ES342460A1 - Process for the production of piperazine derivatives - Google Patents

Process for the production of piperazine derivatives

Info

Publication number
ES342460A1
ES342460A1 ES342460A ES342460A ES342460A1 ES 342460 A1 ES342460 A1 ES 342460A1 ES 342460 A ES342460 A ES 342460A ES 342460 A ES342460 A ES 342460A ES 342460 A1 ES342460 A1 ES 342460A1
Authority
ES
Spain
Prior art keywords
general formula
carbon atoms
benzoic acid
acid
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES342460A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Farbwerke Mainkur AG filed Critical Cassella Farbwerke Mainkur AG
Publication of ES342460A1 publication Critical patent/ES342460A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel piperazine derivatives of the general formula and salts thereof, wherein R stands for an alkyl radical having 1 or 2 carbon atoms, R 1 means hydrogen or an alkoxy radical having 1 or 2 carbon atoms, and A 1 and A 2 represent straight or branched chain alkylene radicals containing 1-4 carbon atoms, and A 2 may be substituted by a methoxy radical are obtained (a) by reacting a trialkoxy benzoic acid having the general formula or a functional derivative thereof, with an alcohol having the general formula if desired in the presence of an acid-binding agent, or (b) by condensing a trialkoxy benzoic acid haloalkyl ester having the formula wherein Hal represents a halogen atom, with a piperazine derivative having the general formula if desired in the presence of an acid-binding agent or (c) by reacting an alkali metal salt of a trialkoxy benzoic acid having the general formula with a piperazine derivative of the general formula Pharmaceutical compositions having coronary dilatory activity and containing the above compounds are administered orally or parenterally.
ES342460A 1966-07-02 1967-06-30 Process for the production of piperazine derivatives Expired ES342460A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEC0039517 1966-07-02

Publications (1)

Publication Number Publication Date
ES342460A1 true ES342460A1 (en) 1968-09-16

Family

ID=7023770

Family Applications (1)

Application Number Title Priority Date Filing Date
ES342460A Expired ES342460A1 (en) 1966-07-02 1967-06-30 Process for the production of piperazine derivatives

Country Status (10)

Country Link
AT (2) AT271481B (en)
BE (1) BE700811A (en)
CH (1) CH489509A (en)
DE (1) DE1670360A1 (en)
DK (1) DK120133B (en)
ES (1) ES342460A1 (en)
FR (2) FR1530040A (en)
GB (1) GB1127993A (en)
IL (1) IL28197A (en)
NL (1) NL6708818A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2280634A2 (en) * 1974-07-31 1976-02-27 Synthelabo 4-Phenyl-piperazino-alkyl anthranilate deriv prepn. - from 2-nitro-benzoic acid via acid halide or salts, condensation with phenyl-piperazino-alkyl radical and reduction
JPS53112886A (en) * 1977-03-12 1978-10-02 Nippon Shinyaku Co Ltd Production of n-substituted trialkoxybenzylpiperazine derivative
JPS53112887A (en) * 1977-03-12 1978-10-02 Nippon Shinyaku Co Ltd Production of n-substituted trialkoxybenzylpiperazine derivative
HU173380B (en) * 1977-02-25 1979-04-28 Richter Gedeon Vegyeszet Process for producing new pyridyl-piperazine derivatives and acid additional salts thereof
CA3068254A1 (en) * 2017-06-20 2018-12-27 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism

Also Published As

Publication number Publication date
NL6708818A (en) 1968-01-03
DK120133B (en) 1971-04-13
AT272354B (en) 1969-07-10
BE700811A (en) 1968-01-02
FR7173M (en) 1969-08-11
DE1670360A1 (en) 1970-10-29
CH489509A (en) 1970-04-30
FR1530040A (en) 1968-06-21
GB1127993A (en) 1968-09-25
AT271481B (en) 1969-06-10
IL28197A (en) 1971-05-26

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