GB693386A - Improvements in or relating to the manufacture of p-amino-salicyclic acid - Google Patents
Improvements in or relating to the manufacture of p-amino-salicyclic acidInfo
- Publication number
- GB693386A GB693386A GB2896550A GB2896550A GB693386A GB 693386 A GB693386 A GB 693386A GB 2896550 A GB2896550 A GB 2896550A GB 2896550 A GB2896550 A GB 2896550A GB 693386 A GB693386 A GB 693386A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acidifying
- manufacture
- precipitate
- separating
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
In a batch process for the manufacture of p-aminosalicylic acid, m-aminophenol is heated in water with potassium carbonate, bicarbonate or hydroxide, in an atmosphere of carbon dioxide, at not below 75 DEG C., cooling, separating and acidifying the liquid with sulphuric acid to pH approximately 6, separating the solid potassium sulphate, warming the liquid to 35-40 DEG C., acidifying with sulphuric acid to 5.1 or 5.0 pH, to precipitate the p-aminosalicylic acid, washing the precipitate, concentrating the filtrate and washings and returning, with added potassium bicarbonate to the residue of unreacted starting-materials for a further batch reaction. Superatmospheric pressure may be employed. Reducing agents such as sodium hydrosulphite or hyposulphite may be added in acidifying, with or without animal charcoal or other decolorizing agent. In an example, 30 repetitions of the process gave a 95 per cent yield of the product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2896550A GB693386A (en) | 1950-11-27 | 1950-11-27 | Improvements in or relating to the manufacture of p-amino-salicyclic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2896550A GB693386A (en) | 1950-11-27 | 1950-11-27 | Improvements in or relating to the manufacture of p-amino-salicyclic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB693386A true GB693386A (en) | 1953-07-01 |
Family
ID=10284069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2896550A Expired GB693386A (en) | 1950-11-27 | 1950-11-27 | Improvements in or relating to the manufacture of p-amino-salicyclic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB693386A (en) |
-
1950
- 1950-11-27 GB GB2896550A patent/GB693386A/en not_active Expired
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