GB833595A - An improvement in the fermentative preparation of prednisolone - Google Patents

An improvement in the fermentative preparation of prednisolone

Info

Publication number
GB833595A
GB833595A GB32377/57A GB3237757A GB833595A GB 833595 A GB833595 A GB 833595A GB 32377/57 A GB32377/57 A GB 32377/57A GB 3237757 A GB3237757 A GB 3237757A GB 833595 A GB833595 A GB 833595A
Authority
GB
United Kingdom
Prior art keywords
cortisol
culture
crystals
prednisolone
improvement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32377/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB833595A publication Critical patent/GB833595A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

D 1-Cortisol is prepared by adding solid cortisol to a culture of the micro-organism Corynebacterium simplex and fermenting the culture under aerobic conditions. From 1 gram to 400 grams of cortisol may be used per litre of culture solution. The progress and completion of the fermentation process may be determined by observing microscopically the decrease of crystals of short pillar or plate form (cortisol) and the increase of crystals of needle or long pillar form (D 1-cortisol) in the fermented broth. The D 1-cortisol may be separated by recrystallization of the solid ingredients from an organic solvent such as methanol or acetone. Detailed examples are given.
GB32377/57A 1956-10-17 1957-10-16 An improvement in the fermentative preparation of prednisolone Expired GB833595A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP833595X 1956-10-17

Publications (1)

Publication Number Publication Date
GB833595A true GB833595A (en) 1960-04-27

Family

ID=13800219

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32377/57A Expired GB833595A (en) 1956-10-17 1957-10-16 An improvement in the fermentative preparation of prednisolone

Country Status (1)

Country Link
GB (1) GB833595A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493095B1 (en) * 1964-09-23 1970-06-18 Farmaceutici Italia Process for the production of 3-keto-delta? -Steroids of the androstane or pregnane series

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493095B1 (en) * 1964-09-23 1970-06-18 Farmaceutici Italia Process for the production of 3-keto-delta? -Steroids of the androstane or pregnane series

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