GB757165A - Compositions of erythromycin for combating bacterial infections - Google Patents
Compositions of erythromycin for combating bacterial infectionsInfo
- Publication number
- GB757165A GB757165A GB25189/53A GB2518954A GB757165A GB 757165 A GB757165 A GB 757165A GB 25189/53 A GB25189/53 A GB 25189/53A GB 2518954 A GB2518954 A GB 2518954A GB 757165 A GB757165 A GB 757165A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- stearate
- erythromycin
- salt
- stearic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Erythromycin stearate is prepared by reacting erythromycin base dissolved in methanol with stearic acid at about 50 DEG C. After filtering the solution the stearate is precipitated by excess of water, filtered off, washed with water and dried in vacuo. The salt may be used in therapeutic compositions (see Group VI).ALSO:A substantially dry therapeutic composition comprises erythromycin stearate and a physiologically acceptable buffer which is a base or a salt of a weak acid and a strong base. Suitable buffers include aluminium hydroxide, calcium hydroxide, sodium citrate, sodium acetate, magnesium trisilicate, sodium phosphate, calcium carbonate, sodium bicarbonate and sodium carbonate. Additional ingredients of the composition may be sulphonamides such as sulphadiazine, sulphamerazine and sulphamethazine either as the free acid or sodium salt and other antibiotics such as penicillin, fumagillin and the tetracyclines. The composition may be formed as a tablet together with the usual tabletting materials such as corn starch, magnesium stearate, stearic acid, sulphated fatty alcohols, sodium carboxymethyl cellulose and polyvinyl pyrrolidone, or as powder which may be placed in a capsule. In an example tablets are prepared from a mixture of erythromycin stearate, sodium citrate, corn starch, magnesium stearate and stearic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US757165XA | 1953-10-30 | 1953-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB757165A true GB757165A (en) | 1956-09-12 |
Family
ID=22127554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB25189/53A Expired GB757165A (en) | 1953-10-30 | 1954-08-30 | Compositions of erythromycin for combating bacterial infections |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB757165A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0349514A1 (en) * | 1988-07-01 | 1990-01-03 | "PHARLYSE", Société Anonyme | Prolonged-release pharmaceutical composition containing erythromycine, its preparation and its use |
| WO1995022319A1 (en) * | 1994-02-16 | 1995-08-24 | Abbott Laboratories | Process for preparing fine particle pharmaceutical formulations |
-
1954
- 1954-08-30 GB GB25189/53A patent/GB757165A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0349514A1 (en) * | 1988-07-01 | 1990-01-03 | "PHARLYSE", Société Anonyme | Prolonged-release pharmaceutical composition containing erythromycine, its preparation and its use |
| BE1002079A4 (en) * | 1988-07-01 | 1990-06-19 | S M B Lab | SUSTAINED RELEASE ERYTHROMYCIN PHARMACEUTICAL COMPOSITION, ITS PREPARATION AND ITS USE. |
| WO1995022319A1 (en) * | 1994-02-16 | 1995-08-24 | Abbott Laboratories | Process for preparing fine particle pharmaceutical formulations |
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