GR20050100623A - Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος - Google Patents

Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος

Info

Publication number
GR20050100623A
GR20050100623A GR20050100623A GR20050100623A GR20050100623A GR 20050100623 A GR20050100623 A GR 20050100623A GR 20050100623 A GR20050100623 A GR 20050100623A GR 20050100623 A GR20050100623 A GR 20050100623A GR 20050100623 A GR20050100623 A GR 20050100623A
Authority
GR
Greece
Prior art keywords
time
multianalyte
label
real
array
Prior art date
Application number
GR20050100623A
Other languages
English (en)
Other versions
GR1005589B (el
Inventor
Κωνσταντινος Μισιακος
Σωτηριος Κακαμπακος
Original Assignee
Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος"
Κωνσταντινος Μισιακος
Σωτηριος Κακαμπακος
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος", Κωνσταντινος Μισιακος, Σωτηριος Κακαμπακος filed Critical Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος"
Priority to GR20050100623A priority Critical patent/GR20050100623A/el
Priority to PCT/GR2006/000069 priority patent/WO2007074348A2/en
Publication of GR1005589B publication Critical patent/GR1005589B/el
Publication of GR20050100623A publication Critical patent/GR20050100623A/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Η παρούσα εφεύρεση αφορά βιαισθητήρα ταυτόχρονης ανίχνευσης πολλών αναλυτών στο ίδιο δείγμα με ή χωρίς τη χρήση ιχνηθετών που βασίζεται σε συστοιχία μονολιθικά ολοκληρωμένων σε πυρίτιο οπτοηλεκτρονικών μεταλλακτών σήματος αποτελούμενων από εκπομπό φωτός και οπτικό κυματοδηγό και οι οποίοι καταλήγουν σε ένα κοινό ανιχνευτή. Η συστοιχία των ανιχνευτών κατασκευάζεται μέσω μεθόδων κατασκευής ολοκληρωμένων κυκλωμάτων. Αυτή η διάταξη διευκολύνει τη συλλογή δεδομένων και απλουστεύει σημαντικά τα ηλεκτρονικά ελέγχου εφόσον απαιτεί μία και μόνο αλληλουχία ηλεκτρονικών ανάγνωσης ενώ η πολυπλεξία είναιδυνατή με επιλογή ενός εκπομπού κάθε φορά. Η ανίχνευση χωρίς χρήση ιχνηθετών σε πραγματικό χρόνο επιτυγχάνεται με επιφανειακή τροποποίηση των οπτικών κυματοδηγών με νανοσωματίδια ευγενών μετάλλων λόγω της μετατόπισης του φάσματος και του μεγέθους της οπτικής απορρόφησης των σωματιδίων που παρατηρείται όταν στην επιφάνειά τους συνδέονται βιομόρια. Επίσης, η ανίχνευση σε πραγματικό χρόνο χωρίς τη χρήση ιχνηθετών είναι δυνατή με τη δημιουργία εγκάρσιων προς τον άξονα του κυματοδηγού σχηματοποιημένωνστρώσεων ενός άλλου διηλεκτρικού που έχει ως αποτέλεσμα να μεταβάλλει την οπτική ζεύξη του εκπομπούφωτός με τον ανιχνευτή μέσω του κυματοδηγού όταν μεταβάλλεται ο δείκτης διαθλάσεως του περιβάλλοντος μέσου που υπέρκειται και γειτνιάζει με τον κυματοδηγό.
GR20050100623A 2005-12-27 2005-12-27 Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος GR20050100623A (el)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GR20050100623A GR20050100623A (el) 2005-12-27 2005-12-27 Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος
PCT/GR2006/000069 WO2007074348A2 (en) 2005-12-27 2006-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20050100623A GR20050100623A (el) 2005-12-27 2005-12-27 Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος

Publications (2)

Publication Number Publication Date
GR1005589B GR1005589B (el) 2007-07-18
GR20050100623A true GR20050100623A (el) 2007-07-23

Family

ID=37875668

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20050100623A GR20050100623A (el) 2005-12-27 2005-12-27 Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος

Country Status (2)

Country Link
GR (1) GR20050100623A (el)
WO (1) WO2007074348A2 (el)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020085784A1 (en) * 2000-12-06 2002-07-04 Reimer Ernest M. Integrated lightguide-optoelectronic devices
GB2377492A (en) * 2001-07-14 2003-01-15 Marconi Applied Techn Ltd Detecting analytes
WO2003046527A1 (en) * 2001-11-29 2003-06-05 National Centre For Scientific Research 'demokritos' Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
US20040046128A1 (en) * 1999-06-05 2004-03-11 Andreas Peter Abel Sensor platform and method for the determination of multiple analytes
US20050042651A1 (en) * 1999-01-08 2005-02-24 Vann Charles S. Integrated optics fiber array

