-05-15 |
TW316903B (uk) | 1997-10-01 |
FI955351A0 (fi) | 1995-11-07 |
KR960017663A (ko) | 1996-06-17 |
HU9503191D0 (en) | 1996-01-29 |
CA2162223A1 (en) | 1996-05-09 |
CZ288895A3 (en) | 1996-06-12 |
RU2155762C2 (ru) | 2000-09-10 |
NO306113B1 (no) | 1999-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE219766T1 (de) | N-acylierte 4-aminopiperidin derivate als aktive bestandteile von peripher gefässerweiternden wikstoffen | |
DE69923849D1 (de) | Quinolin-2-on-derivate verwendbar als antikrebsmittel | |
UA41928C2 (uk) | Похідні оксазолідину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання, спосіб лікування захворювань | |
CA2121253A1 (en) | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | |
DE69420564D1 (de) | Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton | |
DK645688D0 (da) | 3-(4-(1-substitueret 4-piperazinyl)butyl)-4-thiazolidinoner, deres fremstilling og anvendelse | |
NO943093L (no) | Fremgangsmåte for fremstilling av clavulansyre | |
PT928788E (pt) | Compostos farmaceuticamente activos | |
NO20015172L (no) | 1-metyl-erytromycin-derivater | |
NO984878L (no) | Fremstilling og anvendelse som medikamenter av 3-alkoksypyridin-2-karboksylsyreamidestere | |
GB9408185D0 (en) | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | |
DZ1694A1 (fr) | "n-(2-Aminoethyl)-benzothialozones". | |
DE69828317D1 (de) | Verfahren zur Herstellung von N-((4-Phenyl)methylphenyl)piperazinen | |
IE890177L (en) | Piperidinyl derivatives | |
HUT58709A (en) | Process for producing n-aryl-piperazin-acetamide derivatives and pharmaceutical compositions containing them | |
ES2012648A6 (es) | Procedimiento para la preparacion de nuevos derivados de 1,4-benzoxazina y 1,4-benzotiazina. | |
BG101220A (en) | N-substituted 3-azabicyclo (93.2.0) heptane derivatives,their preparation and use | |
HUP0203275A2 (hu) | 1-(Gyűrűs amino)-alkilciklohexán-származékok, ezeket tartalmazó görcsoldó hatású gyógyszerkészítmények, valamint ezek alkalmazása | |
HUT70052A (en) | Process for producing pharmaceutical compositions containing pirimidone derivatives in the treatment of certain airway or skin diseases | |
DK0506434T3 (da) | Thiazolidinon- og oxazolidinon-derivater, fremstilling deraf og deres anvendelse som vasodilaterende midler | |
RU1795966C (ru) | Способ получени производных дитрет-бутиловых эфиров 3,4-оксибензоилоксипропаноламинов | |
DK0427518T3 (da) | NMDA-blokerende forbindelser, farmaceutiske præparater, deres fremstilling og anvendelse | |
NO985974L (no) | Piperidineddiksyrederivater og deres anvendelse ved behandling av trombose-sykdommer | |
DK0829470T3 (da) | 2-Cyano-3,5-dihydroxy-hex-2-en-carboxylsyreamidderivater, fremgangsmåde til deres fremstilling og deres anvendelse som læge | |
ES8101045A1 (es) | Procedimiento para la preparacion de derivados de acidos pi-rrolidinilsulfamoilbenzoicos sustituidos |