GR862102B - Chemical process - Google Patents

Chemical process

Info

Publication number
GR862102B
GR862102B GR862102A GR860102102A GR862102B GR 862102 B GR862102 B GR 862102B GR 862102 A GR862102 A GR 862102A GR 860102102 A GR860102102 A GR 860102102A GR 862102 B GR862102 B GR 862102B
Authority
GR
Greece
Prior art keywords
chemical process
chemical
Prior art date
Application number
GR862102A
Other languages
English (en)
Inventor
Faruk Erol Ali
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858520153A external-priority patent/GB8520153D0/en
Priority claimed from GB868612579A external-priority patent/GB8612579D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of GR862102B publication Critical patent/GR862102B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR862102A 1985-08-10 1986-08-08 Chemical process GR862102B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858520153A GB8520153D0 (en) 1985-08-10 1985-08-10 Chemical process
GB868612579A GB8612579D0 (en) 1986-05-23 1986-05-23 Chemical process

Publications (1)

Publication Number Publication Date
GR862102B true GR862102B (en) 1986-12-30

Family

ID=26289644

Family Applications (1)

Application Number Title Priority Date Filing Date
GR862102A GR862102B (en) 1985-08-10 1986-08-08 Chemical process

Country Status (17)

Country Link
US (1) US4902801A (el)
EP (1) EP0223334B1 (el)
JP (2) JPH0696551B2 (el)
AU (1) AU582456B2 (el)
BG (1) BG61319B2 (el)
CA (1) CA1310649C (el)
CY (1) CY1708A (el)
DE (1) DE3680184D1 (el)
DK (1) DK169730B1 (el)
ES (2) ES2000603A6 (el)
GR (1) GR862102B (el)
HK (1) HK69793A (el)
IE (1) IE58831B1 (el)
MX (1) MX171822B (el)
NZ (1) NZ217141A (el)
PT (1) PT83179B (el)
SG (1) SG27793G (el)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714707D0 (en) * 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi
JPH04288059A (ja) * 1991-03-14 1992-10-13 Nippon Paint Co Ltd 複素環化合物及びその製造法
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
WO1997005879A1 (en) * 1995-08-03 1997-02-20 Fmc Corporation Reductions using hydrides
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
EP1384711A1 (en) 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Optical resolution of a piperidine derivative
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
WO1998013319A1 (en) * 1996-09-24 1998-04-02 Fmc Corporation Novel reduction compositions and processes for making the same
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
DE69840909D1 (de) * 1997-04-07 2009-07-30 Univ Georgetown Analoge von kokain
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
HUP0003958A3 (en) 1997-05-29 2001-06-28 Smithkline Beecham Plc Process for preparation of 4-aryl-piperidines and intermediates
AU3108097A (en) * 1997-06-10 1998-12-30 Synthon B.V. 4-phenylpiperidine compounds
EP0969002B1 (en) 1998-06-29 2003-08-27 SUMIKA FINE CHEMICALS Co., Ltd. L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
WO2000026187A1 (en) * 1998-11-02 2000-05-11 Synthon B.V. Process for producing 4-arylpiperidine-3-carbinols and related compounds
GB9915303D0 (en) * 1999-06-30 1999-09-01 Smithkline Beecham Plc Novel process
IT1313702B1 (it) * 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
GB9920147D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
AU1037701A (en) * 1999-10-20 2001-04-30 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
GB9924855D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel processes
GB9924882D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel process
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
WO2001085688A1 (en) * 2000-05-12 2001-11-15 Synthon B.V. TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS
US6833458B2 (en) 2000-06-05 2004-12-21 Development Center For Biotechnology Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates
WO2002028834A1 (en) * 2000-10-06 2002-04-11 Smithkline Beecham P.L.C. Process for the preparation of aryl-piperidine carbinols and intermediates thereof
WO2002053537A1 (en) * 2001-01-04 2002-07-11 Ferrer Internacional, S.A. Process for preparing (±) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
EP1362032A2 (en) * 2001-02-24 2003-11-19 Spurcourt Limited Process of preparing paroxetine and intermediates for use therein
EP1406624A4 (en) * 2001-06-13 2005-03-30 Teva Pharma METHOD FOR PRODUCING PAROXETIN, WHICH IS ESPECIALLY FREE OF ALKOXY POLLUTION
KR100477048B1 (ko) * 2002-07-05 2005-03-17 임광민 피페리딘 화합물의 새로운 제조방법
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
CN101205211B (zh) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 一种盐酸帕罗西汀重要中间体的制备方法
IN2013MU03596A (el) * 2013-11-18 2015-07-24 Piramal Entpr Ltd
CN104262255A (zh) * 2014-09-22 2015-01-07 四川大学 一种不对称催化合成γ-硝基吡唑酰胺化合物的方法
CN104402800A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的制备方法
WO2022269643A1 (en) * 2021-06-25 2022-12-29 Vihita Chem Private Limited An improved process for the preparation of intermediate for paroxetine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE625656A (el) * 1961-12-05
NL125654C (el) * 1963-12-17 1900-01-01
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
US3681327A (en) * 1970-07-01 1972-08-01 Exxon Research Engineering Co N-methylenethiophosphate derivatives of 1,3-thiazines and 1,4-thiazanes
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US3947460A (en) * 1974-06-27 1976-03-30 Sandoz, Inc. 5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones
EP0047516B1 (en) * 1980-09-04 1984-01-04 Toray Industries, Inc. Propylamine derivative and process of manufacturing the same
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT

Also Published As

Publication number Publication date
JPH07138228A (ja) 1995-05-30
AU582456B2 (en) 1989-03-23
JPH0696551B2 (ja) 1994-11-30
IE58831B1 (en) 1993-11-17
MX171822B (es) 1993-11-17
DK380986A (da) 1987-02-11
NZ217141A (en) 1989-06-28
JPS6239566A (ja) 1987-02-20
DK169730B1 (da) 1995-01-30
ES2005745A6 (es) 1989-03-16
ES2000603A6 (es) 1988-03-01
CA1310649C (en) 1992-11-24
EP0223334A1 (en) 1987-05-27
PT83179A (en) 1986-09-01
BG61319B2 (bg) 1997-05-30
HK69793A (en) 1993-07-30
EP0223334B1 (en) 1991-07-10
DE3680184D1 (de) 1991-08-14
CY1708A (en) 1994-01-14
PT83179B (pt) 1989-03-30
DK380986D0 (da) 1986-08-08
AU6101286A (en) 1987-02-12
US4902801A (en) 1990-02-20
IE862135L (en) 1987-02-10
JPH08809B2 (ja) 1996-01-10
SG27793G (en) 1993-05-21

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