GR880100850A - New ciclosporin crystal form process for its production pharmceutical compositions containing it and its use - Google Patents

New ciclosporin crystal form process for its production pharmceutical compositions containing it and its use

Info

Publication number
GR880100850A
GR880100850A GR880100850A GR880100850A GR880100850A GR 880100850 A GR880100850 A GR 880100850A GR 880100850 A GR880100850 A GR 880100850A GR 880100850 A GR880100850 A GR 880100850A GR 880100850 A GR880100850 A GR 880100850A
Authority
GR
Greece
Prior art keywords
new
ciclosporin
production
compositions containing
crystal form
Prior art date
Application number
GR880100850A
Other languages
Greek (el)
Other versions
GR1002486B (en
Inventor
Danielle Dr Giron
Martin Dr List
Friedrich Dr Richter
Yasuyuki Uike
Hans Peter Dr Weber
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of GR880100850A publication Critical patent/GR880100850A/en
Publication of GR1002486B publication Critical patent/GR1002486B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Νέες φαρμακευτικές συνθέσεις, ειδικώτερον τοπικές μορφές, π.χ. δια δερματική ή τοπική χρήσιν οφθαλμική, και ενέσιμες μορφές π.χ. δια ένεσιν εντός της βλάβης ή εντός της αρθρώσεως, περιλαμβάνουσα κυκλοσπορίνη ως δραστικό συστατικό υπό ορθορομβική κρυσταλλική μορφή. Κυκλοσπορίνη υπό μη διαλυτοποιημένη ορθορομβική κρυσταλλική μορφή προτιμάται δια την χρήσιν εις συνθέσεις της εφευρέσεως, είναι νέα και αποτελεί επίσης μέρος της εφευρέσεως, μαζί με την χρήσιν της και μέθοδος παραγωγής της.ωNew pharmaceutical compositions, especially local forms, e.g. for skin or local use ophthalmic, and injectable forms e.g. by injection into the lesion or into the joint, containing cyclosporine as the active ingredient in the orthobromic crystalline form. Cyclosporine in the unsolved orthobromic crystalline form is preferred for use in composition compositions, is new and is also part of the invention, along with its usefulness and production method.

GR880100850A 1987-12-21 1988-12-20 New ciclosporin crystal form process for its production pharmceutical compositions containing it and its use GR1002486B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (2)

Publication Number Publication Date
GR880100850A true GR880100850A (en) 1994-03-31
GR1002486B GR1002486B (en) 1996-12-09

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100850A GR1002486B (en) 1987-12-21 1988-12-20 New ciclosporin crystal form process for its production pharmceutical compositions containing it and its use

Country Status (27)

Country Link
JP (1) JPH0791316B2 (en)
KR (1) KR100188305B1 (en)
AT (1) AT403163B (en)
AU (1) AU626274B2 (en)
BE (1) BE1002665A4 (en)
CA (1) CA1341396C (en)
CH (1) CH677926A5 (en)
CY (1) CY1799A (en)
DE (1) DE3843054C2 (en)
DK (1) DK175220B1 (en)
ES (1) ES2012580A6 (en)
FI (1) FI89065C (en)
FR (1) FR2624863B1 (en)
GB (1) GB2211848B (en)
GR (1) GR1002486B (en)
HK (1) HK102894A (en)
HU (1) HU203564B (en)
IE (1) IE62006B1 (en)
IL (1) IL88719A0 (en)
IT (1) IT1235356B (en)
LU (1) LU87409A1 (en)
MY (1) MY103943A (en)
NL (1) NL195096C (en)
NO (1) NO177228C (en)
NZ (1) NZ227384A (en)
SE (1) SE503174C2 (en)
SG (1) SG99494G (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ATE147619T1 (en) * 1992-05-13 1997-02-15 Sandoz Ag OPTHALMIC COMPOSITIONS CONTAINING A CYCLOSPORIN
ES2168271T3 (en) 1992-09-25 2002-06-16 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS.
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US6262054B1 (en) 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
DE29824679U1 (en) 1997-01-30 2002-03-28 Novartis Ag Pharmaceutical compositions
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (en) * 2005-10-11 2010-04-21 山东新时代药业有限公司 High purity cyclosporin A preparation method
JP6163482B2 (en) * 2011-05-27 2017-07-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Crystalline form of cyclosporin A, process for its preparation and process for its use
JP6368244B2 (en) * 2011-11-15 2018-08-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Autoclavable cyclosporin A2 suspension
CA2856044C (en) 2011-11-15 2016-11-29 Allergan, Inc. Sustained action formulation of cyclosporin form 2
EP2780358B1 (en) * 2011-11-15 2016-03-23 Allergan, Inc. Cyclosporine a form 2 and method of making same
ES2791751T3 (en) 2011-11-15 2020-11-05 Allergan Inc Suspensions of cyclosporin A form 2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
DE2819094A1 (en) * 1977-05-10 1978-11-23 Sandoz Ag CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
M. WINDHOLZ et al.: "The Merck Index", edition 10, 1983, page 396, Merck & Co., Inc., Raywah, NJ, US; *

