GB651433A - Improvements relating to the synthesis of bis-quaternary salts - Google Patents

Improvements relating to the synthesis of bis-quaternary salts

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Publication number
GB651433A
GB651433A GB1436848A GB1436848A GB651433A GB 651433 A GB651433 A GB 651433A GB 1436848 A GB1436848 A GB 1436848A GB 1436848 A GB1436848 A GB 1436848A GB 651433 A GB651433 A GB 651433A
Authority
GB
United Kingdom
Prior art keywords
formula
carbon atoms
alkyl
bis
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1436848A
Inventor
Frederick Charles Copp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB1436848A priority Critical patent/GB651433A/en
Publication of GB651433A publication Critical patent/GB651433A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bis-quaternary salts of the formula <FORM:0651433/IV (b)/1> where R1, R2 and R3 are the same or different alkyl groups containing not more than five carbon atoms (or R1 and R2 form a ring with the nitrogen atom, e.g. a piperidine or morpholine ring), A and B are alkyl (of not more than seven carbon atoms), aryl or aralkyl radicals, M is a divalent ion such as SO4 or two monovalent ions such as Cl so that the salt is water-soluble, and the rings C and D and any aromatic portions of A and B may bear alkoxy or alkyl substituents, are prepared by treating with an alkyl ester a compound of the formula <FORM:0651433/IV (b)/2> where A, B, R1 and R2 are as above, except that R1 and/or R2 may be hydrogen. The reaction is usually carried out in a mutual neutral solvent such as methyl alcohol, and, if R1 and/or R2 is hydrogen, an acid-binding agent such as sodium carbonate is added. Methyl iodide is the preferred alkylating agent. Examples are given. Basic ethers of the formula II are obtained from ketones of the formula <FORM:0651433/IV (b)/3> as described in Specification 651,445, e.g. by reduction of the dioximes, further examples being included. 4 : 41-Dibenzoyl-diphenylether is prepared by condensing diphenyl ether with benzoyl chloride in the presence of aluminium chloride. The provisional Specification is not limited as regards the number of carbon atoms in A, B, R1, R2 and R3.
GB1436848A 1948-05-27 1948-05-27 Improvements relating to the synthesis of bis-quaternary salts Expired GB651433A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1436848A GB651433A (en) 1948-05-27 1948-05-27 Improvements relating to the synthesis of bis-quaternary salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1436848A GB651433A (en) 1948-05-27 1948-05-27 Improvements relating to the synthesis of bis-quaternary salts

Publications (1)

Publication Number Publication Date
GB651433A true GB651433A (en) 1951-04-04

Family

ID=10039953

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1436848A Expired GB651433A (en) 1948-05-27 1948-05-27 Improvements relating to the synthesis of bis-quaternary salts

Country Status (1)

Country Link
GB (1) GB651433A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182085A (en) * 1961-03-29 1965-05-04 Dow Chemical Co Products prepared from the reaction of halomethylated diphenyl oxide and amines
US3219698A (en) * 1962-01-26 1965-11-23 Borden Co Polyhaloxylenol quaternary ammonium salts

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182085A (en) * 1961-03-29 1965-05-04 Dow Chemical Co Products prepared from the reaction of halomethylated diphenyl oxide and amines
US3219698A (en) * 1962-01-26 1965-11-23 Borden Co Polyhaloxylenol quaternary ammonium salts

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