GB945506A - New steroid compounds and processes for their preparation - Google Patents

New steroid compounds and processes for their preparation

Info

Publication number
GB945506A
GB945506A GB1196662A GB1196662A GB945506A GB 945506 A GB945506 A GB 945506A GB 1196662 A GB1196662 A GB 1196662A GB 1196662 A GB1196662 A GB 1196662A GB 945506 A GB945506 A GB 945506A
Authority
GB
United Kingdom
Prior art keywords
bis
pregnan
hydroxymethylene
diaralkylphosphato
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1196662A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB945506A publication Critical patent/GB945506A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 20,20-bis-hydroxy-methylene -3a - phosphato -5b - pregnan -11- one having the formula: <FORM:0945506/C2/1> (where AC represents either a hydrogen atom or an acyl radical derived either from an organic carboxylic acid having from 1 to 18 carbon atoms or from a mineral acid), their non-toxic water-soluble salts, 3a -diaralkylphosphato -20,20-bis-hydroxymethylene - 5b - pregnan -11- ones and the ketonides thereof and processes for the preparation of the aforesaid compounds in which a lower ketonide of 3a -hydroxy -20,20-bis-hydroxymethylene -5b - pregnan -11- one is reacted with an aralkyl halogenophosphonate to form the corresponding ketonide of 3a -diaralkylphosphato -20,20-bis-hydroxymethylene -5b -pregnan -11- one, the protected 20,20-bis-hydroxymethylene groups of which are then liberated by acid hydrolysis to form the corresponding 3a -diaralkylphosphato -20,20-bis-hydroxymethylene -5b - pregnan -11- one, and the latter is subjected to hydro genolysis to yield 20,20-bis-hydroxymethylene -3a - phosphato -5b -pregnan -11- one. As aralkyl halogenophosphonate there may be used dibenzyl chlorophosphonate while hydrogenolysis may be effected by hydrogenation in the presence of palladium black. Specification 945,503 is referred to.
GB1196662A 1961-03-28 1962-03-28 New steroid compounds and processes for their preparation Expired GB945506A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR857054A FR1368716A (en) 1961-03-28 1961-03-28 Bis-hydroxymethyl pregnane derivatives and method of preparation

Publications (1)

Publication Number Publication Date
GB945506A true GB945506A (en) 1964-01-02

Family

ID=8751882

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1196662A Expired GB945506A (en) 1961-03-28 1962-03-28 New steroid compounds and processes for their preparation

Country Status (5)

Country Link
BE (1) BE615643A (en)
CH (1) CH406210A (en)
ES (1) ES275827A1 (en)
FR (1) FR1368716A (en)
GB (1) GB945506A (en)

Also Published As

Publication number Publication date
FR1368716A (en) 1964-08-07
ES275827A1 (en) 1962-05-16
BE615643A (en) 1962-09-27
CH406210A (en) 1966-01-31

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