GB2394715A - Rubber composition - Google Patents

Rubber composition Download PDF

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Publication number
GB2394715A
GB2394715A GB0225021A GB0225021A GB2394715A GB 2394715 A GB2394715 A GB 2394715A GB 0225021 A GB0225021 A GB 0225021A GB 0225021 A GB0225021 A GB 0225021A GB 2394715 A GB2394715 A GB 2394715A
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GB
United Kingdom
Prior art keywords
composition according
rubber
composition
polychloroprene
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0225021A
Other versions
GB0225021D0 (en
Inventor
Terence Driver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icon Polymer Group Ltd
Original Assignee
Icon Polymer Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icon Polymer Group Ltd filed Critical Icon Polymer Group Ltd
Priority to GB0225021A priority Critical patent/GB2394715A/en
Publication of GB0225021D0 publication Critical patent/GB0225021D0/en
Publication of GB2394715A publication Critical patent/GB2394715A/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L11/00—Compositions of homopolymers or copolymers of chloroprene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/16—Elastomeric ethene-propene or ethene-propene-diene copolymers, e.g. EPR and EPDM rubbers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/14—Peroxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

A rubber composition containing no carbon black comprises ethylene-propylene-diene monomer (EPDM) rubber and G-type polychloroprene cured in the presence of a peroxide/metal oxide vulcanising system. The composition is suitable for use in a pharmaceutical drug delivery apparatus, such as an inhaler, using a hydrofluoroalkane propellant. The polychloroprene is preferably neoprene. A filler such as a silica, silicate or ceramic may be present. A co-curing agent such as ethylene glycol methacrylate may also be present as may a plasticiser such as ethylene glycol. Also claimed is a pharmaceutical drug delivery apparatus comprising a rubber component formed from such a rubber composition.

Description

Rubber Compositions This invention relates to rubber compositions
particularly for use in the pharmaceutical industry in aerosol dispensers.
Pharmaceutical dispensing equipment, particularly inhalers used for delivering aerosols for inhalation, has traditionally used chlorofluorocarbons (CFCs) as propellants. Recent regulations have led to the adoption of hydrofluoroalkanes (HFAs) as replacement propellants. Delivery devices such as aerosol sprays include rubber seals (for example in the valve). Conventionally these have been manufactured from acrylonitrile butadiene rubbers or ethylene propylene diene monomer (EPDM) rubber reinforced with carbon black white mineral fillers. The change to HFA propellants means that the typical plasticisers used in the above mentioned rubber compositions (typically polypropylene esters such as polypropylene adipate) can no longer be used because they are extractable by the HFA. Without them, however, the compositions become difficult or impossible to process, and no satisfactory replacements have been devised.
There is thus a need for a white, HFA-tolerant rubber composition for use in aerosol dispensers and the like, which can be easily processed and which exhibits the required physical and chemical properties.
It has now been found that a combination of EPDM rubber and G-type polychloroprene can provide rubber compositions having highly desirable characteristics for use in this field. According to the invention therefore, there is provided a rubber composition
containing no carbon black and suitable for use in pharmaceutical drug delivery apparatus using hydrofluoroalkane propellant, comprising ethylene-propylene-diene monomer (EPDM) rubber and G-type polychloroprene cured in the presence of a peroxide/metal oxide vulcanising system.
In general, the composition will be reinforced with a white mineral reinforcing or filling agent, typically comprising a powdered silica, silicate and/or ceramic compound.
Examples of white fillers include silica, aluminium silicate and calcined china clay.
Unlike the case with acrylonitrile butadiene or plain EPDM rubbers, it is not necessary to use polymeric plasticisers, although a non-extractable process aid such as polyethylene glycol, typically in the molecular weight range 3000-6000, can be added to improve processing. We find that the addition of the polychloroprene provides a green strength giving the resultant composition a higher tensile strength than plain EPDM material filled with white mineral filler would have.
The EPDM/polychloroprene combination is cured in the presence of a peroxide, such as 2,5-dimethyl-2,5-ditertiarybutyl peroxide, and metal oxides, in particular a combination of zinc oxide and magnesium oxide. The composition may be cured in the presence of an additional acrylate cocuring agent, for example ethylene glycol acrylate.
A preferred embodiment of the present invention is now described in comparison with prior art compositions in the following Examples.
Comparative Example 1 Parts by weight per Acrvlonitrile/butadiene rubber compositionhundred rubber Acrylonitrile/butadiene polymer100 Zinc oxide5 Stearic Acid Polymeric plasticiser (polypropylene adipate)20 Carbon black100 Antioxidant1 TMTD tetramethyl thiuram disulphide (vulcanization2 accelerator) METS Mercapto benzothiazole disulphide (vulcanization3 accelerator) Sulphur0.5 Comparative Example 2
Parts by weight Per EPDM Rubber Compositionhundred rubber EPDM100
Zinc oxide5 Stearic Acid Carbon black70 Polymeric plasticiser20 ZBUD Zinc dibutyl dithiocarbamate (vulcanization accelerator)2 TMTD Tetramethyl thiuram disulphide (vulcanisation0.8 accelerator) P25 Dipentamethylene thiuram tetrasulphide (vulcanization accelerator) Sulphur0.5 Example
Parts by weight per EPDM Rubber Compositionhundred rubber EPDM (EPT2450 supplied by Bayer)60 Neoprene GW40 Zinc oxide (curative)6 Magnesium oxide (Garalite DO supplied by Omya)1.6 Calcined china clay (Polestar 200 supplied bY RBH) Silica (VN3 supplied by Degussa)20 Aluminium silicate (Silted AS7 supplied by Degussa)10 Polyethylene glycol (MW3000-6000)3 Ethyl ene glycol dim ethacryl ate (ATM3 Drimix supplied by5 Chemox) 2,5dimethyl-2,5-ditertiary butyl peroxide (Varox DBPH-50 supplied by Vanderbilt) The composition is easily processable and can be extruded, calendered and injection moulded.
Test Results Specification limits Found
Micro hardness 70-75 75 Tensile strength MPa. 12 min. 14 Elongation break % 300 340 Volume Swell % 0-3 2 Comp. Set, ART % 15 max 13.5 Comp. Set, 70 C % 25 max 22 In addition, the composition shows good performance in comparison to standard HFA compatible products in the following tests: shot weights, yearly leakage rates, force to fire, return forces, friction and swell in various propellants.

