HK1014369A1 - Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides - Google Patents
Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotidesInfo
- Publication number
- HK1014369A1 HK1014369A1 HK98115739A HK98115739A HK1014369A1 HK 1014369 A1 HK1014369 A1 HK 1014369A1 HK 98115739 A HK98115739 A HK 98115739A HK 98115739 A HK98115739 A HK 98115739A HK 1014369 A1 HK1014369 A1 HK 1014369A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- carbon atoms
- group
- oligonucleotide
- atoms
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 125000000524 functional group Chemical group 0.000 title 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical class [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000002228 disulfide group Chemical group 0.000 abstract 3
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001787 chalcogens Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002009 diols Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000002515 oligonucleotide synthesis Methods 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73105591A | 1991-07-15 | 1991-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1014369A1 true HK1014369A1 (en) | 1999-09-24 |
Family
ID=24937868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98115739A HK1014369A1 (en) | 1991-07-15 | 1998-12-24 | Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0523978B1 (ja) |
| JP (3) | JP2899111B2 (ja) |
| AT (1) | ATE179982T1 (ja) |
| AU (3) | AU664184B2 (ja) |
| CA (1) | CA2073846C (ja) |
| DE (1) | DE69229149T2 (ja) |
| DK (1) | DK0523978T3 (ja) |
| ES (1) | ES2131060T3 (ja) |
| GR (1) | GR3030260T3 (ja) |
| HK (1) | HK1014369A1 (ja) |
| IE (1) | IE922292A1 (ja) |
| PT (1) | PT100691B (ja) |
| WO (1) | WO1993002093A1 (ja) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| AU2003200284B2 (en) * | 1998-03-27 | 2006-11-02 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| EP1632496A1 (en) * | 1998-06-22 | 2006-03-08 | Affymetrix, Inc. | Reagents and methods for solid phase synthesis and display |
| US6399578B1 (en) | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| KR20020059808A (ko) | 1999-11-28 | 2002-07-13 | 와이즈먼 앤드루 | 항체 친화도에 기초한 루프스 치료방법 및 그것의 사용을위한 스크리닝 방법과 조성물 |
| DE10013600A1 (de) * | 2000-03-18 | 2002-01-10 | Aventis Res & Tech Gmbh & Co | Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung |
| US7255868B2 (en) | 2001-06-21 | 2007-08-14 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—I |
| DE10163836A1 (de) | 2001-12-22 | 2003-07-10 | Friz Biochem Gmbh | Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren |
| JP4495670B2 (ja) * | 2005-12-27 | 2010-07-07 | 三井化学株式会社 | メルカプトアルキルホスホニウム化合物の製造法 |
| US20120302737A1 (en) | 2009-09-16 | 2012-11-29 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| EP2659269B1 (en) | 2010-12-23 | 2016-10-26 | Roche Diagniostics GmbH | Detection of a posttranslationally modified polypeptide by a bi-valent binding agent |
| JP6162044B2 (ja) | 2010-12-23 | 2017-07-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 結合剤 |
| JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
| CN104105711B (zh) | 2012-02-10 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | 单链抗体及其他异多聚体 |
| FR2989086B1 (fr) * | 2012-04-04 | 2017-03-24 | Centre Nat De La Rech Scient (Cnrs) | Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies |
| FR2989089B1 (fr) | 2012-04-04 | 2020-02-07 | Etablissement Francais Du Sang | Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques |
| CN104395339A (zh) | 2012-06-27 | 2015-03-04 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途 |
| CN104411718B (zh) | 2012-06-27 | 2018-04-24 | 弗·哈夫曼-拉罗切有限公司 | 用于制备包含特异性结合靶的至少一种结合实体的抗体Fc区缀合物的方法及其用途 |
| EP2928877B1 (en) * | 2012-12-06 | 2020-01-22 | Merck Sharp & Dohme Corp. | Disulfide masked prodrug compositions and methods |
| EP3227332B1 (en) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
