GB668567A - Improvements in or relating to a method of preparing a stable theophylline composition and the product resulting therefrom - Google Patents
Improvements in or relating to a method of preparing a stable theophylline composition and the product resulting therefromInfo
- Publication number
- GB668567A GB668567A GB17323/49A GB1732349A GB668567A GB 668567 A GB668567 A GB 668567A GB 17323/49 A GB17323/49 A GB 17323/49A GB 1732349 A GB1732349 A GB 1732349A GB 668567 A GB668567 A GB 668567A
- Authority
- GB
- United Kingdom
- Prior art keywords
- theophylline
- relating
- preparing
- stable
- resulting therefrom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Theophylline is stabilized by admixture with o-, m- or p-aminobenzoic acid in the presence of an alkali metal hydroxide, such as sodium and potassium hydroxides. Preferably, equimolar proportions of the aminobenzoic acid and theophylline are mixed with water and one to two molecules of alkali metal hydroxide added until complete solution occurs at room temperature. A product containing 45 to 55 per cent free theophylline is prepared and has a solubility at 28 DEG C. of 15 to 50 grms. per 100 mils of solution and a pH of 9.2 to 9.5. Specification 624,696 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US668567XA | 1949-01-11 | 1949-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB668567A true GB668567A (en) | 1952-03-19 |
Family
ID=22072157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17323/49A Expired GB668567A (en) | 1949-01-11 | 1949-06-30 | Improvements in or relating to a method of preparing a stable theophylline composition and the product resulting therefrom |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB668567A (en) |
-
1949
- 1949-06-30 GB GB17323/49A patent/GB668567A/en not_active Expired
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