HK1005139A1 - Cycloalkano-indole-and-azaindole derivatives - Google Patents

Cycloalkano-indole-and-azaindole derivatives

Info

Publication number
HK1005139A1
HK1005139A1 HK98104346A HK98104346A HK1005139A1 HK 1005139 A1 HK1005139 A1 HK 1005139A1 HK 98104346 A HK98104346 A HK 98104346A HK 98104346 A HK98104346 A HK 98104346A HK 1005139 A1 HK1005139 A1 HK 1005139A1
Authority
HK
Hong Kong
Prior art keywords
opt
substd
alkyl
phenyl
alkoxy
Prior art date
Application number
HK98104346A
Other languages
English (en)
Inventor
Ulrich Mueller
Richard Connell
Siegfried Goldmann
Rudi Grutzmann
Martin Beuck
Hilmar Bischoff
Dirk Denzer
Anke Domdey-Bette
Stefan Wohlfeil
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of HK1005139A1 publication Critical patent/HK1005139A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK98104346A 1994-10-04 1998-05-19 Cycloalkano-indole-and-azaindole derivatives HK1005139A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4435477A DE4435477A1 (de) 1994-10-04 1994-10-04 Cycloalkano-indol- und -azaindol-derivate

Publications (1)

Publication Number Publication Date
HK1005139A1 true HK1005139A1 (en) 1998-12-24

Family

ID=6529939

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104346A HK1005139A1 (en) 1994-10-04 1998-05-19 Cycloalkano-indole-and-azaindole derivatives

Country Status (36)

Country Link
US (6) US5684014A (zh)
EP (1) EP0705831B1 (zh)
JP (1) JP3901234B2 (zh)
KR (1) KR100355986B1 (zh)
CN (2) CN1050605C (zh)
AT (1) ATE255580T1 (zh)
AU (1) AU700609B2 (zh)
CA (1) CA2159546C (zh)
CZ (1) CZ291348B6 (zh)
DE (2) DE4435477A1 (zh)
DK (1) DK0705831T3 (zh)
DZ (1) DZ1934A1 (zh)
EE (1) EE03527B1 (zh)
ES (1) ES2211890T3 (zh)
FI (2) FI113048B (zh)
HK (1) HK1005139A1 (zh)
HN (1) HN1995009160A (zh)
HR (1) HRP950505B1 (zh)
HU (1) HU225052B1 (zh)
IL (3) IL129641A (zh)
MA (1) MA23683A1 (zh)
MY (1) MY117282A (zh)
NO (1) NO305365B1 (zh)
NZ (1) NZ280130A (zh)
PH (1) PH31400A (zh)
PL (1) PL183154B1 (zh)
PT (1) PT705831E (zh)
RU (1) RU2157803C2 (zh)
SG (1) SG63528A1 (zh)
SI (1) SI0705831T1 (zh)
SK (1) SK284260B6 (zh)
SV (1) SV1995000062A (zh)
TN (1) TNSN95098A1 (zh)
TW (1) TW448175B (zh)
UA (1) UA44700C2 (zh)
ZA (1) ZA958297B (zh)

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DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
DE19613549A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
US6774236B1 (en) 1996-04-04 2004-08-10 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
DE19615119A1 (de) 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide
DE19615265A1 (de) * 1996-04-18 1997-12-04 Bayer Ag Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
TR200003198T2 (tr) * 1998-05-01 2001-03-21 Eli Lilly And Company sPLA2 önleyicisi ester
EP0997465B1 (en) 1998-10-30 2004-02-04 Eli Lilly And Company Azaindole derivatives and their use as antithrombotic agents
AU4616200A (en) * 1999-05-25 2000-12-12 Yamanouchi Pharmaceutical Co., Ltd. Hydrazide derivatives
DE19929065A1 (de) * 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
NZ521386A (en) * 2000-03-15 2004-06-25 Aventis Pharma Gmbh Substituted beta-carbolines with lkB-kinase inhibiting activity
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
SK9562003A3 (en) * 2001-01-31 2004-04-06 Synaptic Pharma Corp Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
ZA200502496B (en) * 2002-02-28 2005-10-12 Japan Tobacco Inc Ester compound and medicinal use thereof.
AU2003241907A1 (en) * 2002-05-31 2003-12-19 Yamanouchi Pharmaceutical Co., Ltd. Tetrahydropyran derivative
WO2004063156A1 (en) * 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
WO2005051382A1 (ja) * 2003-11-28 2005-06-09 Astellas Pharma Inc. 脂質低下作用増強剤
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
SI1725234T1 (sl) 2004-03-05 2013-04-30 The Trustees Of The University Of Pennsylvania Postopki zdravljenja nepravilnosti ali bolezni povezanih s hiperlipidemijo in hiperholesterolemijo z minimiziranjem stranskih uäśinkov
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
EP1737460A2 (en) * 2004-04-09 2007-01-03 Janssen Pharmaceutica N.V. Intermittent dosing regimen for the treatment of overweight with mtp-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060030623A1 (en) * 2004-07-16 2006-02-09 Noboru Furukawa Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
FR2873694B1 (fr) * 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si Nouveaux aza-indoles inhibiteurs de la mtp et apob
US8101774B2 (en) * 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
MX2007004973A (es) * 2004-10-25 2007-06-14 Japan Tobacco Inc Formulacion solida con solubilidad y estabilidad mejoradas y metodo para producir la formulacion.
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
CA2609783A1 (en) * 2005-05-27 2006-12-07 Pfizer Products Inc. Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
CA2617654A1 (en) * 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
EP1951224A2 (en) * 2005-10-18 2008-08-06 Aegerion Pharmaceuticals Methods for treating disorders associated with hyperlipidemia in a mammal
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CA2642922C (en) * 2006-02-23 2011-08-02 Pfizer Limited Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US20080051427A1 (en) * 2006-05-18 2008-02-28 Fritz Schuckler Pharmaceutical Compositions and Methods of Using Same
CN101583593A (zh) 2006-11-13 2009-11-18 辉瑞产品公司 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
US20080161279A1 (en) * 2006-12-21 2008-07-03 Wisler Gerald L Methods of Treating Obesity
RU2338745C1 (ru) * 2007-03-21 2008-11-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2008124384A2 (en) * 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
MX2011001405A (es) * 2008-08-06 2011-03-21 Pfizer Ltd Compuestos de diazepina y diazocano como agonistas de mc4.
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US10759792B2 (en) 2014-09-05 2020-09-01 The Johns Hopkins University CaMKII inhibitors and uses thereof
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CN110467560A (zh) 2018-05-09 2019-11-19 深圳微芯生物科技股份有限公司 一种苯基氨基丙酸钠衍生物、其制备方法和应用
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JP2022504011A (ja) 2018-08-14 2022-01-13 オステオーク インコーポレイティド ピロロ－ジピリジン化合物