Also Published As

Publication number Publication date
KR100188305B1 (en) 1999-06-01
DK705488A (en) 1989-06-22
FR2624863A1 (en) 1989-06-23
IE62006B1 (en) 1994-12-14
JPH01211598A (en) 1989-08-24
AU626274B2 (en) 1992-07-30
HK102894A (en) 1994-09-30
JPH0791316B2 (en) 1995-10-04
DE3843054A1 (en) 1989-07-27
NO177228C (en) 1995-08-09
GB2211848A (en) 1989-07-12
CA1341396C (en) 2002-11-05
MY103943A (en) 1993-10-30
NO885625D0 (en) 1988-12-19
NO177228B (en) 1995-05-02
CY1799A (en) 1995-02-17
GR1002486B (en) 1996-12-09
KR890009975A (en) 1989-08-05
DK175220B1 (en) 2004-07-12
AT403163B (en) 1997-11-25
ATA309588A (en) 1997-04-15
FI885869A (en) 1989-06-22
SE8804570L (en) 1989-06-22
FI885869A0 (en) 1988-12-19
DK705488D0 (en) 1988-12-19
SE8804570D0 (en) 1988-12-19
CH677926A5 (en) 1991-07-15
FI89065C (en) 1993-09-30
HU203564B (en) 1991-08-28
IL88719A0 (en) 1989-07-31
DE3843054C2 (en) 2003-08-21
IE883779L (en) 1989-06-21
ES2012580A6 (en) 1990-04-01
IT8848690A0 (en) 1988-12-20
NL195096C (en) 2004-02-09
SG99494G (en) 1994-10-28
GB8829556D0 (en) 1989-02-08
FI89065B (en) 1993-04-30
FR2624863B1 (en) 1991-04-26
GB2211848B (en) 1991-11-06
NL8803125A (en) 1989-07-17
HUT49893A (en) 1989-11-28
NO885625L (en) 1989-06-22
SE503174C2 (en) 1996-04-15
BE1002665A4 (en) 1991-04-30
LU87409A1 (en) 1989-07-07
AU2705588A (en) 1989-06-22
IT1235356B (en) 1992-06-30
NZ227384A (en) 1991-09-25

Similar Documents

Publication Publication Date Title
GR880100850A (en) New ciclosporin crystal form process for its production pharmceutical compositions containing it and its use
DE69727158D1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING A MIXTURE OF SELF-CROSS-LINKED AND NON-SELF-CROSSLINKED HYALURONIC ACID FOR THE TREATMENT OF ARTHROPATHIES
DE69432087D1 (en) 6-amino-purine derivatives with PDE-IV inhibitory activity
ES2161291T3 (en) N- (INDOL-2-CARBONIL) AMIDAS AND DERIVATIVES AS INHIBITORS OF THE GLUCOGENO FOSFORILASA.
ES2058185T3 (en) DERIVATIVES OF CAMPTOTECINA AND PROCEDURE FOR ITS PREPARATION.
DE3779500D1 (en) LEVODOPA METHYL ESTER CONTAINING PHARMACEUTICAL COMPOSITIONS, THEIR PRODUCTION AND THERAPEUTIC USE.
BR9711447A (en) Use of glp-1 analogs in the treatment of radio myocardial infarction
DE69329073D1 (en) TAXOL ENCLOSED IN LIPOSOMES AND METHOD OF USE
FI954130A0 (en) Heterocyclic compounds and their preparation and use
FI954131A (en) Heterocyclic compounds and their preparation and use
BR0014381A (en) Derivatives of 5-beta-sapogenin and pseudosapogenin and their use in the treatment of dementia
BR9709845A (en) Aqueous preparation of insulin parenteral pharmaceutical formulation and process to increase the chemical stability of an insulin preparation
FI96030B (en) Process for the preparation of therapeutically active substituted tetralines, chromones and with these related compounds, as well as intermediates useful in the process
GR1000611B (en) Method for preparating ocular eyclosporine compositions
GR890100562A (en) Stale bioactive somatotropins
BR9711647A (en) New derivatives of Dicafeoilquímica, their use, compositions with them and treatment methods using them.
ES2080736T3 (en) USE OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES IN THE TREATMENT OF NEUROLOGICAL DISORDERS.
DK0383417T3 (en) Flag salivary plasminogen activator v-PAalfa1
EA200000242A1 (en) FANHINONA APPLICATION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
DE3773017D1 (en) PREPARATION FOR INJECTION CONTAINING NICORANDIL.
ES2169037T3 (en) CONJUGADOS POLIETILENGLICOL-HIRUDINA, ITS PREPARATION PROCEDURE AND ITS USE FOR THE TROMBOSIS TREATMENT.
ATE213233T1 (en) SUBSTITUTED CAPROLACTAMES AND THEIR DERIVATIVES USABLE FOR THE TREATMENT OF HIV DISEASE
FI943354A0 (en) Bifunctional urokinase variants with improved fibrinolytic properties and thrombin inhibitory action
MX9203140A (en) DERIVATIVES OF 4 PHENYL-4 (N- (FENYL) AMIDO) -PIPERIDINE AND PHARMACEUTICAL COMPOSITIONS, AS WELL AS THE METHOD APPLIED TO SUCH COMPOUNDS.
ES534859A0 (en) PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 1- (4'-ALQUILSULFONILFENIL) -2-AMINO-1,3-PROPANDIOL N-SUBSTITUTED

Legal Events

Date Code Title Description
MA Right expired