ES290991A1 - Procedure for the preparation of amino steroids (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of amino steroids (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES290991A1 ES290991A1 ES290991A ES290991A ES290991A1 ES 290991 A1 ES290991 A1 ES 290991A1 ES 290991 A ES290991 A ES 290991A ES 290991 A ES290991 A ES 290991A ES 290991 A1 ES290991 A1 ES 290991A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- alkyl
- functions
- double bond
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Preparation process, of the amino-steroids of the general formula; ** (See formula) ** wherein R and R1 represent lower alkyl, aryl or aralkyl radicals, R2 represents tm alkyl radical having from 1 to 4 carbon atoms, (see formula), being OR3 of alpha or beta configuration and designating R3 hydrogen or a substituted lower acyl radical or not, Y = H2 0 (see formula) the hydroxyl being in alpha or in beta, these compounds can be saturated and belong to the series 5alfa, or 5beta-pregnanes or can even be unsaturated and have a double bond that starts from carbon 4, or a system of two double bonds in positions 1 and 4, as well as the salts of these compounds, characterized in that a primary omin of formula NH2R is reacted on a 20-oxo asteroid of the pragnano series, in which the other functions are previously protected Existing ketone in the form of a cyclic ketal, the resulting 20-imino derivative is transformed into the ternary imino salt by treatment with a lower alkyl, aryl or aralkyl halide of the formula hal.R1 (a halogen being halo), the salt obtained is reacted with an alkyl magnesium halide of the formula Hal.HgR2, a 20-alkyl-20-amino steroid is obtained from which the ketone functions are released by hydrolysis, and/or the functions are transformed sn 3 and/or 11 by reduction or oxidation, an existing double bond in position 5,5 is possibly reduced and/or a double bond in position 4,5 is introduced, or a system of two double bonds in position 1,2 and 4,5, and/or arrived at the case the hydroxyl function is acylated at 3 or the resulting compound is eventually converted to a salt of a mineral or organic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR907856A FR1421231A (en) | 1962-08-27 | 1962-08-27 | New amino steroids and method of preparation |
FR933624A FR56F (en) | 1962-08-27 | 1963-05-03 | New drug in particular for the treatment of spasms of coronary or vascular origin. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES290991A1 true ES290991A1 (en) | 1963-12-01 |
Family
ID=8785774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES290991A Expired ES290991A1 (en) | 1962-08-27 | 1963-08-22 | Procedure for the preparation of amino steroids (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE636641A (en) |
DE (4) | DE1212082B (en) |
ES (1) | ES290991A1 (en) |
FR (3) | FR1421231A (en) |
GB (4) | GB1025906A (en) |
NL (4) | NL297133A (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3013008A (en) * | 1961-01-09 | 1961-12-12 | Searle & Co | N-substituted 20-aminopregnan-3-ols, esters thereof, and deta-derivatives corresponding |
-
0
- NL NL297135D patent/NL297135A/xx unknown
- BE BE636641D patent/BE636641A/xx unknown
- NL NL297131D patent/NL297131A/xx unknown
- NL NL123751D patent/NL123751C/xx active
- NL NL297133D patent/NL297133A/xx unknown
-
1962
- 1962-08-27 FR FR907856A patent/FR1421231A/en not_active Expired
- 1962-11-27 FR FR916749A patent/FR2374M/en not_active Expired
-
1963
- 1963-05-03 FR FR933624A patent/FR56F/en not_active Expired
- 1963-08-22 ES ES290991A patent/ES290991A1/en not_active Expired
- 1963-08-27 DE DER35992A patent/DE1212082B/en active Pending
- 1963-08-27 GB GB3393663A patent/GB1025906A/en not_active Expired
- 1963-08-27 DE DER35990A patent/DE1212080B/en active Pending
- 1963-08-27 GB GB3393863A patent/GB1025908A/en not_active Expired
- 1963-08-27 DE DER35993A patent/DE1212083B/en active Pending
- 1963-08-27 DE DER35991A patent/DE1212081B/en active Pending
- 1963-08-27 GB GB3393763A patent/GB1025907A/en not_active Expired
-
1965
- 1965-04-14 GB GB1601065A patent/GB1045644A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL297133A (en) | |
GB1025906A (en) | 1966-04-14 |
BE636641A (en) | |
DE1212081B (en) | 1966-03-10 |
FR2374M (en) | 1964-04-03 |
NL297131A (en) | |
FR1421231A (en) | 1965-12-17 |
GB1025907A (en) | 1966-04-14 |
NL123751C (en) | |
DE1212083B (en) | 1966-03-10 |
DE1212082B (en) | 1966-03-10 |
FR56F (en) | 1964-10-16 |
GB1025908A (en) | 1966-04-14 |
GB1045644A (en) | 1966-10-12 |
NL297135A (en) | |
DE1212080B (en) | 1966-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES300814A1 (en) | A procedure for the preparation of steroid compounds (Machine-translation by Google Translate, not legally binding) | |
GB1048231A (en) | New steroid compounds, compositions incorporating them and processes for their preparation | |
ES299652A1 (en) | A procedure for the preparation of steroid compounds (Machine-translation by Google Translate, not legally binding) | |
ES290991A1 (en) | Procedure for the preparation of amino steroids (Machine-translation by Google Translate, not legally binding) | |
ES317157A1 (en) | A method of preparing a compound derived from phenoxyactic and phenyltioactic acids. (Machine-translation by Google Translate, not legally binding) | |
ES417737A1 (en) | Steroids of the pregnane series | |
GB957953A (en) | Steroids and their production | |
ES317454A1 (en) | Procedure for the preparation of amidas of derivatives of lysergic acid. (Machine-translation by Google Translate, not legally binding) | |
GB977227A (en) | Acyl-propiolic acid esters and process for their manufacture | |
ES438695A1 (en) | A procedure for the preparation of prostate acid derivatives. (Machine-translation by Google Translate, not legally binding) | |
GB1028154A (en) | Substituted pregnenes, pregnadienes and methods of preparing the same | |
GB983628A (en) | New 3-phenyl-granatene-(2) derivatives | |
GB1101117A (en) | Steroidal 2ª-carbonylhydrazones | |
ES389536A1 (en) | Procedure for the preparation of benzofuran derivatives. (Machine-translation by Google Translate, not legally binding) | |
ES332858A1 (en) | Procedure for the preparation of new azines. (Machine-translation by Google Translate, not legally binding) | |
ES325366A1 (en) | Procedure for the production of derivatives of isoquinoline. (Machine-translation by Google Translate, not legally binding) | |
GB1056936A (en) | Novel pregnane compounds and processes for their preparation | |
ES394036A1 (en) | 17alpha-hydroxy and acyloxy substituted-9alpha-methyl-19-norprogesterones | |
ES287028A1 (en) | Procedure for the manufacture of new basic derivatives of fenoxazine and its salts (Machine-translation by Google Translate, not legally binding) | |
ES423018A3 (en) | Method for the preparation of steroid compounds. (Machine-translation by Google Translate, not legally binding) | |
ES290324A1 (en) | Procedure for the obtaining of new esteroid phosphoric esters (Machine-translation by Google Translate, not legally binding) | |
GB1110725A (en) | Process for preparing cyloheptimidazolinium halides | |
ES320083A1 (en) | Procedure for the preparation of derivatives of difenylamine. (Machine-translation by Google Translate, not legally binding) | |
ES302362A1 (en) | Procedure for the production of heterocyclic compounds (Machine-translation by Google Translate, not legally binding) | |
ES310875A1 (en) | A procedure for the preparation of new nitrogenated steroids. (Machine-translation by Google Translate, not legally binding) |