GB944638A - New salts of 1,5-bis(4-amidinophenoxy)-pentane - Google Patents
New salts of 1,5-bis(4-amidinophenoxy)-pentaneInfo
- Publication number
- GB944638A GB944638A GB4774/62A GB477462A GB944638A GB 944638 A GB944638 A GB 944638A GB 4774/62 A GB4774/62 A GB 4774/62A GB 477462 A GB477462 A GB 477462A GB 944638 A GB944638 A GB 944638A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amidinophenoxy
- pentane
- bis
- salt
- melaminylphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical class C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- 239000002270 dispersing agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 abstract 1
- 229940093471 ethyl oleate Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000012457 nonaqueous media Substances 0.000 abstract 1
- 235000008390 olive oil Nutrition 0.000 abstract 1
- 239000004006 olive oil Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000000654 trypanocidal effect Effects 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises the meso and racemic forms (forms A and B respectively) of 1, 5-bis (4-amidinophenoxy) - pentane 2 - (4 - melaminylphenyl)-1, 3, 2-dithioarsolane dicarboxylates of formula: <FORM:0944638/C2/1> They may be prepared by reacting in a liquid medium (preferably water) a salt of 2-(4-melaminylphenyl) - 4, 5 - dicarboxy - 1, 3, 2-dithioarsolane form A or form B (e.g. an alkali metal salt) and a salt of 1, 5-bis (4-amidinophenoxy) pentane, or by reacting the free compounds with each other in an organic solvent such as dimethylsulphoxide. The above compounds possess chemotherapeutic properties and may be used as trypanocidal preparations together with a pharmaceutical carrier. Parenteral preparations may be made as sterile aqueous or non-aqueous solutions, suspensions or emulsions. Specified carrier media include propylene glycol, polyethylene glycol, vegetable oils such as olive oil and injectable esters such as ethyl oleate. Other adjuvants such as wetting, emulsifying and dispersing agents may be present.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR852056A FR1383717A (en) | 1961-02-08 | 1961-02-08 | New salts of bis (amidino-4'-phenoxy) -1, 5 pentane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB944638A true GB944638A (en) | 1963-12-18 |
Family
ID=8748383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4774/62A Expired GB944638A (en) | 1961-02-08 | 1962-02-07 | New salts of 1,5-bis(4-amidinophenoxy)-pentane |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH405333A (en) |
| FR (2) | FR1383717A (en) |
| GB (1) | GB944638A (en) |
-
1961
- 1961-02-08 FR FR852056A patent/FR1383717A/en not_active Expired
- 1961-12-19 FR FR882433A patent/FR1894M/en not_active Expired
-
1962
- 1962-02-01 CH CH131362A patent/CH405333A/en unknown
- 1962-02-07 GB GB4774/62A patent/GB944638A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1383717A (en) | 1965-01-04 |
| CH405333A (en) | 1966-01-15 |
| FR1894M (en) | 1963-07-08 |
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