GB895090A - Improvements relating to quinaldinium derivatives and their preparation - Google Patents
Improvements relating to quinaldinium derivatives and their preparationInfo
- Publication number
- GB895090A GB895090A GB22237/60A GB2223760A GB895090A GB 895090 A GB895090 A GB 895090A GB 22237/60 A GB22237/60 A GB 22237/60A GB 2223760 A GB2223760 A GB 2223760A GB 895090 A GB895090 A GB 895090A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- formula
- quinaldinium
- alkylene
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises N4, N41-alkylene-N1,N11 - alkelene - bis - 4 - amino - quinaldinium dihalides of the general formula <FORM:0895090/IV (b)/1> wherein R represents a straight or branched chain alkylene radical having 4 to 12 carbon atoms (or, in the case of a branched chain radical, in the main chain), R1 represents hydrogen or an alkyl radical having 1 to 5, n represents a whole number from 4 to 12, and X represents a halogen, and the preparation thereof by reacting a 4-aminoquinaldine of the formula <FORM:0895090/IV (b)/2> with a dihaloalkane of the formula X-R-X, wherein X represents a halogen and R has the above significance, to form the corresponding N4,N41 - alkylene - bis - 4 - aminoquinaldine, and reacting the said quinaldine with a dihaloalkane of the formula X-(CH2)n-X, wherein n and X have the above significance, by reacting the corresponding N1,N11 - alkylene - bis - 4 - amino - quinaldinium dihalide with a dihaloalkane of the formula X-R-X, wherein X and R have the above significance, and by reacting a 4-haloquinaldinium halide with a diaminoalkane of the formula R1-NH-R-NH-R1, wherein R1 and R have the above significance, and reacting the resulting N4,N41-bis-quinaldinium compound with a dihaloalkane of the formula X-(CH2)n-X, wherein X and n have the above significance. In the examples the following compounds are prepared: N4,N41-decamethylene-N1,N11 - decamethylene - bis - 4 - aminoquinaldinium dibromide and diiodide and the corresponding intermediate compounds N1,N11 - decamethylene - bis - 4 - aminoquinaldinium dibromide and diiodide and the corresponding intermediate compounds N1,N11-decamethylene-bis-4-aminoquinaldinium dibromide and dichloride, and N1,N11 - tetramethylene - N4,N41 - tetramethylene - N4,N41 - diethyl - bis(4 - amino - quinaldinium iodide) and the corresponding intermediate compound N,N1 - bis - (2 - methylquinolyl - (4) -) - N, N1 - (diethyl) - 1,4 - diaminobutane. A therapeutic composition having anti-bacterial activity contains as the active ingredient an N4,N41 - alkylene - N1,N11 - alkylene - bis - 4 - amino - quinaldinium dihalide of the first general formula above. The composition may be in the form of a cream, liquid or pastille.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE895090X | 1959-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB895090A true GB895090A (en) | 1962-05-02 |
Family
ID=6847533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22237/60A Expired GB895090A (en) | 1959-06-26 | 1960-06-24 | Improvements relating to quinaldinium derivatives and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB895090A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997048705A1 (en) * | 1996-06-19 | 1997-12-24 | University College London | Potassium channel blockers |
| WO2013098837A2 (en) | 2011-10-24 | 2013-07-04 | Keki Hormusji Gharda | A bis-quinaldine compound and a process for preparing the same |
-
1960
- 1960-06-24 GB GB22237/60A patent/GB895090A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997048705A1 (en) * | 1996-06-19 | 1997-12-24 | University College London | Potassium channel blockers |
| WO2013098837A2 (en) | 2011-10-24 | 2013-07-04 | Keki Hormusji Gharda | A bis-quinaldine compound and a process for preparing the same |
| US9062000B2 (en) | 2011-10-24 | 2015-06-23 | Keki Hormusji Gharda | Bis-quinaldine compound and a process for preparing the same |
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