Claims (10)

CLAIMS:
1. A rubber composition containing no carbon black and suitable for use in pharmaceutical drug delivery apparatus using hydrofluoroalkane propellant comprising ethylene-propylene-diene monomer (EPDM) rubber and G-type polychloroprene cured in the presence of a peroxide/metal oxide vulcanising system.
2. A composition according to claim 1, in which the polychloroprene is neoprene.
3. A composition according to claim 1 or claim 2 containing a mineral reinforcing or filling agent.
4. A composition according to claim 3, in which the mineral comprises a silica, silicate andlor ceramic.
5. A composition according to claim 4, in which the mineral comprises silica, aluminium silicate and/or calcined china clay.
6. A composition according to any of claims 1 to 5, cured in the additional presence of an organic co-curing agent
7. A composition, in which the co-curing agent comprises ethylene glycol dimethacrylate
8. A composition according to any of claims 1 to 7 further comprising a plasticiser which is not extractable in hydrofluoroalkane propellant.
9. A composition according to claim 8, in which the plasticiser is a polyethylene glycol.
10. A pharmaceutical drug delivery apparatus comprising a rubber component formed from a rubber composition according to any of claims 1 to 9.
GB0225021A 2002-10-28 2002-10-28 Rubber composition Withdrawn GB2394715A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0225021A GB2394715A (en) 2002-10-28 2002-10-28 Rubber composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0225021A GB2394715A (en) 2002-10-28 2002-10-28 Rubber composition

Publications (2)

Publication Number Publication Date
GB0225021D0 GB0225021D0 (en) 2002-12-04
GB2394715A true GB2394715A (en) 2004-05-05

Family

ID=9946696

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0225021A Withdrawn GB2394715A (en) 2002-10-28 2002-10-28 Rubber composition

Country Status (1)

Country Link
GB (1) GB2394715A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109651718A (en) * 2018-12-25 2019-04-19 佛山科学技术学院 A kind of EPT rubber cable material that calcinated argil is modified

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114292472A (en) * 2022-01-14 2022-04-08 四川佳世特橡胶有限公司 Formula of hot die butt joint high-cohesiveness vulcanized rubber sealing strip

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118998A1 (en) * 1983-02-08 1984-09-19 C.I. Kasei Co., Ltd A compression-resistant water-swelling rubber composition and watertight sealing material comprising the same
JPH02189342A (en) * 1989-01-17 1990-07-25 Hitachi Cable Ltd Thermosetting polymer blend
US5023006A (en) * 1990-11-30 1991-06-11 The United States Of America As Represented By The Secretary Of The Navy Thermal insulation chemical composition and method of manufacture
US5124390A (en) * 1989-08-25 1992-06-23 The Uniroyal Goodrich Tire Company Calcium sulfate as a partial replacement for titanium dioxide in white compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118998A1 (en) * 1983-02-08 1984-09-19 C.I. Kasei Co., Ltd A compression-resistant water-swelling rubber composition and watertight sealing material comprising the same
JPH02189342A (en) * 1989-01-17 1990-07-25 Hitachi Cable Ltd Thermosetting polymer blend
US5124390A (en) * 1989-08-25 1992-06-23 The Uniroyal Goodrich Tire Company Calcium sulfate as a partial replacement for titanium dioxide in white compounds
US5023006A (en) * 1990-11-30 1991-06-11 The United States Of America As Represented By The Secretary Of The Navy Thermal insulation chemical composition and method of manufacture

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109651718A (en) * 2018-12-25 2019-04-19 佛山科学技术学院 A kind of EPT rubber cable material that calcinated argil is modified

Also Published As

Publication number Publication date
GB0225021D0 (en) 2002-12-04

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