GT200900333A - Compuestos de quinolina adecuados para el tratamiento de transtornos que responden a la modulación del receptor de serotonina 5-ht6. - Google Patents
Compuestos de quinolina adecuados para el tratamiento de transtornos que responden a la modulación del receptor de serotonina 5-ht6.Info
- Publication number
- GT200900333A GT200900333A GT200900333A GT200900333A GT200900333A GT 200900333 A GT200900333 A GT 200900333A GT 200900333 A GT200900333 A GT 200900333A GT 200900333 A GT200900333 A GT 200900333A GT 200900333 A GT200900333 A GT 200900333A
- Authority
- GT
- Guatemala
- Prior art keywords
- compounds
- serotonine
- modulation
- receiver
- kinoline
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
LA PRESENTE INVENCIÓN SE RELACIONA CON NUEVOS COMPUESTOS DE QUINOLINA DE LA FÓRMULA I Y SALES DE LOS MISMOS. LOS COMPUESTOS TIENEN PROPIEDADES TERAPÉUTICAS VALIOSAS Y SON APROPIADOS, EN PARTICULAR, PARA TRATAR ENFERMEDADES QUE RESPONDEN A LA MODULACIÓN DEL RECEPTOR DE SEROTONINA 5-HT6. EN LA FÓRMULA I, R ES UNA PORCIÓN DE LA FÓRMULA EN DONDE * INDICA EL SITIO DE UNIÓN AL RADICAL QUINOLINILO Y EN DONDE A,B,X',Y,Q,R1,R2,R3,R4,R5,M,N,P,Q,RA, RB,X Y AR SON COMO SE DEFINEN EN LA REIVINDICACIÓN 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113962 | 2007-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200900333A true GT200900333A (es) | 2015-10-14 |
Family
ID=39809897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200900333A GT200900333A (es) | 2007-08-07 | 2009-12-29 | Compuestos de quinolina adecuados para el tratamiento de transtornos que responden a la modulación del receptor de serotonina 5-ht6. |
Country Status (23)
Country | Link |
---|---|
US (2) | US8293913B2 (es) |
EP (1) | EP2185555B1 (es) |
JP (1) | JP5501230B2 (es) |
KR (1) | KR20100039300A (es) |
CN (1) | CN101687866B (es) |
AU (1) | AU2008285652B2 (es) |
BR (1) | BRPI0812853A2 (es) |
CA (1) | CA2691529C (es) |
CO (1) | CO6251268A2 (es) |
CR (1) | CR11187A (es) |
DO (1) | DOP2009000291A (es) |
EC (1) | ECSP099831A (es) |
ES (1) | ES2574154T3 (es) |
GT (1) | GT200900333A (es) |
HK (1) | HK1143588A1 (es) |
IL (1) | IL202706A (es) |
MX (1) | MX2009013956A (es) |
NZ (1) | NZ581986A (es) |
RU (1) | RU2483068C2 (es) |
TW (1) | TWI478919B (es) |
UA (1) | UA99626C2 (es) |
WO (1) | WO2009019286A1 (es) |
ZA (1) | ZA200909075B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
MA38982A1 (fr) | 2013-11-26 | 2017-09-29 | Hoffmann La Roche | Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl |
CN106103446B (zh) | 2014-03-26 | 2019-07-30 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
KR102315014B1 (ko) * | 2014-04-30 | 2021-10-20 | 카티바, 인크. | 가스 쿠션 장비 및 기판 코팅 기술 |
CN108026077B (zh) | 2015-09-04 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 苯氧基甲基衍生物 |
MA42923A (fr) * | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
MA42918A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
WO2017050792A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
JP6845230B2 (ja) * | 2015-09-24 | 2021-03-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | デュアルatx/ca阻害剤としての新規な二環式化合物 |
AR106515A1 (es) * | 2015-10-29 | 2018-01-24 | Bayer Cropscience Ag | Sililfenoxiheterociclos trisustituidos y análogos |
WO2017157929A1 (en) * | 2016-03-14 | 2017-09-21 | AbbVie Deutschland GmbH & Co. KG | Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor |
MA49879A (fr) | 2017-03-16 | 2020-06-24 | Hoffmann La Roche | Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca |
CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
JP7390401B2 (ja) * | 2019-05-30 | 2023-12-01 | シャンハイ インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | 縮合環化合物、その製造方法及び用途 |
CN117561058A (zh) * | 2021-06-26 | 2024-02-13 | 塞迪拉治疗股份有限公司 | Cdk2抑制剂及其使用方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0861236T4 (da) * | 1995-11-13 | 2006-12-18 | Sanofi Aventis Deutschland | Cykliske og heterocykliske N-substituerede alphaiminohydroxam- og carboxylsyrer |
GB9803411D0 (en) * | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