| WO2023192830A2 (en) * | 2022-03-28 | 2023-10-05 | Empirico Inc. | Modified oligonucleotides |
| WO2023192828A2 (en) * | 2022-03-28 | 2023-10-05 | Empirico Inc. | Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3225063A (en) * | 1962-05-21 | 1965-12-21 | Scott Paper Co | Organic cyclic carbonates |
| US4191668A (en) * | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
| US4220565A (en) * | 1979-01-18 | 1980-09-02 | Scripps Clinic & Research Foundation | Immunochemical conjugates: method and composition |
| US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
| DK160818C (da) * | 1983-12-30 | 1991-10-07 | Hoffmann La Roche | N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse |
| US4575558A (en) * | 1984-02-15 | 1986-03-11 | American Hospital Supply Corporation | Preparation of optically active 1,3-dioxolane-4-methanol compounds |
| US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| CA1291423C (en) * | 1985-10-24 | 1991-10-29 | Ping W. Tang | Biochemical reagent |
| DE3811005A1 (de) * | 1988-03-31 | 1989-10-19 | Bayer Ag | Thionophosphor(phosphon)saeureamidester |
| EP0354323A3 (en) * | 1988-08-12 | 1990-06-13 | American Cyanamid Company | Antidiabetic phosphates |
| DE3916871A1 (de) * | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
| CA2059288C (en) * | 1989-06-22 | 2001-02-13 | Jean Riess | Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties |
| DE3937116A1 (de) * | 1989-11-03 | 1991-05-08 | Dainippon Ink & Chemicals | Verfahren zur herstellung cyclocarbonathaltiger ester |
-
1992
- 1992-07-14 CA CA002073846A patent/CA2073846C/en not_active Expired - Fee Related
- 1992-07-14 IE IE229292A patent/IE922292A1/en not_active IP Right Cessation
- 1992-07-14 JP JP5502916A patent/JP2899111B2/ja not_active Expired - Fee Related
- 1992-07-14 WO PCT/US1992/005897 patent/WO1993002093A1/en active Search and Examination
- 1992-07-14 AU AU19685/92A patent/AU664184B2/en not_active Ceased
- 1992-07-15 DK DK92306477T patent/DK0523978T3/da active
- 1992-07-15 DE DE69229149T patent/DE69229149T2/de not_active Expired - Fee Related
- 1992-07-15 EP EP92306477A patent/EP0523978B1/en not_active Expired - Lifetime
- 1992-07-15 AT AT92306477T patent/ATE179982T1/de not_active IP Right Cessation
- 1992-07-15 ES ES92306477T patent/ES2131060T3/es not_active Expired - Lifetime
- 1992-07-15 PT PT100691A patent/PT100691B/pt not_active IP Right Cessation
-
1995
- 1995-12-20 AU AU40580/95A patent/AU686911B2/en not_active Ceased
-
1997
- 1997-11-12 AU AU45202/97A patent/AU703715B2/en not_active Ceased
-
1998
- 1998-12-02 JP JP34324698A patent/JP3188243B2/ja not_active Expired - Fee Related
- 1998-12-24 HK HK98115739A patent/HK1014369A1/xx not_active IP Right Cessation
-
1999
- 1999-05-19 GR GR990401353T patent/GR3030260T3/el unknown
-
2001
- 2001-03-08 JP JP2001065808A patent/JP3488435B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT100691A (pt) | 1993-10-29 |
| JPH07500576A (ja) | 1995-01-19 |
| DK0523978T3 (da) | 1999-11-01 |
| JP3188243B2 (ja) | 2001-07-16 |
| JP2899111B2 (ja) | 1999-06-02 |
| WO1993002093A1 (en) | 1993-02-04 |
| PT100691B (pt) | 1999-06-30 |
| EP0523978B1 (en) | 1999-05-12 |
| AU703715B2 (en) | 1999-04-01 |
| AU686911B2 (en) | 1998-02-12 |
| CA2073846C (en) | 2007-09-18 |
| ES2131060T3 (es) | 1999-07-16 |
| DE69229149T2 (de) | 1999-12-09 |
| AU664184B2 (en) | 1995-11-09 |
| CA2073846A1 (en) | 1993-01-16 |
| DE69229149D1 (de) | 1999-06-17 |
| JP3488435B2 (ja) | 2004-01-19 |
| AU1968592A (en) | 1993-01-21 |
| GR3030260T3 (en) | 1999-08-31 |
| JPH11228592A (ja) | 1999-08-24 |
| ATE179982T1 (de) | 1999-05-15 |
| IE922292A1 (en) | 1993-01-27 |
| AU4058095A (en) | 1996-03-14 |
| JP2001302684A (ja) | 2001-10-31 |
| AU4520297A (en) | 1998-02-19 |
| EP0523978A1 (en) | 1993-01-20 |
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