GT200200104A - ANTIBACTERIAL AGENTS - Google Patents

ANTIBACTERIAL AGENTS

Info

Publication number
GT200200104A
GT200200104A GT200200104A GT200200104A GT200200104A GT 200200104 A GT200200104 A GT 200200104A GT 200200104 A GT200200104 A GT 200200104A GT 200200104 A GT200200104 A GT 200200104A GT 200200104 A GT200200104 A GT 200200104A
Authority
GT
Guatemala
Prior art keywords
antibacterial agents
quinazolindiona
born
record
compounds
Prior art date
Application number
GT200200104A
Other languages
Spanish (es)
Inventor
Edmund Lee Ellsworth
Howard Daniel Hollis Showalter
Sharon Anne Powell
Joseph Peter Sanchez
James Alan Kerschen
Michael Andrew Stier
Tuan Phong Tran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200104A publication Critical patent/GT200200104A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

LA PRESENTE INVENCION SE REFIERE A AGENTES ANTIBACTERIANOS QUE TIENEN UNA ESTRUCTURA DE NUCLEO DE QUINAZOLINDIONA DE FORMULA GENERAL (I) EN DONDE J,K,R1,R2,R3,R4,R5,R6, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS NACEN DE LA NECESIDAD DE DESARROLLAR NUEVOS PRODUCTOS QUE PREVENGAN, LA APARICION CONTINUADA DE RESISTENCIA A ANTIBIOTICOS.THIS INVENTION REFERS TO ANTIBACTERIAL AGENTS WHO HAVE A QUINAZOLINDIONA NUCLEUS STRUCTURE OF GENERAL FORMULA (I) WHERE J, K, R1, R2, R3, R4, R5, R6, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. THESE COMPOUNDS ARE BORN FROM THE NEED TO DEVELOP NEW PRODUCTS THAT PREVENT THE CONTINUED APPEARANCE OF ANTIBIOTIC RESISTANCE.

GT200200104A 2001-06-19 2002-05-31 ANTIBACTERIAL AGENTS GT200200104A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29924901P 2001-06-19 2001-06-19

Publications (1)

Publication Number Publication Date
GT200200104A true GT200200104A (en) 2003-02-11

Family

ID=23153973

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200104A GT200200104A (en) 2001-06-19 2002-05-31 ANTIBACTERIAL AGENTS

Country Status (13)

Country Link
EP (1) EP1401830A2 (en)
JP (1) JP2005501021A (en)
AU (1) AU2002302894A1 (en)
BR (1) BR0210028A (en)
CA (1) CA2446963A1 (en)
DO (1) DOP2002000422A (en)
GT (1) GT200200104A (en)
HN (1) HN2002000150A (en)
MX (1) MXPA03009894A (en)
PA (1) PA8548401A1 (en)
PE (1) PE20030272A1 (en)
SV (1) SV2003001089A (en)
WO (1) WO2002102793A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026154A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
EP1687296A1 (en) * 2003-11-18 2006-08-09 Warner-Lambert Company LLC Antibacterial aminoquinazolidinedione derivatives
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
EP2686305B1 (en) 2011-03-14 2020-09-16 Impact Therapeutics, Inc. Quinazolinediones and their use
TWI527800B (en) 2011-04-01 2016-04-01 南京英派藥業有限公司 1-(arylmethyl)quinazoline-2,4(1h,3h)-diones as parp inhibitors and the use thereof
ME03300B (en) 2012-06-13 2019-07-20 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
EA038045B1 (en) 2015-02-20 2021-06-28 Инсайт Корпорейшн Bicyclic heterocycles as fgfr inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
CL2015003780A1 (en) 2015-12-30 2016-09-16 Univ Chile Pyrimido-isoquinolin-quinone derivative compounds, their salts, isomers, acceptable pharmaceutical tautomers; farm compositions; preparation procedure; and its use in the treatment of multiresistant bacterial and bacterial diseases.
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
EA202092649A1 (en) 2018-05-04 2021-06-21 Инсайт Корпорейшн FGFR INHIBITOR SALTS
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
CN111620866A (en) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 Cis-7, 7-difluoro-hexahydro-1H pyrrolo [3,4-c ] pyridine derivative and preparation method thereof
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
IL291901A (en) 2019-10-14 2022-06-01 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (en) 2019-12-04 2022-09-29 인사이트 코포레이션 Derivatives of FGFR inhibitors
KR20230003503A (en) 2020-04-14 2023-01-06 선오비온 파마슈티컬스 인코포레이티드 (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine for the treatment of neurological and psychiatric disorders
AR126102A1 (en) 2021-06-09 2023-09-13 Incyte Corp TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS

Family Cites Families (17)

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GB1311573A (en) * 1970-04-27 1973-03-28 Hisamitsu Pharmaceutical Co Quinazolinedione derivatives
GB1401549A (en) * 1972-07-07 1975-07-16 Hisamitsu Pharmaceutical Co Pyrido-2,3-d-pyrimidine-2,4-1h,3h- diones and methods of preparing them
JPS5758347B2 (en) * 1974-04-03 1982-12-09 Hisamitsu Pharmaceutical Co
JPS5761743B2 (en) * 1974-04-25 1982-12-25 Hisamitsu Pharmaceutical Co
DE2446543A1 (en) * 1974-09-28 1976-04-15 Hoechst Ag Monoazomethine pigments - from 3-hydroxy 4-formylnaphthalic acid or derivs.
DE2614148A1 (en) * 1976-04-02 1977-10-20 Henkel & Cie Gmbh OXIDIZING AGENTS, BLEACHING AGENTS AND DETERGENTS WITH A BLEACH ACTIVATOR CONTENT
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EP0896961A4 (en) * 1995-12-28 1999-04-07 Fuji Chem Ind Co Ltd Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
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JPH09295977A (en) * 1996-04-30 1997-11-18 Terumo Corp Pyridopyrimidine derivative and medicinal composition containing the same
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EE200200412A (en) * 2000-01-24 2003-10-15 Warner-Lambert Company 3-aminoquinazoline-2,4-dione as an antibacterial agent
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Also Published As

Publication number Publication date
CA2446963A1 (en) 2002-12-27
SV2003001089A (en) 2003-03-18
EP1401830A2 (en) 2004-03-31
WO2002102793A2 (en) 2002-12-27
AU2002302894A1 (en) 2003-01-02
JP2005501021A (en) 2005-01-13
PE20030272A1 (en) 2003-03-21
DOP2002000422A (en) 2002-12-30
MXPA03009894A (en) 2004-02-17
HN2002000150A (en) 2002-09-13
WO2002102793A3 (en) 2003-04-10
BR0210028A (en) 2004-06-22
PA8548401A1 (en) 2003-05-14

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