GB759577A - Oral therapeutic preparations containing coconut oil - Google Patents

Oral therapeutic preparations containing coconut oil

Info

Publication number
GB759577A
GB759577A GB24995/54A GB2499554A GB759577A GB 759577 A GB759577 A GB 759577A GB 24995/54 A GB24995/54 A GB 24995/54A GB 2499554 A GB2499554 A GB 2499554A GB 759577 A GB759577 A GB 759577A
Authority
GB
United Kingdom
Prior art keywords
penicillin
oil
sulphate
asprin
sulphadiazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24995/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Laboratories Inc
Original Assignee
Bristol Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Laboratories Inc filed Critical Bristol Laboratories Inc
Publication of GB759577A publication Critical patent/GB759577A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Abstract

A stable suspension for oral therapeutic use comprises a therapeutic agent and coconut oil which has been chemically modified by ester exchange, inter-esterification and/or acidolysis to reduce the setting point below 60 DEG F. (15,5 DEG C.). Up to 20 per cent of a mineral oil, edible oil or injectable oil such as butyl stearate or isopropyl myristate may be present. Other optional additions are (a) surface active agents such as lecithin and polyoxyalkylenesorbitols, (b) fillers such as aluminium hydroxide, talc, magnesium trisilicate, kaolin and calcium carbonate, (c) demulcents such as potassium alginate (d) colours, flavours, sweetening agents such as sugar and saccharin and preservatives. The drugs are preferably milled or micronized. Among those specified are (a) antibiotics such as tetracycline, oxytetracycline, chlortetracycline, streptomycin; penicillin, which may be coated with gums, methyl cellulose, polyvinyl pyrrolidone or sodium carboxymethyl cellulose; chloramphenical, polymycin, neomycin and hacitracin; (b) vitamins, (c) sulphonamides such as sulphapyridine, sulphathiazole, sulphadiazine and sulphamethazine; (d) antihistaminics such as N, N-dimethyl-N-1 benzyl-N1-phenyl ethylene diamine, (e) stimulants such as caffeine and amphetamine, (f) sympathomimetric and adrenergic drugs, e.g. edhedrine and 2-aminohexane, (g) analgesics such as asprin, salicylamide and phenacetin, (h) laxatives, e.g. phenolphthalein, (i) sedatives such as amytal (j) anticonvulsants such as phenobarbitone, (k) antimalarials such as atabrine, (l) anticoagulants such as heparin, (m) hormones such as cortisone, (n) minerals such as salts of iron, copper, zinc and calcium, (o) alkaloids, (p) contrast media such as barium sulphate. The following synergistic combinations are specified (1) penicillin and antihistamine, (2) aspirin and codeine, (3) tetracycline and chlortetracycline, (4) sulphadiazine and sulphamerazine, (5) streptomycin sulphate, levo-primaric-6, 8a-cisendo-succinate and dihydrostreptomycin sulphate, (6) asprin, phenacetin and caffeine, (7) sodium penicillin and procaine penicillin. Specification 665,367 is referred to.
GB24995/54A 1953-12-17 1954-08-27 Oral therapeutic preparations containing coconut oil Expired GB759577A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US759577XA 1953-12-17 1953-12-17

Publications (1)

Publication Number Publication Date
GB759577A true GB759577A (en) 1956-10-17

Family

ID=22129005

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24995/54A Expired GB759577A (en) 1953-12-17 1954-08-27 Oral therapeutic preparations containing coconut oil

Country Status (1)

Country Link
GB (1) GB759577A (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3041239A (en) * 1959-05-28 1962-06-26 Johnson & Johnson Stable aqueous salicylamide composition and method of preparing same
US3065138A (en) * 1959-10-09 1962-11-20 Warren Teed Products Company Therapeutic preparations of elemental iron
US3073742A (en) * 1957-04-09 1963-01-15 Byk Gulden Lomberg Chem Fab Stable, bacteriostatic composition
US3075879A (en) * 1960-03-21 1963-01-29 Strully Leonard Vincent Composition of matter and process for the control of drug resistant microorganisms
US3089818A (en) * 1960-06-02 1963-05-14 Baxter Laboratories Inc Water dispersible antibiotics
US3096241A (en) * 1959-07-13 1963-07-02 Wallace & Tiernan Inc Synergistic antihistamine mixture
US3097135A (en) * 1960-02-04 1963-07-09 Abbott Lab Erythromycin suspensions and method of stabilizing the same
US3113071A (en) * 1961-10-13 1963-12-03 Wisconsin Alumni Res Found Rodenticide food bait containing anticoagulant and antibacterial agents
US3121044A (en) * 1960-10-06 1964-02-11 Beecham Res Lab Three-layer compressed penicillin tablet
US3149036A (en) * 1961-10-16 1964-09-15 Merck & Co Inc Adjuvant vaccine with aluminum monostearate, mannide monooleate, vegetable oil, and an aqueous phase immunolgical agent
US3238103A (en) * 1961-04-26 1966-03-01 Clarence A Vogenthaler Therapeutic composition and method of making it
US3549766A (en) * 1965-06-02 1970-12-22 Carter Wallace Reducing hypersensitivity to penicillins with certain phenoxypropanols
WO2010019255A1 (en) * 2008-08-13 2010-02-18 Virun, Inc. Compositions containing aminoalkanes and aminoalkane derivatives
WO2013003947A1 (en) * 2011-07-05 2013-01-10 Reinhold Vieth Iron supplement composition
US9351517B2 (en) 2013-03-15 2016-05-31 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and compositions containing same

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073742A (en) * 1957-04-09 1963-01-15 Byk Gulden Lomberg Chem Fab Stable, bacteriostatic composition
US3041239A (en) * 1959-05-28 1962-06-26 Johnson & Johnson Stable aqueous salicylamide composition and method of preparing same
US3096241A (en) * 1959-07-13 1963-07-02 Wallace & Tiernan Inc Synergistic antihistamine mixture
US3065138A (en) * 1959-10-09 1962-11-20 Warren Teed Products Company Therapeutic preparations of elemental iron
US3097135A (en) * 1960-02-04 1963-07-09 Abbott Lab Erythromycin suspensions and method of stabilizing the same
US3075879A (en) * 1960-03-21 1963-01-29 Strully Leonard Vincent Composition of matter and process for the control of drug resistant microorganisms
US3089818A (en) * 1960-06-02 1963-05-14 Baxter Laboratories Inc Water dispersible antibiotics
US3121044A (en) * 1960-10-06 1964-02-11 Beecham Res Lab Three-layer compressed penicillin tablet
US3238103A (en) * 1961-04-26 1966-03-01 Clarence A Vogenthaler Therapeutic composition and method of making it
US3113071A (en) * 1961-10-13 1963-12-03 Wisconsin Alumni Res Found Rodenticide food bait containing anticoagulant and antibacterial agents
US3149036A (en) * 1961-10-16 1964-09-15 Merck & Co Inc Adjuvant vaccine with aluminum monostearate, mannide monooleate, vegetable oil, and an aqueous phase immunolgical agent
US3549766A (en) * 1965-06-02 1970-12-22 Carter Wallace Reducing hypersensitivity to penicillins with certain phenoxypropanols
WO2010019255A1 (en) * 2008-08-13 2010-02-18 Virun, Inc. Compositions containing aminoalkanes and aminoalkane derivatives
WO2013003947A1 (en) * 2011-07-05 2013-01-10 Reinhold Vieth Iron supplement composition
US10188677B2 (en) 2011-07-05 2019-01-29 The D Drops Company Inc. Iron supplement composition
US9351517B2 (en) 2013-03-15 2016-05-31 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and compositions containing same

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