GB787282A - Process for the manufacture of isonicotinyl hydrazide - Google Patents
Process for the manufacture of isonicotinyl hydrazideInfo
- Publication number
- GB787282A GB787282A GB1875155A GB1875155A GB787282A GB 787282 A GB787282 A GB 787282A GB 1875155 A GB1875155 A GB 1875155A GB 1875155 A GB1875155 A GB 1875155A GB 787282 A GB787282 A GB 787282A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyanopyridine
- catalyst
- water
- manufacture
- hydrazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Catalysts (AREA)
- Pyridine Compounds (AREA)
Abstract
Isonicotinyl hydrazide is made by reacting hydrazine with 4-cyanopyridine at an elevated temperature, preferably between 80 DEG C. and the boiling-point of the solution, in the presence of water, with or without a water-miscible organic solvent and optionally in the presence of an alkaline compound, such as an oxide, hydroxide or carbonate of an alkali or alkaline earth metal or magnesium, as a catalyst. The concentration of the 4-cyanopyridine in the reaction mixture is preferably kept below 10 per cent. Examples describe the reaction of 4-cyanopyridine with hydrazine in the absence of a catalyst and in the presence of magnesium oxide, and sodium hydroxide as catalysts. Specifications 776,313 and 785,346 are referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1875155A GB787282A (en) | 1955-06-29 | 1955-06-29 | Process for the manufacture of isonicotinyl hydrazide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1875155A GB787282A (en) | 1955-06-29 | 1955-06-29 | Process for the manufacture of isonicotinyl hydrazide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB787282A true GB787282A (en) | 1957-12-04 |
Family
ID=10117775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1875155A Expired GB787282A (en) | 1955-06-29 | 1955-06-29 | Process for the manufacture of isonicotinyl hydrazide |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB787282A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021069975A1 (en) * | 2019-10-10 | 2021-04-15 | Nelson Mandela University | A continuous flow synthesis method for the manufacture of isoniazid |
-
1955
- 1955-06-29 GB GB1875155A patent/GB787282A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021069975A1 (en) * | 2019-10-10 | 2021-04-15 | Nelson Mandela University | A continuous flow synthesis method for the manufacture of isoniazid |
| CN114981244A (en) * | 2019-10-10 | 2022-08-30 | 纳尔逊·曼德拉大学 | Continuous flow synthesis method for preparing isoniazid |
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