GB803149A - Improvements in or relating to the preparation of thyroxine analogues - Google Patents
Improvements in or relating to the preparation of thyroxine analoguesInfo
- Publication number
- GB803149A GB803149A GB1430056A GB1430056A GB803149A GB 803149 A GB803149 A GB 803149A GB 1430056 A GB1430056 A GB 1430056A GB 1430056 A GB1430056 A GB 1430056A GB 803149 A GB803149 A GB 803149A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparation
- iodine
- contain
- reaction
- organic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the general formula: <FORM:0803149/IV (b)/1> wherein Y is H or I and Y1 is I, and esters and salts thereof, are obtained by treating a compound of the formula: <FORM:0803149/IV (b)/2> or an ester or salt thereof, with iodine in a suitable solvent and in the presence of a suitable organic base. As solvent there may be used water, dioxan or a lower aliphatic alcohol, e.g. methanol or ethanol. As organic base there may be used a primary or secondary amine which may contain a cyclohexyl or alkylcyclohexyl group and which may contain one or two hydroxy groups, piperidine, a C-alkyl piperidine or morpholine, the base in every case having not more than eight carbon atoms, e.g. methylamine, ethylamine, butylamine, ethylene diamine, dimethylamine, dibutylamine, monoethanolamine and diethanolamine. Preferably the reaction is effected at from 0-30 DEG C. By carrying out the reaction in the presence of hydrogen peroxide only half the normal quantity of iodine is required. Examples disclose the preparation of 3,5,31-triiodo-4-(41-hydroxy-phenoxy) phenyl acetic acid and of 3,5,31,51-tetraiodo - 4 - (41 - hydroxyphenoxy) phenylacetic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1430056A GB803149A (en) | 1956-05-08 | 1956-05-08 | Improvements in or relating to the preparation of thyroxine analogues |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1430056A GB803149A (en) | 1956-05-08 | 1956-05-08 | Improvements in or relating to the preparation of thyroxine analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB803149A true GB803149A (en) | 1958-10-22 |
Family
ID=10038679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1430056A Expired GB803149A (en) | 1956-05-08 | 1956-05-08 | Improvements in or relating to the preparation of thyroxine analogues |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB803149A (en) |
-
1956
- 1956-05-08 GB GB1430056A patent/GB803149A/en not_active Expired
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