GB789424A - Improvements in or relating to process for producing glutamine - Google Patents

Improvements in or relating to process for producing glutamine

Info

Publication number
GB789424A
GB789424A GB8641/56A GB864156A GB789424A GB 789424 A GB789424 A GB 789424A GB 8641/56 A GB8641/56 A GB 8641/56A GB 864156 A GB864156 A GB 864156A GB 789424 A GB789424 A GB 789424A
Authority
GB
United Kingdom
Prior art keywords
glutamine
water
catalyst
aqueous
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8641/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Minerals and Chemical Corp
Original Assignee
International Minerals and Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Minerals and Chemical Corp filed Critical International Minerals and Chemical Corp
Publication of GB789424A publication Critical patent/GB789424A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Glutamine is obtained by heating a solution of the corresponding optical form of g -glutamyl hydrazide in a solvent containing at least 65 per cent by volume of water in the presence of Raney nickel at a pH greater than 9. The process may be carried out between 50 DEG C. and reflux temperature for 1-3 hours, especially at 65-75 DEG C. Preferably 1-4 parts of catalyst are used per part of glutamyl hydrazide. After the reaction the catalyst is filtered off, any nickel in solution is precipitated with dimethylglyoxime or hydrogen sulphide and the glutamine crystallized out. Examples are given of the production of L-glutamine using as solvents water, aqueous ammonia, methanol, ethanol, isopropanol and dioxane. Other specified solvents are water and butanols, pentanol, tetrahydrofurfuryl alcohol and dimethylformamide. The starting material is made by esterifying glutamic acid at low temperatures (with a sulphuric acid catalyst) by means of an alcohol or phenol to give e.g. the methyl, ethyl, propyl or butyl ester and treating this with hydrazine in aqueous or aqueous-alcoholic solution. Examples are given of these steps.
GB8641/56A 1955-05-19 1956-03-20 Improvements in or relating to process for producing glutamine Expired GB789424A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US789424XA 1955-05-19 1955-05-19

Publications (1)

Publication Number Publication Date
GB789424A true GB789424A (en) 1958-01-22

Family

ID=22147149

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8641/56A Expired GB789424A (en) 1955-05-19 1956-03-20 Improvements in or relating to process for producing glutamine

Country Status (1)

Country Link
GB (1) GB789424A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2144742A (en) * 1983-08-10 1985-03-13 Nuclear Technology Corp Hydrazides of amino-polyacetic acids as chelants

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2144742A (en) * 1983-08-10 1985-03-13 Nuclear Technology Corp Hydrazides of amino-polyacetic acids as chelants
US4609757A (en) * 1983-08-10 1986-09-02 Nuclear Technology Corporation Hydrazides of amino-polyacetic acids as chelants

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