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128846C2 (de) * 1991-08-30 1994-07-14 Rainer Dr Klein Integriert optischer Stoffsensor
US5253037A (en) * 1992-08-04 1993-10-12 Fci-Fiberchem, Inc. Optimal length for refractive index sensors
US5737457A (en) * 1994-02-25 1998-04-07 Fci - Fiberchem, Inc. Chip level waveguide sensor
US6137117A (en) * 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
CA2407701A1 (en) * 2000-04-28 2001-11-08 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
DE10137342A1 (de) * 2001-07-31 2003-03-06 Infineon Technologies Ag Biosensor und Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
US20070141567A1 (en) * 2002-11-13 2007-06-21 Wulfman David R Waveguide system for detection of fluorescently labeled nucleic acid sequences

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042651A1 (en) * 1999-01-08 2005-02-24 Vann Charles S. Integrated optics fiber array
US20040046128A1 (en) * 1999-06-05 2004-03-11 Andreas Peter Abel Sensor platform and method for the determination of multiple analytes
US20020085784A1 (en) * 2000-12-06 2002-07-04 Reimer Ernest M. Integrated lightguide-optoelectronic devices
GB2377492A (en) * 2001-07-14 2003-01-15 Marconi Applied Techn Ltd Detecting analytes
WO2003046527A1 (en) * 2001-11-29 2003-06-05 National Centre For Scientific Research 'demokritos' Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAMES S W ET AL: "OPTICAL FIBRE LONG-PERIOD GRATING SENSORS: CHARACTERISTICS AND APPLICATION", MEASUREMENT SCIENCE AND TECHNOLOGY, IOP, BRISTOL, GB, vol. 14, no. 5, May 2003 (2003-05-01), pages R49 - R61, XP001159859, ISSN: 0957-0233 *
MISIAKOS K ET AL: "A MONOLITHIC SILICON OPTOELECTRONIC TRANSDUCER AS A REAL-TIME AFFINITY BIOSENSOR", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 76, no. 5, 1 March 2004 (2004-03-01), pages 1366 - 1373, XP001196707, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
WO2007074348A2 (en) 2007-07-05
GR1005589B (el) 2007-07-18
WO2007074348A3 (en) 2007-10-11

Similar Documents

Publication Publication Date Title
US7212693B2 (en) Optical substance analyzer
CN102713609B (zh) 用于量化分子相互作用的结合和离解动力的装置和方法
JP2020508471A (ja) 集積化プラズモフォトニックバイオセンサおよび使用方法
AU2002358915A1 (en) Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
CN101351765A (zh) 用于基于波导的光学触摸屏的改进光学元件
EP1413876A3 (en) Multi-mode planar waveguide sensor, fabrication materials and techniques
Barshilia et al. Low-cost planar waveguide-based optofluidic sensor for real-time refractive index sensing
DE69909480D1 (de) Integriert-optischer Sensor
TW201140269A (en) Photoelectric feedback sensing system
WO2008007062A3 (en) A torsion sensor
Caucheteur et al. Cell sensing with near-infrared plasmonic optical fiber sensors
WO2009115847A1 (en) Monolithically integrated physical chemical and biological sensor arrays based on broad-band mach-zhender interferometry
WO2007082160A3 (en) Method for increasing signal intensity in an optical waveguide sensor
CN108267428A (zh) 便携式增强型表面等离子体共振生物传感器
JP2003156643A5 (el)
Jing et al. Chip-scale in situ salinity sensing based on a monolithic optoelectronic chip
US20130023042A1 (en) Metal buffer layer assisted guided mode resonance biosensor
CN105572074B (zh) 一种基于片上集成光波导生物传感器芯片的折射率检测方法
TW200724902A (en) Optic waveguide biiosensing device
ATE291218T1 (de) Abtasteinheit für eine optische positionsmesseinrichtung
GR20050100623A (el) Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος
CN209784187U (zh) 生物传感器
CN105628621B (zh) 一种无热的片上集成的光波导生物传感器芯片
WO2005001520A3 (en) Serial routing of optical signals
US20220082558A1 (en) Optical sensor, system and method for detecting pathogenic germs

Legal Events

Date Code Title Description
PG Patent granted