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DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4200954A1 (de) 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19613549A1 (de) 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
PH31400A (en) 1998-10-29
DE4435477A1 (de) 1996-04-11
US5684014A (en) 1997-11-04
JP3901234B2 (ja) 2007-04-04
EP0705831A2 (de) 1996-04-10
CZ291348B6 (cs) 2003-02-12
HN1995009160A (es) 2000-04-24
US6245775B1 (en) 2001-06-12
MA23683A1 (fr) 1996-07-01
FI20002693A (fi) 2000-12-08
TNSN95098A1 (fr) 1996-02-06
DK0705831T3 (da) 2004-04-05
US6479503B2 (en) 2002-11-12
DE59510839D1 (de) 2004-01-15
PL183154B1 (pl) 2002-05-31
AU3292095A (en) 1996-04-18
CA2159546A1 (en) 1996-04-05
US20020055635A1 (en) 2002-05-09
CA2159546C (en) 2010-12-14
IL115493A (en) 1999-10-28
US20020147209A1 (en) 2002-10-10
CN1224715A (zh) 1999-08-04
KR960014126A (ko) 1996-05-22
NZ280130A (en) 1996-05-28
FI113048B (fi) 2004-02-27
SK123995A3 (en) 1996-06-05
US20030149073A1 (en) 2003-08-07
NO305365B1 (no) 1999-05-18
RU2157803C2 (ru) 2000-10-20
EE9500071A (et) 1996-04-15
ATE255580T1 (de) 2003-12-15
SI0705831T1 (en) 2004-02-29
US6265431B1 (en) 2001-07-24
CZ256795A3 (en) 1996-04-17
ZA958297B (en) 1996-05-06
MY117282A (en) 2004-06-30
HU225052B1 (en) 2006-05-29
IL129641A0 (en) 2000-02-29
SK284260B6 (sk) 2004-12-01
IL129641A (en) 2000-08-31
PT705831E (pt) 2004-04-30
CN1050605C (zh) 2000-03-22
CN1183111C (zh) 2005-01-05
DZ1934A1 (fr) 2002-02-17
FI954681A0 (fi) 1995-10-02
SG63528A1 (en) 1999-03-30
HRP950505B1 (en) 2002-04-30
HU9502891D0 (en) 1995-11-28
US6858622B2 (en) 2005-02-22
CN1130631A (zh) 1996-09-11
EP0705831B1 (de) 2003-12-03
HUT73240A (en) 1996-07-29
EP0705831A3 (de) 1997-01-22
KR100355986B1 (ko) 2003-01-06
HRP950505A2 (en) 1997-08-31
NO953930D0 (no) 1995-10-03
PL310756A1 (en) 1996-04-15
AU700609B2 (en) 1999-01-07
FI954681A (fi) 1996-04-05
SV1995000062A (es) 1996-07-10
EE03527B1 (et) 2001-10-15
TW448175B (en) 2001-08-01
JPH08225526A (ja) 1996-09-03
NO953930L (no) 1996-04-09
IL115493A0 (en) 1996-01-19
UA44700C2 (uk) 2002-03-15
FI108791B (fi) 2002-03-28
ES2211890T3 (es) 2004-07-16

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Legal Events

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PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110921