GB980592A - Novel benzoxazepine derivatives and a process for the manufacture thereof - Google Patents
Novel benzoxazepine derivatives and a process for the manufacture thereofInfo
- Publication number
- GB980592A GB980592A GB13379/63A GB1337963A GB980592A GB 980592 A GB980592 A GB 980592A GB 13379/63 A GB13379/63 A GB 13379/63A GB 1337963 A GB1337963 A GB 1337963A GB 980592 A GB980592 A GB 980592A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- halo
- bases
- alkyl group
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention comprises compounds of general formula <FORM:0980592/C2/1> wherein the broken lines denote bonds to optional substituents and the lower alkyl group contains 1-7 carbon atoms; and their salts with bases; and their preparation by treating a compound of formula <FORM:0980592/C2/2> wherein R represents a 1-halo-alkyl group, with N,N-dimethyl-formamide. Acylamino-benzoic acids II are prepared by acylation of an anthranilic acid with a 1-halo-acyl halide in the presence of an acid binding agent. Pharmaceutical preparations comprise compounds I, or non-toxic salts thereof with bases, in admixture with compatible pharmaceutical carriers. Tablets, capsules, solutions, suspensions and suppositories are mentioned for oral, parenteral and rectal administration. The compounds are diuretics.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18551262A | 1962-04-06 | 1962-04-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB980592A true GB980592A (en) | 1965-01-13 |
Family
ID=22681287
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB13379/63A Expired GB980592A (en) | 1962-04-06 | 1963-04-04 | Novel benzoxazepine derivatives and a process for the manufacture thereof |
GB13380/63A Expired GB980593A (en) | 1962-04-06 | 1963-04-04 | Novel quinazoline derivatives and a process for the manufacture thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB13380/63A Expired GB980593A (en) | 1962-04-06 | 1963-04-04 | Novel quinazoline derivatives and a process for the manufacture thereof |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE630572A (en) |
BR (1) | BR6348190D0 (en) |
CH (1) | CH428741A (en) |
ES (2) | ES286809A1 (en) |
GB (2) | GB980592A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4906635A (en) * | 1983-11-25 | 1990-03-06 | Schering Corporation | Carboxyalkyl dipeptides as antiglaucoma agents |
US5017567A (en) * | 1983-11-25 | 1991-05-21 | Schering Corporation | Carboxyalkyl dipeptides as antiglaucoma agents |
US4778795A (en) * | 1983-11-25 | 1988-10-18 | Schering Corporation | Carboxyalkyl dipeptides as antiglaucoma agents |
-
1963
- 1963-03-20 CH CH350763A patent/CH428741A/en unknown
- 1963-04-03 BR BR148190/63A patent/BR6348190D0/en unknown
- 1963-04-04 GB GB13379/63A patent/GB980592A/en not_active Expired
- 1963-04-04 GB GB13380/63A patent/GB980593A/en not_active Expired
- 1963-04-04 BE BE630572A patent/BE630572A/en unknown
- 1963-04-05 ES ES0286809A patent/ES286809A1/en not_active Expired
- 1963-04-05 ES ES286808A patent/ES286808A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BR6348190D0 (en) | 1973-07-03 |
BE630572A (en) | 1963-11-04 |
GB980593A (en) | 1965-01-13 |
ES286808A1 (en) | 1963-11-16 |
CH428741A (en) | 1967-01-31 |
ES286809A1 (en) | 1963-10-16 |
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