GB2455229B - Cryostat and microtome - Google Patents

Cryostat and microtome

Info

Publication number
GB2455229B
GB2455229B GB0904220A GB0904220A GB2455229B GB 2455229 B GB2455229 B GB 2455229B GB 0904220 A GB0904220 A GB 0904220A GB 0904220 A GB0904220 A GB 0904220A GB 2455229 B GB2455229 B GB 2455229B
Authority
GB
United Kingdom
Prior art keywords
cryostat
microtome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB0904220A
Other versions
GB0904220D0 (en
GB2455229A (en
Inventor
David Michael Vicar
Graham Robert Dawson
Mark Stuart Barratt
John Barrand Cox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandon Diagnostics Ltd
Original Assignee
Thermo Shandon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Shandon Ltd filed Critical Thermo Shandon Ltd
Priority to GB0904220A priority Critical patent/GB2455229B/en
Publication of GB0904220D0 publication Critical patent/GB0904220D0/en
Publication of GB2455229A publication Critical patent/GB2455229A/en
Application granted granted Critical
Publication of GB2455229B publication Critical patent/GB2455229B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B9/00—Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
GB0904220A 2004-09-16 2005-09-16 Cryostat and microtome Active GB2455229B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0904220A GB2455229B (en) 2004-09-16 2005-09-16 Cryostat and microtome

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0420657A GB0420657D0 (en) 2004-09-16 2004-09-16 Cryostat and microtome
GB0518961A GB2419660B (en) 2004-09-16 2005-09-16 Cryostat and microtome
GB0904220A GB2455229B (en) 2004-09-16 2005-09-16 Cryostat and microtome

Publications (3)

Publication Number Publication Date
GB0904220D0 GB0904220D0 (en) 2009-04-22
GB2455229A GB2455229A (en) 2009-06-03
GB2455229B true GB2455229B (en) 2009-10-28

Family

ID=33306717

Family Applications (3)

Application Number Title Priority Date Filing Date
GB0420657A Ceased GB0420657D0 (en) 2004-09-16 2004-09-16 Cryostat and microtome
GB0904220A Active GB2455229B (en) 2004-09-16 2005-09-16 Cryostat and microtome
GB0518961A Active GB2419660B (en) 2004-09-16 2005-09-16 Cryostat and microtome

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB0420657A Ceased GB0420657D0 (en) 2004-09-16 2004-09-16 Cryostat and microtome

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB0518961A Active GB2419660B (en) 2004-09-16 2005-09-16 Cryostat and microtome

Country Status (6)

Country Link
US (1) US20080041069A1 (en)
EP (1) EP1800104B1 (en)
JP (1) JP5100384B2 (en)
CN (2) CN101907528B (en)
GB (3) GB0420657D0 (en)
WO (1) WO2006030231A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031136B3 (en) * 2006-07-03 2007-07-26 Leica Microsystems Nussloch Gmbh Crank drive for shaft of microtome, has two shafts with respective transmission units, and third transmission unit is selectively brought in contact with former two transmission units
DE102009061068B4 (en) * 2009-04-17 2015-05-07 Leica Biosystems Nussloch Gmbh Method for producing microscopic thin sections of tissue samples
WO2014014925A2 (en) * 2012-07-17 2014-01-23 Illinois Tool Works Inc. Sample encapsulation system and method
DE102012219684B4 (en) * 2012-10-26 2017-05-11 Leica Biosystems Nussloch Gmbh Portable device for transporting a histological sample
CN103750922B (en) * 2013-12-31 2016-07-13 金仕生物科技（常熟）有限公司 The method preparing Cardiac valve prosthesis leaflet
KR102289821B1 (en) * 2014-10-23 2021-08-13 삼성전자주식회사 Transporting Apparatus and Method for Transporting Using the Same
JP6841609B2 (en) 2015-07-10 2021-03-10 ３スキャン インコーポレイテッド Spatial multiplexing of histological staining
USD803414S1 (en) * 2016-06-19 2017-11-21 Mary Tate Cryostat chuck with identification platform
USD803415S1 (en) * 2016-07-17 2017-11-21 Mary Tate Cryostat chuck with identification platform
CN107817146B (en) * 2017-11-06 2023-08-29 华侨大学 Dual-compression soil sample preparation device and sample preparation method
CN112649265A (en) * 2021-01-11 2021-04-13 燕山大学 Auxiliary device for frozen paraffin dual-purpose slicer and using method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1234045B (en) * 1964-11-24 1967-02-09 Wkf Ges Fuer Elektrophys Appba Cooling process for the production of tissue sections
US5960640A (en) * 1996-09-30 1999-10-05 Microm Laborgerate Gmbh Cryostatic microtome

