GB653679A - Improvements in or relating to the production of compounds having vitamin a activity - Google Patents

Improvements in or relating to the production of compounds having vitamin a activity

Info

Publication number
GB653679A
GB653679A GB1706/48A GB170648A GB653679A GB 653679 A GB653679 A GB 653679A GB 1706/48 A GB1706/48 A GB 1706/48A GB 170648 A GB170648 A GB 170648A GB 653679 A GB653679 A GB 653679A
Authority
GB
United Kingdom
Prior art keywords
benzene
acid
hydrogenation
dehydration
effected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1706/48A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of GB653679A publication Critical patent/GB653679A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds having vitamin A activity are obtained by subjecting a compound of the formula <FORM:0653679/IV (b)/1> to hydrogenation to produce a compound of the formula <FORM:0653679/IV (b)/2> which is subjected to alkali isomerization and if desired dehydrated. Preferably the hydrogenation is effected catalytically using a poisoned Raney nickel catalyst and the alkali isomerization is effected by treating the hydrogenated compound with a strongly alkaline substance such as sodium hydroxide, a sodium alkoxide in alcohol, or a quaternary ammonium hydroxide. Dehydration may be effected using benzoyl chloride in pyridine, acetyl chloride in dimethyl aniline, glacial acetic acid, glacial acetic acid and potassium acetate, toluenesulphonic acid in benzene, oxalic acid in benzene, glacial acetic acid in benzene, catalytic quantities of iodine in benzene and phenyl isocyanate in benzene. Detailed examples are given. The Specification as open to inspection under Sect. 91 comprises the steps of hydrogenation, dehydration, and acid or alkali isomerization in any desired order but excludes these steps in the order of hydrogenation, acid isomerization and dehydration. This subject-matter does not appear in the Specification as accepted.
GB1706/48A 1947-10-03 1948-01-20 Improvements in or relating to the production of compounds having vitamin a activity Expired GB653679A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US653679XA 1947-10-03 1947-10-03

Publications (1)

Publication Number Publication Date
GB653679A true GB653679A (en) 1951-05-23

Family

ID=22062222

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1706/48A Expired GB653679A (en) 1947-10-03 1948-01-20 Improvements in or relating to the production of compounds having vitamin a activity

Country Status (1)

Country Link
GB (1) GB653679A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1027661B (en) * 1954-04-22 1958-04-10 Eastman Kodak Co Process for the production of vitamin A-aldehyde from 3, 7-dioxyvitamin A-aldehyde acetals

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1027661B (en) * 1954-04-22 1958-04-10 Eastman Kodak Co Process for the production of vitamin A-aldehyde from 3, 7-dioxyvitamin A-aldehyde acetals

Similar Documents

Publication Publication Date Title
GB653679A (en) Improvements in or relating to the production of compounds having vitamin a activity
GB864926A (en) Process for preparing novel compounds of the lactone type
GB733650A (en) Isophorone and its homologues
GB731917A (en) Manufacture of 2-ethyl-hexanal-(1) and 2-ethyl-hexanol-(1)
GB759950A (en) Production of silver of bactericidal and catalytic activity
SU140794A1 (en) The method of obtaining 6-methyl-heptadiene-3,5-one-2
GB999255A (en) Novel unsaturated alcohols and a process for the preparation thereof
GB778871A (en) Pyridinediol oxides and acetates thereof and their preparation
GB1106088A (en) Process for the preparation of phloroglucinol
NL7501303A (en) PROCEDURE FOR PREPARING GLYCOLETHERS.
GB509890A (en) Manufacture of ethers of mono-hydroxy-halogen-1:4-benzoquinones
GB616853A (en) Improvements in or relating to the manufacture of monoethers of butenetriol
GB788302A (en) The manufacture of geranyl-acetone and dihydrogeranyl-acetone and of hexahydro-pseudoionone therefrom
Fuson et al. Formation of a Seven-membered Cyclic Disulfide from 1, 2-Dibromohydrin and a 1, 2-Dithiol
GB460248A (en) Manufacture of 2-aminoquinizarin and the substitution products thereof
GB648904A (en) Process for the manufacture of 2:4:5-triamino-6-hydroxy-pyrimidine
GB537976A (en) A process for the preparation of di-phenyl ethylene derivatives
GB693175A (en) New substituted propanolamines and the production thereof
DE948348C (en) Process for the preparation of a nitro dye
GB285451A (en) Process for the preparation of aromatic oxyaldehydes
GB445405A (en) Process for the manufacture of n-aryl-glucamines
GB776262A (en) Manufacture of cyclohexanone
GB688211A (en) The manufacture of derivatives of amino acids
GB593021A (en) Sulphonyl derivatives of melamine and processes for their production
GB573120A (en) Process for the manufacture of alkylated phenyl-isopropyl-amines