GB827548A - Chloro-oleandomycin and acid salts thereof - Google Patents
Chloro-oleandomycin and acid salts thereofInfo
- Publication number
- GB827548A GB827548A GB36063/56A GB3606356A GB827548A GB 827548 A GB827548 A GB 827548A GB 36063/56 A GB36063/56 A GB 36063/56A GB 3606356 A GB3606356 A GB 3606356A GB 827548 A GB827548 A GB 827548A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oleandomycin
- chloro
- salts
- phosphate
- methyl isobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Chloro-oleandomycin active against Grampositive micro-organisms and particularly Listeria monocytogenes is prepared by treating the antibiotic oleandomycin with anhydrous hydrogen chloride in an anhydrous organic solvent. Chloro-oleandomycin is separated from unchanged oleandomycin by countercurrent distribution using a solvent system consisting of methyl isobutyl ketone acetone and a phosphate citrate buffer of pH 7.0. Chloro-oleandomycin is recovered from the methyl isobutyl ketone layer. Salts with inorganic and organic acids containing from one to twelve carbon atoms are prepared by adding the appropriate acid, especially under anhydrous conditions, to the above chloro-oleandomycin solution. Specified salts are the mineral acid salts such as the hydrochloride, nitrate and phosphate, and the salts with formic, acetic, butyric, lauric, benzoic, p-nitro benzoic and naphthoic acids. Suitable anhydrous organic solvents are propanol, isopropanol, acetone, methyl ethyl ketone, di-isopropyl ketone, methyl isobutyl ketone, ethyl acetate and propyl acetate. The physical characteristics of chloro-oleandomycin hydrochloride, nitrate and phosphate are described. Specification 779,257 is referred to.ALSO:The antibiotic chloro-oleandomycin (see Group IV (b)) is used orally in aqueous solution or in admixture with the animals food, for the treatment of Listeriosis in animals. Specification 779,257 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US827548XA | 1956-01-30 | 1956-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB827548A true GB827548A (en) | 1960-02-10 |
Family
ID=22173235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36063/56A Expired GB827548A (en) | 1956-01-30 | 1956-11-26 | Chloro-oleandomycin and acid salts thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB827548A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276956A (en) * | 1963-05-31 | 1966-10-04 | Abbott Lab | Treating infections in poultry caused by pleuropneumoniia-like organisms with erythromycin phosphate |
-
1956
- 1956-11-26 GB GB36063/56A patent/GB827548A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276956A (en) * | 1963-05-31 | 1966-10-04 | Abbott Lab | Treating infections in poultry caused by pleuropneumoniia-like organisms with erythromycin phosphate |
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