GB1311573A - Quinazolinedione derivatives - Google Patents

Quinazolinedione derivatives

Info

Publication number
GB1311573A
GB1311573A GB1023371A GB1023371A GB1311573A GB 1311573 A GB1311573 A GB 1311573A GB 1023371 A GB1023371 A GB 1023371A GB 1023371 A GB1023371 A GB 1023371A GB 1311573 A GB1311573 A GB 1311573A
Authority
GB
United Kingdom
Prior art keywords
compounds
alkylating
april
acylating agent
above formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1023371A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Publication of GB1311573A publication Critical patent/GB1311573A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1311573 1-Phenylquinazolinedione derivatives HISAMITSU PHARMACEUTICAL CO Inc 20 April 1971 [27 April 1970] 10233/71 Heading C2C The invention comprises compounds of formula wherein R 1 is alkyl (possibly substituted) or acyl, and R 2 , R 3 are each H, CF 3 , Cl, Br, F, Me, MeO or EtO. These compounds are prepared by reacting the corresponding precursor of the above formula in which R 1 is H, with an alkylating or acylating agent, preferably in presence of an organic or inorganic base; one exemplified method is to react the precursor first with (e.g.) NaH and then with the alkylating or acylating agent. Therapeutic compositions comprising compounds of the above formula have antiinflammatory and analgesic activity.
GB1023371A 1970-04-27 1971-04-20 Quinazolinedione derivatives Expired GB1311573A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3649470 1970-04-27

Publications (1)

Publication Number Publication Date
GB1311573A true GB1311573A (en) 1973-03-28

Family

ID=12471364

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1023371A Expired GB1311573A (en) 1970-04-27 1971-04-20 Quinazolinedione derivatives

Country Status (4)

Country Link
CH (1) CH546243A (en)
DE (1) DE2120663C3 (en)
FR (1) FR2100623B1 (en)
GB (1) GB1311573A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016166A (en) * 1973-12-14 1977-04-05 Hisamitsu Pharmaceutical Co., Inc. 1-Nitrophenylquinazoline-2,4(1H,3H)-diones
EP1667685A1 (en) * 2003-09-23 2006-06-14 Merck & Co., Inc. Quinazoline potassium channel inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005501021A (en) * 2001-06-19 2005-01-13 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Antibacterial agent

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016166A (en) * 1973-12-14 1977-04-05 Hisamitsu Pharmaceutical Co., Inc. 1-Nitrophenylquinazoline-2,4(1H,3H)-diones
EP1667685A1 (en) * 2003-09-23 2006-06-14 Merck & Co., Inc. Quinazoline potassium channel inhibitors
EP1667685A4 (en) * 2003-09-23 2009-04-29 Merck & Co Inc Quinazoline potassium channel inhibitors
US7906521B2 (en) 2003-09-23 2011-03-15 Merck Sharp & Dohme Corp. Quinazoline potassium channel inhibitors

Also Published As

Publication number Publication date
DE2120663B2 (en) 1975-02-06
FR2100623A1 (en) 1972-03-24
CH546243A (en) 1974-02-28
FR2100623B1 (en) 1976-04-16
DE2120663C3 (en) 1975-09-18
DE2166614B2 (en) 1976-09-16
DE2166614A1 (en) 1974-10-31
DE2120663A1 (en) 1971-11-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee