GB791180A - Improvements in or relating to methods of producing dry stable vitamin a and/or d preparations - Google Patents

Abstract

Products containing vitamin A and/or vitamin D which are stable in admixture with mineral preparations and mixtures of mineral preparations and protein concentrates are made by adding to a vitamin A and/or vitamin D material at least 2g. of 4-methyl-2,6-ditertiary-butylphenol per 100 Standard Units of vitamin A and/or vitamin D, dispersing this mixture in liquid or molten state in an aqueous liquid containing a jellifiable, film-forming colloid, and converting the dispersion to small, dry particles, e.g., by dispersing the dispersion in warm castor oil or paraffin oil, cooling to produce particles, and dissolving off the oil by hexane, acetone, ethanol, isopropanol, methyl ethyl ketone or n-propanol, or by spraying the dispersion into a hot chamber. The colloids are exemplified by gelatine, blood albumen, lactalbumin, carboxymethylcellulose, methyl cellulose, starch and hydrolyzed starch. The dispersion preferably contains a carbohydrate such as lactose, glucose or maltose. A mineral mixture of calcium carbonate, steamed bone meal, dicalcium phosphate, iodized sodium chloride, magnesium, ferrous, copper, manganese and cobalt sulphates and a protein concentrate of soybean, fish, blood and sunflower seed meals are referred to.ALSO:A method of producing a dry, free-flowing mineral stable Vitamin A and/or D preparation comprises adding to a Vitamin A and/or D phase at least 2 gm. of 4-methyl-2,6-ditertiary-butyl phenol per 100 Standard Units (i.e. 108 International Units) of Vitamin A and/or D, dispersing this mixture in a liquid or molten state in an aqueous liquid containing a jellifiable film-forming colloid and working up this aqueous emulsion to obtain small dry particles. These particles may be produced by dispersing the aqueous emulsion in an oil such as castor or paraffin oil while warm and cooling to produce discrete particles after which the oil is removed by a suitable solvent, e.g. hexane, acetone, ethanol, isopropanol, methylethyl ketone or n-propanol. Alternatively the particles may be produced by spraying the emulsion into a hot air chamber. The film-forming colloids used may be proteins, e.g. gelatine, blood albumen, or lactalbumin, carboxymethylcellulose, methylcellulose or starch. Preferably the aqueous emulsion contains also one or more carbohydrates, e.g. lactose, glucose or maltose. A "mineral stable preparation" is defined as being one which, having been mixed with mineral mixtures or protein concentrates in dilutions of 1 to 1000 or more, and being kept at room temperature in an atmosphere of at least 55 per cent relative humidity will have a vitamin content of at least 70 per cent of the initial vitamin content after a six months' storage period. The dry preparations may be made up into pills or tablets or mixed with food preparations.