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Expired
Application number
GB1252/56A
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Sandoz AG
Original Assignee
Sandoz AG
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Publication date
Application filed by Sandoz AGfiledCriticalSandoz AG
Publication of GB785173ApublicationCriticalpatent/GB785173A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The invention comprises amide-like lysergic and isolysergic acid derivatives of the general formula <FORM:0785173/IV (a)/1> wherein R represents <FORM:0785173/IV (a)/2> and their salts with acids, and the preparation thereof by reacting isolysergic acid azide in solution with pyrrolidine, piperidine, pyrroline or morpholine and separating the lysergic and isolysergic acid amides from the resulting mixture thereof (e.g. by chromatography on aluminium oxide). The reaction is preferably effected at a temperature of from room temperature to 70 DEG C., suitable solvents being inert organic liquids or excess of the amine used in the reaction. The products are pharmaceutically useful. Examples describe the preparation of compounds corresponding to each of the meanings given above for R. The dimaleates of lysergic acid pyrrolidide, morpholide and pyrrolinide and the D-tartrate of lysergic acid piperidide and morpholide are described.
GB1252/56A1955-01-211956-01-13Amide-like derivatives of lysergic and isolysergic acids
ExpiredGB785173A
(en)
Procedure for the obtaining of amidas from the acid 1,6-dimetildelta-8,9-ergolen-8-carboxilico. (Machine-translation by Google Translate, not legally binding)