GB872129A - Process for the production of 3ª-, 12ª--dihydroxy-11-oxo-23-bromospirostane - Google Patents
Process for the production of 3ª-, 12ª--dihydroxy-11-oxo-23-bromospirostaneInfo
- Publication number
- GB872129A GB872129A GB7978/60A GB797860A GB872129A GB 872129 A GB872129 A GB 872129A GB 7978/60 A GB7978/60 A GB 7978/60A GB 797860 A GB797860 A GB 797860A GB 872129 A GB872129 A GB 872129A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxo
- bromospirostane
- dihydroxy
- diacetoxy
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 3b ,11 a -diacetoxy-12-oxo-23-bromospirostane and a process for the preparation of 3b ,12b -dihydroxy-11-oxo-23-bromospirostane by reacting 11b ,23-dibromohecogenin acetate with an alkali metal acetate in an organic solvent at a temperature between 50 DEG and 155 DEG C., separating the sparingly soluble impurities from the resulting mixture of 3b ,11(a and b )-diacetoxy-12-oxo-23-bromospirostanes (the 11a isomer predominates), and hydrolysing the compounds of the mixture by heating with aqueous or aqueous-alcoholic alkali. The organic solvent may be alcohol or a solvent in which the alkali metal acetate is soluble such as t-butanol or dimethyl formamide. p Detailed examples are given. Specification 721,953 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEB52366A DE1092913B (en) | 1959-03-05 | 1959-03-05 | Process for the preparation of 3,12-dioxy-11-oxo-23-bromo-spirostane |
Publications (1)
Publication Number | Publication Date |
---|---|
GB872129A true GB872129A (en) | 1961-07-05 |
Family
ID=6969880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7978/60A Expired GB872129A (en) | 1959-03-05 | 1960-03-07 | Process for the production of 3ª-, 12ª--dihydroxy-11-oxo-23-bromospirostane |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH377809A (en) |
DE (1) | DE1092913B (en) |
GB (1) | GB872129A (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE965326C (en) * | 1954-04-30 | 1957-06-06 | G N R D Patent Holdings Ltd | Process for the preparation of 23-bromo-5ª ‡, 22-a-spirostan-3ª ‰, 12ª ‰ -diol-11-one |
-
1959
- 1959-03-05 DE DEB52366A patent/DE1092913B/en active Pending
-
1960
- 1960-03-03 CH CH240160A patent/CH377809A/en unknown
- 1960-03-07 GB GB7978/60A patent/GB872129A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH377809A (en) | 1964-05-31 |
DE1092913B (en) | 1960-11-17 |
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