GB890207A - Extraction of a new polysaccharide substance from crude fucoidin - Google Patents
Extraction of a new polysaccharide substance from crude fucoidinInfo
- Publication number
- GB890207A GB890207A GB7482/58A GB748258A GB890207A GB 890207 A GB890207 A GB 890207A GB 7482/58 A GB7482/58 A GB 7482/58A GB 748258 A GB748258 A GB 748258A GB 890207 A GB890207 A GB 890207A
- Authority
- GB
- United Kingdom
- Prior art keywords
- polysaccharide
- water
- fucoidin
- crude
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0036—Galactans; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Alternative & Traditional Medicine (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises a polysaccharide comprising a fucosemethylpentose ether sulphate polymer having a molecular weight of about 5,000 to about 50,000, a specific rotation of [a ]25D = -119,6 DEG in water, having in aqueous solution of 0,8% strength an ultra-violet absorption of very weak character in the range 256-280mm and being devoid of additional absorption maxima at 220-600 mm , having in 0,85 saline solution a relative viscosity of 1,2 being amorphous in character, containing the elements carbon, hydrogen, oxygen, sulphur, sodium, potassium and calcium, and being soluble in water. The novel polysaccharide is obtained by fractional precipitation of an aqueous solution of crude fucoidin by means of a water-miscible organic solvent and collecting the polysaccharide precipitated as the concentration of the solvent in the solution is increased from about 45% to about 67%, or by treating the said aqueous solution with a quaternary ammonium compound, preferably one containing a carbon chain of 8 carbon atoms or more, collecting the water-insoluble precipitate, breaking up the obtained quaternary ammonium-polysaccharide complex by the addition of a strongly ionizable salt and collecting the polysaccharide from the obtained solution with a water-miscible organic solvent. Both the fractional precipitation method and the quaternary ammonium complex formation may be used. The new polysaccharide may be further purified by dialysis. The product possesses anticoagulant and antilipemic activity. An example also describes the extraction of crude fucoidin from ground, air-dried Fucus vesiculosus by heating with water, adding toluene, diluting and filtering the supernatant fluid, adding lead acetate solution and filtering, adding barium hydroxide to the filtrate, shaking the resultant precipitate with sulphuric acid, and dialysing for 3 days. The non-dialysable material is concentrated in vacuo, freed of insoluble material by spinning at 12,000 g. for 45 minutes, the supernatant is poured into ethanol and dried in vacuo over P2O5. The material is designated as crude fucoidin.ALSO:A new polysaccharide comprising a fucosemethylpentose ether sulphate polymer (obtained from crude fucoidin, see Group IV (a)) having anticoagulant and antilipemic properties, may be dispersed in any of the usual dosage unit forms of pharmaceutical preparations, for example, tablets, pills, capsules, solutions, powders, with any desired excipients, binders, fillers or other therapeutically inert ingredients. For parenteral administration, the polysaccharide may be dissolved in any suitable liquid medium which is compatible with body fluids, e.g. physiological saline solution. For oral administration, the polysaccharide may be employed with or without other physiological active ingredients in tablets, pills or capsules.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US890207XA | 1957-03-07 | 1957-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB890207A true GB890207A (en) | 1962-02-28 |
Family
ID=22215011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7482/58A Expired GB890207A (en) | 1957-03-07 | 1958-03-07 | Extraction of a new polysaccharide substance from crude fucoidin |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB890207A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0403377A1 (en) * | 1989-06-14 | 1990-12-19 | Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer) | Sulfated polysaccharides, anticoagulant and anticomplementary agent prepared from fucans from brown seaweeds and process for obtaining them |
EP1008306A2 (en) * | 1998-12-10 | 2000-06-14 | Nissin Shokuhin Kabushiki Kaisha | Polysaccharide which can reduce viscosity resulting from psyllium, and foods containing the polysaccharide and psyllium |
US6682770B2 (en) | 1998-12-10 | 2004-01-27 | Nissin Shokuhin Kabushiki Kaisha | Polysaccharide capable of reducing the viscosity of a hydrated psyllium, and foods containing the polysaccharide and psyllium |
FR2881051A1 (en) * | 2005-01-27 | 2006-07-28 | Therapol Sa | Using fucans from Pheophyceae for preparation of bacteriophobic and bacteriostatic materials, particularly for impregnation of contact lenses, also to inhibit the complement system |
-
1958
- 1958-03-07 GB GB7482/58A patent/GB890207A/en not_active Expired
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0403377A1 (en) * | 1989-06-14 | 1990-12-19 | Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer) | Sulfated polysaccharides, anticoagulant and anticomplementary agent prepared from fucans from brown seaweeds and process for obtaining them |
FR2648463A1 (en) * | 1989-06-14 | 1990-12-21 | Inst Fs Rech Expl Mer | SULFATED POLYSACCHARIDES, ANTICOAGULANT AGENT AND ANTICOMPLEMENTARY AGENT OBTAINED FROM FUCANS OF BROWN ALGAE AND METHOD OF OBTAINING SAME |
WO1990015823A1 (en) * | 1989-06-14 | 1990-12-27 | Institut Français De Recherche Pour L'exploitation De La Mer | Sulphated polysaccharides, anticoagulant agent and anticomplementary agent obtained from brown algae fucuses and method of obtaining same |
US5321133A (en) * | 1989-06-14 | 1994-06-14 | Institut Francais De Recherche Pour L'exploitation De La Mer-Ifremer | Sulphated polysaccharides, anticoagulant agent and anticomplementary agent obtained from brown algae fucuses and method of obtaining same |
EP1008306A2 (en) * | 1998-12-10 | 2000-06-14 | Nissin Shokuhin Kabushiki Kaisha | Polysaccharide which can reduce viscosity resulting from psyllium, and foods containing the polysaccharide and psyllium |
EP1008306A3 (en) * | 1998-12-10 | 2001-04-18 | Nissin Shokuhin Kabushiki Kaisha | Polysaccharide which can reduce viscosity resulting from psyllium, and foods containing the polysaccharide and psyllium |
US6682770B2 (en) | 1998-12-10 | 2004-01-27 | Nissin Shokuhin Kabushiki Kaisha | Polysaccharide capable of reducing the viscosity of a hydrated psyllium, and foods containing the polysaccharide and psyllium |
FR2881051A1 (en) * | 2005-01-27 | 2006-07-28 | Therapol Sa | Using fucans from Pheophyceae for preparation of bacteriophobic and bacteriostatic materials, particularly for impregnation of contact lenses, also to inhibit the complement system |
WO2006079698A1 (en) * | 2005-01-27 | 2006-08-03 | Therapol | Use of fucans for preparing a bacteriophobic and bacteriostatic material, corresponding material and applications |
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