GB8814598D0 - New cyclosporin derivatives with modified"8-amino acid" - Google Patents

New cyclosporin derivatives with modified"8-amino acid"

Info

Publication number
GB8814598D0
GB8814598D0 GB888814598A GB8814598A GB8814598D0 GB 8814598 D0 GB8814598 D0 GB 8814598D0 GB 888814598 A GB888814598 A GB 888814598A GB 8814598 A GB8814598 A GB 8814598A GB 8814598 D0 GB8814598 D0 GB 8814598D0
Authority
GB
United Kingdom
Prior art keywords
modified
amino acid
cyclosporin derivatives
new cyclosporin
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB888814598A
Other versions
GB2206119A (en
GB2206119B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB8814598D0 publication Critical patent/GB8814598D0/en
Publication of GB2206119A publication Critical patent/GB2206119A/en
Application granted granted Critical
Publication of GB2206119B publication Critical patent/GB2206119B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
GB8814598A 1987-06-22 1988-06-20 A new cyclosporin derivative with modified "8-amino acid" Expired - Fee Related GB2206119B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6467487A 1987-06-22 1987-06-22

Publications (3)

Publication Number Publication Date
GB8814598D0 true GB8814598D0 (en) 1988-07-27
GB2206119A GB2206119A (en) 1988-12-29
GB2206119B GB2206119B (en) 1990-10-31

Family

ID=22057543

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8814598A Expired - Fee Related GB2206119B (en) 1987-06-22 1988-06-20 A new cyclosporin derivative with modified "8-amino acid"

Country Status (2)

Country Link
CA (1) CA1338319C (en)
GB (1) GB2206119B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3888357T2 (en) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin derivatives that carry a modified amino acid at position 8.
CH679119A5 (en) * 1988-05-13 1991-12-31 Sandoz Ag
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GB2227244A (en) * 1989-01-19 1990-07-25 Merck & Co Inc Immunosuppressive fluorinated cyclosporin analogs
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
DK0589843T3 (en) 1992-09-25 2002-04-02 Novartis Ag Cyclosporin-containing pharmaceutical preparations
JPH08509368A (en) * 1993-04-23 1996-10-08 サンド・リミテッド GAPDH from recombinant alanine racemase and Trypocladium niveum
DE59510233D1 (en) 1994-11-03 2002-07-11 Novartis Ag NEW PREPARATION FORMS OF CYCLOSPORINE FOR ORAL APPLICATION WITH SIMPLE COMPOSITION AND HIGH BIOVAVAILABILITY AND METHOD FOR THE PRODUCTION THEREOF
DE19549852B4 (en) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin containing preparations
EP0988046B1 (en) 1997-01-30 2004-09-15 Novartis AG Oil-free pharmaceutical compositions containing cyclosporin a
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
PL210795B1 (en) 2001-10-19 2012-03-30 Isotechnika Inc The method of producing the ISATX247 enriched isomer (E), the method of producing the ISATX247 enriched mixture of the (Z) isomer, the method of stereoselective synthesis of the (E) ISATX247 isomer, the method of stereoselective synthesis of the (Z) isomer ISATX247 and the method of producing the mixture of ISATX247 isomers
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2010088573A1 (en) 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2012145427A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
AU2014311346A1 (en) 2013-08-26 2016-03-17 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins

Also Published As

Publication number Publication date
CA1338319C (en) 1996-05-07
GB2206119A (en) 1988-12-29
GB2206119B (en) 1990-10-31

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20020620