GB2244704B - Substituted benzene compounds - Google Patents

Substituted benzene compounds

Info

Publication number
GB2244704B
GB2244704B GB9010129A GB9010129A GB2244704B GB 2244704 B GB2244704 B GB 2244704B GB 9010129 A GB9010129 A GB 9010129A GB 9010129 A GB9010129 A GB 9010129A GB 2244704 B GB2244704 B GB 2244704B
Authority
GB
United Kingdom
Prior art keywords
substituted benzene
benzene compounds
compounds
substituted
benzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9010129A
Other versions
GB2244704A (en
GB9010129D0 (en
Inventor
Sydney Shall
Manoochehr Tavassoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CONSULTANTS SUPPLIERS Ltd
Original Assignee
CONSULTANTS SUPPLIERS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CONSULTANTS SUPPLIERS Ltd filed Critical CONSULTANTS SUPPLIERS Ltd
Priority to GB9010129A priority Critical patent/GB2244704B/en
Publication of GB9010129D0 publication Critical patent/GB9010129D0/en
Publication of GB2244704A publication Critical patent/GB2244704A/en
Priority to GB9423929A priority patent/GB2281860A/en
Priority to US08/372,785 priority patent/US5719151A/en
Application granted granted Critical
Publication of GB2244704B publication Critical patent/GB2244704B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
    • C07C275/68—N-nitroso ureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB9010129A 1990-05-04 1990-05-04 Substituted benzene compounds Expired - Fee Related GB2244704B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB9010129A GB2244704B (en) 1990-05-04 1990-05-04 Substituted benzene compounds
GB9423929A GB2281860A (en) 1990-05-04 1994-11-26 Substituted benzene compounds as transferase inhibitors
US08/372,785 US5719151A (en) 1990-05-04 1995-01-13 Substituted benzene compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9010129A GB2244704B (en) 1990-05-04 1990-05-04 Substituted benzene compounds

Publications (3)

Publication Number Publication Date
GB9010129D0 GB9010129D0 (en) 1990-06-27
GB2244704A GB2244704A (en) 1991-12-11
GB2244704B true GB2244704B (en) 1995-05-17

Family

ID=10675530

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9010129A Expired - Fee Related GB2244704B (en) 1990-05-04 1990-05-04 Substituted benzene compounds
GB9423929A Withdrawn GB2281860A (en) 1990-05-04 1994-11-26 Substituted benzene compounds as transferase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB9423929A Withdrawn GB2281860A (en) 1990-05-04 1994-11-26 Substituted benzene compounds as transferase inhibitors

Country Status (1)

Country Link
GB (2) GB2244704B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005546B2 (en) 1995-04-03 2006-02-28 Renovis, Inc. Acetamidobenzamide compounds for neurodegenerative disorders

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9011833D0 (en) * 1990-05-25 1990-07-18 Collins Mary K L Inhibition of viral infection
AU688749B2 (en) * 1992-11-30 1998-03-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Mammalian muscle NAD:arginine ADP-ribosyltransferase
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
US5643965A (en) * 1995-04-03 1997-07-01 Centaur Pharmaceuticals, Inc. Aminobenzamide compounds for the treatment of neurodegenerative disorders
US5955506A (en) * 1996-04-03 1999-09-21 Centaur Pharmaceuticals, Inc. Benzamides for neurodegenerative disorder treatment
WO1998027975A1 (en) * 1996-12-20 1998-07-02 Geron Corporation Poly(adp-ribose) polymerase inhibitors to treat diseases associated with cellular senescence
RU2167659C1 (en) * 2000-08-02 2001-05-27 Закрытое акционерное общество "Центр современной медицины "Медикор" Method of correction of immune system of living body

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4936220A (en) * 1972-08-05 1974-04-04
JPS504038A (en) * 1972-12-05 1975-01-16
DE2445529A1 (en) * 1974-09-24 1976-04-01 Bayer Ag Herbicidal N-(alkoxycarbonylphenyl) ureas - esp for selective control of weeds in cotton
EP0064878A1 (en) * 1981-05-08 1982-11-17 Otsuka Pharmaceutical Co., Ltd. Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same
JPS6019754A (en) * 1983-07-14 1985-01-31 Kissei Pharmaceut Co Ltd Production of aromatic carboxylic acid amide derivative
JPS60152454A (en) * 1984-01-18 1985-08-10 Terumo Corp Amide derivative and 5-lipoxigenase inhibitor containing said derivative as active component
JPS62223159A (en) * 1986-03-25 1987-10-01 Ono Pharmaceut Co Ltd (n-substituted phenyl)unsaturated acid amide derivative, production thereof and 5-lipoxygenase inhibitor containing same as active ingredient
EP0314105A2 (en) * 1987-10-29 1989-05-03 Takeda Chemical Industries, Ltd. Angiogenesis enhancer

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4936220A (en) * 1972-08-05 1974-04-04
JPS504038A (en) * 1972-12-05 1975-01-16
DE2445529A1 (en) * 1974-09-24 1976-04-01 Bayer Ag Herbicidal N-(alkoxycarbonylphenyl) ureas - esp for selective control of weeds in cotton
EP0064878A1 (en) * 1981-05-08 1982-11-17 Otsuka Pharmaceutical Co., Ltd. Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same
JPS6019754A (en) * 1983-07-14 1985-01-31 Kissei Pharmaceut Co Ltd Production of aromatic carboxylic acid amide derivative
JPS60152454A (en) * 1984-01-18 1985-08-10 Terumo Corp Amide derivative and 5-lipoxigenase inhibitor containing said derivative as active component
JPS62223159A (en) * 1986-03-25 1987-10-01 Ono Pharmaceut Co Ltd (n-substituted phenyl)unsaturated acid amide derivative, production thereof and 5-lipoxygenase inhibitor containing same as active ingredient
EP0314105A2 (en) * 1987-10-29 1989-05-03 Takeda Chemical Industries, Ltd. Angiogenesis enhancer

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
C.A. Reg Nos 134046-77-8, 85126-66-5, 76888-19-2, 50466-30-3 *
C.A. Reg Nos 17090-31-2, 17090-28-7, 14056-15-6, 7600-08-0 *
CA109:142034q *
CA93:40248p *
CA94:15921r *
CA97:72722n *
CAS Online printout of 31 acylaminobenzamides *
Izv. Akad. Nauk SSSR, Ser. Khim., 1971, Vol. (10), pages 2271 to 2275 *
J. Labelled Compd. Radiopharm., 1985, Vol. 22(6), pages 623 to 630 *
Nucleic Acids Research, 1988, Vol. 16, No 23, pages 11319 to11326 *
Pharmazie, 1978, Vol. 33(10), page 688 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005546B2 (en) 1995-04-03 2006-02-28 Renovis, Inc. Acetamidobenzamide compounds for neurodegenerative disorders

Also Published As

Publication number Publication date
GB2244704A (en) 1991-12-11
GB9010129D0 (en) 1990-06-27
GB2281860A (en) 1995-03-22
GB9423929D0 (en) 1995-01-11

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20090504