JPS5671073A
(en)
*
|
1979-11-12 |
1981-06-13 |
Takeda Chem Ind Ltd |
Imidazole derivative
|
JPS5671074A
(en)
*
|
1979-11-12 |
1981-06-13 |
Takeda Chem Ind Ltd |
1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
|
US4338453A
(en)
*
|
1980-09-17 |
1982-07-06 |
The Upjohn Company |
Aminoalkyl-1,2,4-triazoles
|
GB2092569B
(en)
*
|
1981-02-05 |
1984-09-19 |
Farmos Oy |
Substituted imidazole derivatives and their preparation and use
|
DE3106150A1
(de)
*
|
1981-02-13 |
1982-09-16 |
Schering Ag, 1000 Berlin Und 4619 Bergkamen |
"verfahren zur herstellung von imidazolessigsaeurederivaten"
|
CA1181082A
(en)
*
|
1981-11-20 |
1985-01-15 |
Toni Dockner |
Substituted benzylimidazolium salts and microbicides containing these compounds
|
JPS58157768A
(ja)
*
|
1982-03-16 |
1983-09-19 |
Takeda Chem Ind Ltd |
4−クロロ−2−フエニルイミダゾ−ル−5−酢酸誘導体
|
US5138069A
(en)
*
|
1986-07-11 |
1992-08-11 |
E. I. Du Pont De Nemours And Company |
Angiotensin II receptor blocking imidazoles
|
CA1338238C
(en)
|
1988-01-07 |
1996-04-09 |
David John Carini |
Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
|
US4880804A
(en)
*
|
1988-01-07 |
1989-11-14 |
E. I. Du Pont De Nemours And Company |
Angiotensin II receptor blocking benzimidazoles
|
US5015651A
(en)
*
|
1988-01-07 |
1991-05-14 |
E. I. Du Pont De Nemours And Company |
Treatment of hypertension with 1,2,4-angiotensin II antagonists
|
US5093346A
(en)
*
|
1988-01-07 |
1992-03-03 |
E. I. Du Pont De Nemours And Company |
Substituted 1,2,4-triazole angiotensin II antagonists
|
US5189048A
(en)
*
|
1988-01-07 |
1993-02-23 |
E. I. Du Pont De Nemours And Company |
Substituted 1,2,3 triazole angiotensin II antagonists
|
US5210079A
(en)
*
|
1988-01-07 |
1993-05-11 |
E. I. Du Pont De Nemours And Company |
Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
|
US5315013A
(en)
*
|
1988-01-07 |
1994-05-24 |
E. I. Du Pont De Nemours And Company |
Substituted pyrazole angiotensin II antagonists
|
US5081127A
(en)
*
|
1988-01-07 |
1992-01-14 |
E. I. Du Pont De Nemours And Company |
Substituted 1,2,3-triazole angiotensin II antagonists
|
US5354867A
(en)
*
|
1988-12-06 |
1994-10-11 |
E. I. Du Pont De Nemours And Company |
Angiotensin II receptor blocking imidazoles
|
US4916129A
(en)
*
|
1989-01-19 |
1990-04-10 |
E. I. Du Pont De Nemours And Company |
Combination β-blocking/angiotensin II blocking antihypertensives
|
US5064825A
(en)
*
|
1989-06-01 |
1991-11-12 |
Merck & Co., Inc. |
Angiotensin ii antagonists
|
WO1991000281A2
(en)
|
1989-06-30 |
1991-01-10 |
E.I. Du Pont De Nemours And Company |
Fused-ring aryl substituted imidazoles
|
EP0409332A3
(en)
*
|
1989-07-19 |
1991-08-07 |
Merck & Co. Inc. |
Substituted triazoles as angiotensin ii antagonists
|
US5073566A
(en)
*
|
1989-11-30 |
1991-12-17 |
Eli Lilly And Company |
Angiotensin ii antagonist 1,3-imidazoles and use thereas
|
US5166206A
(en)
*
|
1990-03-30 |
1992-11-24 |
Merck & Co., Inc. |
Substituted pyrimidines, pyrimidinones and pyridopyrimidines
|
JPH0441481A
(ja)
*
|
1990-06-05 |
1992-02-12 |
Nippon Synthetic Chem Ind Co Ltd:The |
イミダゾール類のハロゲン化方法
|
US5374615A
(en)
*
|
1990-10-31 |
1994-12-20 |
E. R. Squibb & Sons, Inc. |
Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
|
US5153347A
(en)
*
|
1991-01-31 |
1992-10-06 |
E. R. Squibb & Sons, Inc. |
Phosphonate, phosphinate derivatives useful as antihypertensive agents
|
US5191086A
(en)
*
|
1991-03-19 |
1993-03-02 |
E.R. Squibb & Sons, Inc. |
Imidazole and benzimidazole derivatives
|
US5177074A
(en)
|
1991-03-26 |
1993-01-05 |
Merck & Co., Inc. |
Angiotensin ii antagonists incorporating a substituted thiophene or furan
|
US5506361A
(en)
*
|
1991-05-08 |
1996-04-09 |
Theupjohn Company |
Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
|
GB9110636D0
(en)
*
|
1991-05-16 |
1991-07-03 |
Glaxo Group Ltd |
Chemical compounds
|
US5332820A
(en)
*
|
1991-05-20 |
1994-07-26 |
E. I. Du Pont De Nemours And Company |
Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
|
US5294722A
(en)
*
|
1992-04-16 |
1994-03-15 |
E. R. Squibb & Sons, Inc. |
Process for the preparation of imidazoles useful in angiotensin II antagonism
|
US5401851A
(en)
*
|
1992-06-03 |
1995-03-28 |
Eli Lilly And Company |
Angiotensin II antagonists
|
US5612360A
(en)
*
|
1992-06-03 |
1997-03-18 |
Eli Lilly And Company |
Angiotensin II antagonists
|
KR960701023A
(ko)
*
|
1993-04-07 |
1996-02-24 |
도쿠시마 슈이치 |
피라졸 유도체(pyrazole derivatives)
|
DE4343613A1
(de)
*
|
1993-12-21 |
1995-06-22 |
Bayer Ag |
N-substituierte Aryl-trifluormethylimidazole
|
WO1995033730A1
(fr)
*
|
1994-06-09 |
1995-12-14 |
Nippon Soda Co., Ltd. |
Derive d'imidazole, procede de production et herbicide
|
US5859035A
(en)
*
|
1996-04-03 |
1999-01-12 |
Merck & Co., Inc. |
Arylheteroaryl inhibitors of farnesyl-protein transferase
|
US6080870A
(en)
*
|
1996-04-03 |
2000-06-27 |
Merck & Co., Inc. |
Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
|
JP2000504024A
(ja)
*
|
1996-04-03 |
2000-04-04 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル―タンパク質トランスフェラーゼ阻害剤
|
US6063930A
(en)
*
|
1996-04-03 |
2000-05-16 |
Merck & Co., Inc. |
Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
|
IT1295405B1
(it)
|
1997-09-30 |
1999-05-12 |
Merck Sharp & Dohme Italia S P |
Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
|
WO2006110037A2
(en)
*
|
2005-04-15 |
2006-10-19 |
Dishman Pharmaceuticals And Chemicals Ltd. |
Preparation of 2-substituted 4-chl0r0-5-f0rmylimidaz0les by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanξsulphonate) catalyst
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
US20100120694A1
(en)
|
2008-06-04 |
2010-05-13 |
Synergy Pharmaceuticals, Inc. |
Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
|
US7879802B2
(en)
|
2007-06-04 |
2011-02-01 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
EP2321341B1
(en)
|
2008-07-16 |
2017-02-22 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
WO2010014739A2
(en)
*
|
2008-07-29 |
2010-02-04 |
Kalypsys, Inc. |
Heterocyclic modulators of tgr5
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
EP2970384A1
(en)
|
2013-03-15 |
2016-01-20 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
CA2905435A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
BR112015030326A2
(pt)
|
2013-06-05 |
2017-08-29 |
Synergy Pharmaceuticals Inc |
Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
|