GB785173A - Amide-like derivatives of lysergic and isolysergic acids - Google Patents

Amide-like derivatives of lysergic and isolysergic acids

Info

Publication number
GB785173A
GB785173A GB1252/56A GB125256A GB785173A GB 785173 A GB785173 A GB 785173A GB 1252/56 A GB1252/56 A GB 1252/56A GB 125256 A GB125256 A GB 125256A GB 785173 A GB785173 A GB 785173A
Authority
GB
United Kingdom
Prior art keywords
lysergic
isolysergic
acid
morpholide
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1252/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB785173A publication Critical patent/GB785173A/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises amide-like lysergic and isolysergic acid derivatives of the general formula <FORM:0785173/IV (a)/1> wherein R represents <FORM:0785173/IV (a)/2> and their salts with acids, and the preparation thereof by reacting isolysergic acid azide in solution with pyrrolidine, piperidine, pyrroline or morpholine and separating the lysergic and isolysergic acid amides from the resulting mixture thereof (e.g. by chromatography on aluminium oxide). The reaction is preferably effected at a temperature of from room temperature to 70 DEG C., suitable solvents being inert organic liquids or excess of the amine used in the reaction. The products are pharmaceutically useful. Examples describe the preparation of compounds corresponding to each of the meanings given above for R. The dimaleates of lysergic acid pyrrolidide, morpholide and pyrrolinide and the D-tartrate of lysergic acid piperidide and morpholide are described.
GB1252/56A 1955-01-21 1956-01-13 Amide-like derivatives of lysergic and isolysergic acids Expired GB785173A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH785173X 1955-01-21

Publications (1)

Publication Number Publication Date
GB785173A true GB785173A (en) 1957-10-23

Family

ID=4536526

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1252/56A Expired GB785173A (en) 1955-01-21 1956-01-13 Amide-like derivatives of lysergic and isolysergic acids

Country Status (1)

Country Link
GB (1) GB785173A (en)

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