GB2546683B - Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF - Google Patents

Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF

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Publication number
GB2546683B
GB2546683B GB1706843.8A GB201706843A GB2546683B GB 2546683 B GB2546683 B GB 2546683B GB 201706843 A GB201706843 A GB 201706843A GB 2546683 B GB2546683 B GB 2546683B
Authority
GB
United Kingdom
Prior art keywords
fgf
methods
progenitor cells
cells differentiated
pancreatic progenitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1706843.8A
Other versions
GB201706843D0 (en
GB2546683A (en
Inventor
Lee Jau-Nan
Tung-Yin Lee Tony
Lee Yuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Accelerated Biosciences Corp
Original Assignee
Accelerated Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accelerated Biosciences Corp filed Critical Accelerated Biosciences Corp
Priority to GB1706843.8A priority Critical patent/GB2546683B/en
Priority claimed from GB1511132.1A external-priority patent/GB2523696B/en
Publication of GB201706843D0 publication Critical patent/GB201706843D0/en
Publication of GB2546683A publication Critical patent/GB2546683A/en
Application granted granted Critical
Publication of GB2546683B publication Critical patent/GB2546683B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65—MicroRNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
GB1706843.8A 2013-11-26 2013-11-26 Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF Active GB2546683B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1706843.8A GB2546683B (en) 2013-11-26 2013-11-26 Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1511132.1A GB2523696B (en) 2012-11-30 2013-11-26 Methods of differentiating stem cells to pancreatic progenitor cells by modulating miR-124
GB1706843.8A GB2546683B (en) 2013-11-26 2013-11-26 Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF

Publications (3)

Publication Number Publication Date
GB201706843D0 GB201706843D0 (en) 2017-06-14
GB2546683A GB2546683A (en) 2017-07-26
GB2546683B true GB2546683B (en) 2017-12-13

Family

ID=59010899

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1706843.8A Active GB2546683B (en) 2013-11-26 2013-11-26 Methods of producing betatrophin from pancreatic progenitor cells differentiated using FGF

Country Status (1)

Country Link
GB (1) GB2546683B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091766A2 (en) * 2005-02-24 2006-08-31 Jau-Nan Lee Human trophoblast stem cells and use thereof
WO2009132083A2 (en) * 2008-04-22 2009-10-29 President And Fellows Of Harvard College Compositions and methods for promoting the generation of pdx1+ pancreatic cells
EP2233566A1 (en) * 2009-03-17 2010-09-29 Vrije Universiteit Brussel Generation of pancreatic progenitor cells
WO2012068170A2 (en) * 2010-11-15 2012-05-24 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
US20120264209A1 (en) * 2006-05-02 2012-10-18 Jon Odorico Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091766A2 (en) * 2005-02-24 2006-08-31 Jau-Nan Lee Human trophoblast stem cells and use thereof
US20120264209A1 (en) * 2006-05-02 2012-10-18 Jon Odorico Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
WO2009132083A2 (en) * 2008-04-22 2009-10-29 President And Fellows Of Harvard College Compositions and methods for promoting the generation of pdx1+ pancreatic cells
EP2233566A1 (en) * 2009-03-17 2010-09-29 Vrije Universiteit Brussel Generation of pancreatic progenitor cells
WO2012068170A2 (en) * 2010-11-15 2012-05-24 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Biological Chemistry, vol. 389, 2008, Lovis et al, 'Regulation of the expression of components of the exocytotic machinery...' pp. 305-312 *
Cell Research, vol. 17, 2007, Jiang et al, 'In vitro derivation of functional insulin-producing cells...' pp. 333-344 *
Journal of Biological Chemistry, vol. 282 issue 27, 2007, Baroukh et al, 'MicroRNA-124a regulates Foxa2 expression...' pp. 19575-19588 *
Mechanisms of Development, vol. 128, 2011, Xu et al, 'Activin, BMP and FGF pathways cooperate...' pp. 412-427 *
PLoS ONE, volume 7 issue 12, 2012, Lee et al, 'Ectopic pregnancy-derived human trophoblastic stem cells...' article e52491. Available online at https://doi.org/10.1371/journal.pone.0052491 [Accessed 18 May 2017] *

Also Published As

Publication number Publication date
GB201706843D0 (en) 2017-06-14
GB2546683A (en) 2017-07-26

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Effective date: 20170727