GB1130222A - Microtome apparatus - Google Patents

Microtome apparatus

Info

Publication number
GB1130222A
GB1130222A GB4650965A GB4650965A GB1130222A GB 1130222 A GB1130222 A GB 1130222A GB 4650965 A GB4650965 A GB 4650965A GB 4650965 A GB4650965 A GB 4650965A GB 1130222 A GB1130222 A GB 1130222A
Authority
GB
United Kingdom
Prior art keywords
chamber
fluid
cooling unit
thermoelectric cooling
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4650965A
Inventor
Donald Moore Barton
Colin Robinson
John Henry Ashby
Richard Kenneth Haynes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
De la Rue Frigistor Ltd
Original Assignee
De la Rue Frigistor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De la Rue Frigistor Ltd filed Critical De la Rue Frigistor Ltd
Priority to GB4650965A priority Critical patent/GB1130222A/en
Priority to US3456538D priority patent/US3456538A/en
Priority to DER33825U priority patent/DE1962263U/en
Priority to FR82319A priority patent/FR1499587A/en
Publication of GB1130222A publication Critical patent/GB1130222A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/283—With means to control or modify temperature of apparatus or work
    • Y10T83/293—Of tool

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

1,130,222. Microtomes. DE LA RUE FRIGISTOR. Nov. 2, 1966 [Nov. 3, 1965; Aug. 25, 1966], Nos.46509/65 and 38282/66. Heading G2J. Microtome apparatus comprising a knife 10 and a specimen holder stage housed in a chamber 1, is provided with primary cooling means for maintaining the temperature in the chamber 1 below that of the surrounding atmosphere, a first thermoelectric cooling unit 9 for controlling the temperature of the knife, a second thermoelectric cooling unit 12 for controlling the temperature of the specimen holder stage, means to permit operation of the apparatus within the closed chamber, and means to control independently the supply of electric power to each of the units 9, 12. A third thermoelectric cooling unit 15 is coupled with a cold storage compartment 16 within the chamber 1. Each thermoelectric cooling unit 9, 12, 15 is coupled with a heat transfer unit 8, 11, 14 respectively through which circulates a cooling fluid. A cooling fluid circulates in a pipe system 17 and so cools the chamber 1. This fluid may also pass through a heat exchanger 6 to cool the cooling fluid in pipes 22 which communicate with the cooling units 9, 12, 15. A refrigerator 5 cools the primary fluid in the pipes 17. A power supply 19 is connected to each thermoelectric cooling unit.
GB4650965A 1965-11-03 1965-11-03 Microtome apparatus Expired GB1130222A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB4650965A GB1130222A (en) 1965-11-03 1965-11-03 Microtome apparatus
US3456538D US3456538A (en) 1965-11-03 1966-10-31 Microtome apparatus
DER33825U DE1962263U (en) 1965-11-03 1966-11-02 MICROTOME.
FR82319A FR1499587A (en) 1965-11-03 1966-11-03 Microtome for cutting slices of material from a sample suitable for microscopic examination

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4650965A GB1130222A (en) 1965-11-03 1965-11-03 Microtome apparatus

Publications (1)

Publication Number Publication Date
GB1130222A true GB1130222A (en) 1968-10-09

Family

ID=10441537

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4650965A Expired GB1130222A (en) 1965-11-03 1965-11-03 Microtome apparatus

Country Status (4)

Country Link
US (1) US3456538A (en)
DE (1) DE1962263U (en)
FR (1) FR1499587A (en)
GB (1) GB1130222A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803958A (en) * 1969-06-02 1974-04-16 Moran H Fernandez Ultra thin sectioning with ultra sharp diamond edge at ultra low temperature
US4262567A (en) * 1979-10-01 1981-04-21 Bettin Elizabeth M Device for cooling microtome blade
US5533342A (en) * 1995-02-08 1996-07-09 Gordon; Abe Semi-automated cryostat
AT406309B (en) * 1998-09-01 2000-04-25 Leica Mikrosysteme Ag DEVICE FOR CONTROLLING THE TEMPERATURES IN A REFRIGERATOR CHAMBER FOR A MICROTOME
DE10048724B4 (en) * 2000-09-29 2008-12-04 Leica Biosystems Nussloch Gmbh Device for stretching cryostat sections
DE10244055B8 (en) * 2002-09-21 2005-10-20 Microm Int Gmbh Cryostat microtome with a tempering device
EP1508452B1 (en) * 2003-08-19 2008-11-19 Konica Minolta Business Technologies, Inc. Ink jet printer
DE20318093U1 (en) * 2003-11-22 2004-02-12 Leica Microsystems Nussloch Gmbh Cryostat with an integrated staining station
GB0420657D0 (en) * 2004-09-16 2004-10-20 Thermo Shandon Ltd Cryostat and microtome
DE102005037060B4 (en) * 2005-08-05 2013-10-17 Leica Mikrosysteme Gmbh Method for reducing the humidity in the vicinity of the cooling chamber of a device for cutting samples
DE102010010694B4 (en) * 2010-03-08 2011-10-13 Michael Gudo Microtome with sample cooling
DE102010016728B4 (en) * 2010-04-30 2011-11-24 Leica Biosystems Nussloch Gmbh RM CoolClamp with an air duct for dissipating the heat of a cooling element and microtome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB992979A (en) * 1962-06-07 1965-05-26 Frigistor Lab Ltd Microtomes
GB975795A (en) * 1962-10-15 1964-11-18 Reichert Optische Werke Ag Microtome
US3204424A (en) * 1962-10-23 1965-09-07 Ames Atomium Inc Microtome specimen-freezing apparatus
US3296821A (en) * 1965-05-05 1967-01-10 Malinin Theodore Microtome including freezing attachments

Also Published As

Publication number Publication date
US3456538A (en) 1969-07-22
FR1499587A (en) 1967-10-27
DE1962263U (en) 1967-06-15

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