DE10000739A1 (de) | 2000-01-11 | 2001-07-12 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
PL209872B1 (pl) * | 2002-03-27 | 2011-10-31 | Glaxo Group Ltd | Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja |
GB0321473D0 (en) * | 2003-09-12 | 2003-10-15 | Glaxo Group Ltd | Novel compounds |
GB0322510D0 (en) * | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
CA2543710A1 (en) * | 2003-11-03 | 2005-05-12 | Warner-Lambert Company Llc | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
DE102004038268A1 (de) * | 2004-08-06 | 2006-03-16 | Sanofi-Aventis Deutschland Gmbh | Substituierte, bizyklische 8-Pyrrolidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
GB0425548D0 (en) | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Radiolabelled ligands |
WO2006113704A2 (en) * | 2005-04-18 | 2006-10-26 | Neurogen Corporation | Subtituted heteroaryl cb1 antagonists |
ES2341489T3 (es) * | 2005-07-27 | 2010-06-21 | F.Hoffmann-La Roche Ag | Derivados de 4-ariloxi quinolina como moduladores de 5-ht6. |
GB0519765D0 (en) | 2005-09-28 | 2005-11-09 | Glaxo Group Ltd | Novel compounds |
-
2008
- 2008-08-06 RU RU2010108282/04A patent/RU2483068C2/ru not_active IP Right Cessation
- 2008-08-06 WO PCT/EP2008/060335 patent/WO2009019286A1/en active Application Filing
- 2008-08-06 US US12/664,394 patent/US8293913B2/en active Active
- 2008-08-06 KR KR1020097027612A patent/KR20100039300A/ko not_active Application Discontinuation
- 2008-08-06 NZ NZ581986A patent/NZ581986A/en not_active IP Right Cessation
- 2008-08-06 AU AU2008285652A patent/AU2008285652B2/en not_active Ceased
- 2008-08-06 MX MX2009013956A patent/MX2009013956A/es active IP Right Grant
- 2008-08-06 EP EP08786942.6A patent/EP2185555B1/en active Active
- 2008-08-06 BR BRPI0812853-7A2A patent/BRPI0812853A2/pt not_active IP Right Cessation
- 2008-08-06 ES ES08786942.6T patent/ES2574154T3/es active Active
- 2008-08-06 JP JP2010519460A patent/JP5501230B2/ja not_active Expired - Fee Related
- 2008-08-06 CN CN200880023108.5A patent/CN101687866B/zh not_active Expired - Fee Related
- 2008-08-06 UA UAA201002519A patent/UA99626C2/ru unknown
- 2008-08-06 CA CA2691529A patent/CA2691529C/en not_active Expired - Fee Related
- 2008-08-07 TW TW097130141A patent/TWI478919B/zh active
-
2009
- 2009-12-13 IL IL202706A patent/IL202706A/en not_active IP Right Cessation
- 2009-12-18 ZA ZA2009/09075A patent/ZA200909075B/en unknown
- 2009-12-28 DO DO2009000291A patent/DOP2009000291A/es unknown
- 2009-12-29 GT GT200900333A patent/GT200900333A/es unknown
- 2009-12-29 CO CO09148549A patent/CO6251268A2/es active IP Right Grant
- 2009-12-29 EC EC2009009831A patent/ECSP099831A/es unknown
-
2010
- 2010-01-04 CR CR11187A patent/CR11187A/es unknown
- 2010-10-28 HK HK10110137.1A patent/HK1143588A1/zh not_active IP Right Cessation
-
2012
- 2012-09-13 US US13/613,344 patent/US8440694B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ZA200909075B (en) | 2013-03-27 |
NZ581986A (en) | 2012-02-24 |
ECSP099831A (es) | 2010-01-29 |
CR11187A (es) | 2010-05-27 |
EP2185555A1 (en) | 2010-05-19 |
KR20100039300A (ko) | 2010-04-15 |
CA2691529A1 (en) | 2009-02-12 |
CO6251268A2 (es) | 2011-02-21 |
EP2185555B1 (en) | 2016-03-16 |
IL202706A0 (en) | 2010-06-30 |
CN101687866B (zh) | 2014-06-04 |
UA99626C2 (ru) | 2012-09-10 |
WO2009019286A1 (en) | 2009-02-12 |
CA2691529C (en) | 2016-01-05 |
AU2008285652B2 (en) | 2013-09-05 |
ES2574154T3 (es) | 2016-06-15 |
TWI478919B (zh) | 2015-04-01 |
DOP2009000291A (es) | 2010-01-31 |
MX2009013956A (es) | 2010-04-30 |
US20100292271A1 (en) | 2010-11-18 |
JP5501230B2 (ja) | 2014-05-21 |
US8293913B2 (en) | 2012-10-23 |
IL202706A (en) | 2014-08-31 |
CN101687866A (zh) | 2010-03-31 |
RU2483068C2 (ru) | 2013-05-27 |
HK1143588A1 (zh) | 2011-01-07 |
AU2008285652A1 (en) | 2009-02-12 |
RU2010108282A (ru) | 2011-09-20 |
TW200914453A (en) | 2009-04-01 |
BRPI0812853A2 (pt) | 2014-12-23 |
JP2010535739A (ja) | 2010-11-25 |
US20130005703A1 (en) | 2013-01-03 |
US8440694B2 (en) | 2013-05-14 |
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