GR3020961T3 - Endothelin antagonist - Google Patents

Endothelin antagonist

Info

Publication number
GR3020961T3
GR3020961T3 GR960402316T GR960402316T GR3020961T3 GR 3020961 T3 GR3020961 T3 GR 3020961T3 GR 960402316 T GR960402316 T GR 960402316T GR 960402316 T GR960402316 T GR 960402316T GR 3020961 T3 GR3020961 T3 GR 3020961T3
Authority
GR
Greece
Prior art keywords
salt
peptide
amino acid
carbon atoms
pharmaceutically acceptable
Prior art date
Application number
GR960402316T
Other languages
English (en)
Inventor
Mitsuhiro Wakimasu
Takashi Kikuchi
Kazuki Kubo
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GR3020961T3 publication Critical patent/GR3020961T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR960402316T 1991-02-15 1996-09-05 Endothelin antagonist GR3020961T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2222091 1991-02-15
JP33723591 1991-12-19

Publications (1)

Publication Number Publication Date
GR3020961T3 true GR3020961T3 (en) 1996-12-31

Family

ID=26359402

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960402316T GR3020961T3 (en) 1991-02-15 1996-09-05 Endothelin antagonist

Country Status (7)

Country Link
US (1) US5352659A (el)
EP (1) EP0499266B1 (el)
AT (1) ATE140236T1 (el)
CA (1) CA2061246A1 (el)
DE (1) DE69212011T2 (el)
ES (1) ES2089256T3 (el)
GR (1) GR3020961T3 (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
US5352659A (en) * 1991-02-15 1994-10-04 Takeda Chemical Industries Endothelin analogs and uses thereof
EP0547317A1 (en) * 1991-12-19 1993-06-23 Takeda Chemical Industries, Ltd. Endothelin antagonists
US5614497A (en) * 1991-12-27 1997-03-25 Takeda Chemical Industries, Ltd. Peptide, production and use thereof
FR2687156B1 (fr) * 1992-02-12 1994-04-01 Roussel Uclaf Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.
CA2121724A1 (en) 1993-04-21 1994-10-22 Toshifumi Watanabe Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
CA2142985A1 (en) * 1993-06-25 1995-01-05 Kenji Shibata Endothelin-antagonizing peptide
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
DE19652374A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
NZ336898A (en) 1997-04-28 2001-10-26 Texas Biotechnology Corp Sulfonamides for treatment of endothelin-mediated disorders
BR0009497A (pt) 1999-03-29 2002-01-15 Procter & Gamble Ligantes de receptores de melanocortina
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
ES2285334T3 (es) 1999-12-31 2007-11-16 Encysive Pharmaceuticals, Inc Sulfonamidas y sus derivados como moduladores de la actividad de endotelina.
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
EP2001446A2 (en) * 2006-03-13 2008-12-17 Encysive Pharmaceuticals, Inc Formulations of sitaxsentan sodium
KR20080104149A (ko) * 2006-03-13 2008-12-01 엔싸이시브 파마슈티칼즈 인코퍼레이티드 확장기 심장 부전의 치료를 위한 방법 및 조성물
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
WO2008048371A2 (en) 2006-04-04 2008-04-24 Singulex, Inc. Methods and compositions for highly sensitive analysis of markers and detection of molecules
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
JP5678045B2 (ja) 2009-06-08 2015-02-25 シンギュレックス・インコーポレイテッド 高感度バイオマーカーパネル

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919726D0 (en) * 1989-08-31 1989-10-11 Fujisawa Pharmaceutical Co Ws7338 substances and preparation thereof
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
US5306808A (en) * 1990-02-26 1994-04-26 Takeda Chemical Industries, Ltd. Peptide derivatives having vasodilating activity
US5352659A (en) * 1991-02-15 1994-10-04 Takeda Chemical Industries Endothelin analogs and uses thereof

Also Published As

Publication number Publication date
EP0499266A1 (en) 1992-08-19
DE69212011D1 (de) 1996-08-14
DE69212011T2 (de) 1997-01-09
US5352659A (en) 1994-10-04
ES2089256T3 (es) 1996-10-01
EP0499266B1 (en) 1996-07-10
CA2061246A1 (en) 1992-08-16
ATE140236T1 (de) 1996-07-15

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