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533342A (en) * 1895-01-29 Socket-wrench
US3218896A (en) * 1963-04-08 1965-11-23 Ames Lab Tek Inc Specimen freezing device for use with a microtome
US3209821A (en) * 1963-09-23 1965-10-05 Internat Equipment Co Cryostat quick freeze stages and attachments therefor
US3296821A (en) * 1965-05-05 1967-01-10 Malinin Theodore Microtome including freezing attachments
GB1130222A (en) * 1965-11-03 1968-10-09 Rue Frigistor Ltd De Microtome apparatus
AT260573B (en) * 1966-09-08 1968-03-11 Zentrum Fuer Elektronenmikrosk Equipment for the production of cooling cuts for microscopy
SE371501B (en) * 1973-07-16 1974-11-18 Lkb Produkter Ab
GB1518792A (en) * 1975-11-04 1978-07-26 South London Elect Equip Cryostats
JPS61122542A (en) * 1984-11-20 1986-06-10 Chiyoda Seisakusho:Kk Quick freezing device for living body sample
US4615183A (en) * 1985-06-24 1986-10-07 The United States Of America As Represented By The Department Of Health And Human Services Cold plate for laboratory use
US4807442A (en) * 1986-12-03 1989-02-28 Board Of Regents The University Of Texas System Cryo-slamming apparatus and method for ultrarapid cooling of biological samples
JPS63304165A (en) * 1987-06-05 1988-12-12 Chiyoda Seisakusho:Kk Quick freezing method of biosample
US5533342A (en) * 1995-02-08 1996-07-09 Gordon; Abe Semi-automated cryostat
US5628197A (en) * 1995-09-21 1997-05-13 Rada; David C. Tissue freezing apparatus
JPH09196832A (en) * 1996-01-19 1997-07-31 Kobe Steel Ltd Method for cooling analysis sample
US5829256A (en) * 1997-05-12 1998-11-03 Rada; David C. Specimen freezing apparatus
JP3233128B2 (en) * 1997-06-20 2001-11-26 株式会社日立製作所 Biomagnetic field measurement device
AT406309B (en) * 1998-09-01 2000-04-25 Leica Mikrosysteme Ag DEVICE FOR CONTROLLING THE TEMPERATURES IN A REFRIGERATOR CHAMBER FOR A MICROTOME
DE19911163C1 (en) * 1999-03-12 2000-07-20 Leica Microsystems Microtome; has control circuit to control drive motor of drive for operating knife or object motion, according to rotation signals of hand wheel, so that cutting is prevented in case of fault
JP2000283897A (en) * 1999-03-31 2000-10-13 Astec:Kk Control device of sample storage container
US6387653B1 (en) * 1999-04-09 2002-05-14 Culterra, Llc Apparatus and method for automatically producing tissue slides
DE10048724B4 (en) * 2000-09-29 2008-12-04 Leica Biosystems Nussloch Gmbh Device for stretching cryostat sections
US6536219B2 (en) * 2001-05-03 2003-03-25 Steven Peters Apparatus and method for precision cryoembedding of tissue samples
CN2490564Y (en) * 2001-07-25 2002-05-08 中国人民解放军第五三四医院 Quick-frozen cryostat for pathology
ES2241905T3 (en) * 2002-01-22 2005-11-01 Mpb Meltec Patent- Und Beteiligungsgesellschaft Mbh PROCEDURE AND DEVICE FOR THE PREPARATION OF SAMPLES FOR THE ANALYSIS OF BIOLOGICAL SAMPLES.
DE10242712B4 (en) * 2002-09-13 2004-10-21 Leica Mikrosysteme Gmbh Microtome with a control device
DE10244055B8 (en) * 2002-09-21 2005-10-20 Microm Int Gmbh Cryostat microtome with a tempering device
DE10346996B3 (en) * 2003-10-07 2005-05-25 Leica Mikrosysteme Gmbh Microtome with cooling chamber

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1234045B (en) * 1964-11-24 1967-02-09 Wkf Ges Fuer Elektrophys Appba Cooling process for the production of tissue sections
US5960640A (en) * 1996-09-30 1999-10-05 Microm Laborgerate Gmbh Cryostatic microtome

Also Published As

Publication number Publication date
JP5100384B2 (en) 2012-12-19
EP1800104A1 (en) 2007-06-27
EP1800104B1 (en) 2016-08-17
GB0518961D0 (en) 2005-10-26
WO2006030231A1 (en) 2006-03-23
GB2419660B (en) 2009-10-28
US20080041069A1 (en) 2008-02-21
CN101907528B (en) 2012-01-11
GB2419660A (en) 2006-05-03
CN101044388A (en) 2007-09-26
CN101907528A (en) 2010-12-08
GB0420657D0 (en) 2004-10-20
GB0904220D0 (en) 2009-04-22
JP2008513761A (en) 2008-05-01
GB2455229A (en) 2009-06-03
CN101044388B (en) 2011-02-09

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