GR1004178B - Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια - Google Patents

Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια

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Publication number
GR1004178B
GR1004178B GR20010100550A GR2001100550A GR1004178B GR 1004178 B GR1004178 B GR 1004178B GR 20010100550 A GR20010100550 A GR 20010100550A GR 2001100550 A GR2001100550 A GR 2001100550A GR 1004178 B GR1004178 B GR 1004178B
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GR
Greece
Prior art keywords
detector
integrated
biomolecules
light source
chip
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GR20010100550A
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English (en)
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Priority to GR20010100550A priority Critical patent/GR1004178B/el
Priority to EP02793256A priority patent/EP1448978B1/en
Priority to DE60230801T priority patent/DE60230801D1/de
Priority to AU2002358915A priority patent/AU2002358915A1/en
Priority to PCT/GR2002/000061 priority patent/WO2003046527A1/en
Priority to US10/496,099 priority patent/US7319046B2/en
Priority to AT02793256T priority patent/ATE420345T1/de
Publication of GR1004178B publication Critical patent/GR1004178B/el

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Silicon Compounds (AREA)

Abstract

εφεύρεση αφορά σε ολοκληρωμένο οπτοηλεκτρονικό βιοαισθητήρα πυριτίου που είναι σε θέση να ανιχνεύει βιομόρια από την αλλαγή της οπτικής ζεύξης μεταξύ της ολοκληρωμένης πηγής φωτός και του ολοκληρωμένου ανιχνευτή που προκαλείται από την πρόσδεση των κατάλληλα επισημασμένων προς ανάλυση βιομορίων στα μόρια-αναγνώρισης που έχουν προηγουμένως ακινητοποιηθεί στην ολοκληρωμένη οπτική ίνα που συνδέειτην οπτική πηγή με τον ανιχνευτή. Η διάταξη περιλαμβάνει την οπτοηλεκτρονική ψηφίδα πυριτίου και την βιολογική της ενεργοποίηση. Η οπτοηλεκτρονική ψηφίδα κατασκευάζεται με μεθόδους κατασκευής ολοκληρωμένων κυκλωμάτων έτσι ώστε στο ίδιο υπόστρωμα πυριτίου να ολοκληρώνεται μονολιθικά η πηγή φωτός, ο ανιχνευτής και η οπτική ίνα που πραγματοποιεί την οπτική ζεύξη πηγής-ανιχνευτή. Η βιολογική της ενεργοποίηση γίνεται με την φυσικοχημική τροποποίηση της επιφάνειας της ψηφίδας έτσι ώστε να είναι δυνατή η πρόσδεση των βιομορίων αναγνώρισης στην επιφάνεια της οπτικής ίνας. Τα προς ανίχνευση βιομόρια (πρωτείνες η ολιγονουκλεοτίδια) επισημαίνονται με χρωμοφόρες ομάδες ή με νανοσωματίδια ή με ένζυμα και μετά την πρόσδεσή τους στα βιομόρια αναγνώρισης μειώνουν την οπτική ζεύξη οπτικής πηγής-ανιχνευτή παρέχοντας ένα μέτρο για τη συγκέντρωσή τους. ΰ
GR20010100550A 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια GR1004178B (el)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GR20010100550A GR1004178B (el) 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια
EP02793256A EP1448978B1 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
DE60230801T DE60230801D1 (de) 2001-11-29 2002-11-29 Integrierter optoelektronischer silizium-biosensor zum nachweis von mit chromophoren gruppen oder nanopartikeln markierten biomolekülen
AU2002358915A AU2002358915A1 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
PCT/GR2002/000061 WO2003046527A1 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
US10/496,099 US7319046B2 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
AT02793256T ATE420345T1 (de) 2001-11-29 2002-11-29 Integrierter optoelektronischer silizium- biosensor zum nachweis von mit chromophoren gruppen oder nanopartikeln markierten biomolekülen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20010100550A GR1004178B (el) 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια

Publications (1)

Publication Number Publication Date
GR1004178B true GR1004178B (el) 2003-03-05

Family

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Family Applications (1)

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GR20010100550A GR1004178B (el) 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια

Country Status (7)

Country Link
US (1) US7319046B2 (el)
EP (1) EP1448978B1 (el)
AT (1) ATE420345T1 (el)
AU (1) AU2002358915A1 (el)
DE (1) DE60230801D1 (el)
GR (1) GR1004178B (el)
WO (1) WO2003046527A1 (el)

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Also Published As

Publication number Publication date
DE60230801D1 (de) 2009-02-26
AU2002358915A1 (en) 2003-06-10
ATE420345T1 (de) 2009-01-15
US20050003520A1 (en) 2005-01-06
EP1448978A1 (en) 2004-08-25
US7319046B2 (en) 2008-01-15
EP1448978B1 (en) 2009-01-07
WO2003046527A1 (en) 2003-06-05

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