GB919434A - New steroid compounds, and processes for their preparation - Google Patents

New steroid compounds, and processes for their preparation

Info

Publication number
GB919434A
GB919434A GB3860161A GB3860161A GB919434A GB 919434 A GB919434 A GB 919434A GB 3860161 A GB3860161 A GB 3860161A GB 3860161 A GB3860161 A GB 3860161A GB 919434 A GB919434 A GB 919434A
Authority
GB
United Kingdom
Prior art keywords
estra
hydroxy
preparation
processes
steroid compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3860161A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB919434A publication Critical patent/GB919434A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 17a -ethinyl-17b hydroxy - estra - b (10),9(11) - dien-3-one and a process for the preparation thereof by reacting 17a - ethynyl - 17b - hydroxy-estra-4,9(10)-dien3-one with a secondary amine so as to form the corresponding 3-enamino-17a -ethynyl-17b hydroxy - estra - 3,5(10),9(11) - triene of the formula: <FORM:0919434/IV (b)/1> (where R and R1 are alkyl groups, which may be the same or different, or together with the nitrogen atom constitute a heterocyclic ring containing nitrogen or both nitrogen and oxygen) and the latter is subjected to hydrolysis in an acid medium so as to yield the desired 17a -ethinyl-17b -hydroxy-estra-5(10), 9(11)-dien-3-one. As secondary amine there may be used pyrrolidine, piperidine or morpholine. Hydrolysis may be effected with formic or acetic acids.
GB3860161A 1960-11-04 1961-10-27 New steroid compounds, and processes for their preparation Expired GB919434A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR843044A FR1363115A (en) 1960-11-04 1960-11-04 Novel ethynylated steroid derivative and method of preparation

Publications (1)

Publication Number Publication Date
GB919434A true GB919434A (en) 1963-02-27

Family

ID=8742086

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3860161A Expired GB919434A (en) 1960-11-04 1961-10-27 New steroid compounds, and processes for their preparation

Country Status (5)

Country Link
BE (1) BE609881A (en)
CH (1) CH395979A (en)
ES (1) ES271722A1 (en)
FR (1) FR1363115A (en)
GB (1) GB919434A (en)

Also Published As

Publication number Publication date
ES271722A1 (en) 1962-01-01
CH395979A (en) 1965-07-31
BE609881A (en) 1962-05-03
FR1363115A (en) 1964-06-12

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